Results 21 to 30 of about 26,651 (230)

Kinetic Studies of Adenine Phosphoribosyltransferase [PDF]

Journal of Biological Chemistry, 1966
Abstract The mechanism of reaction of adenine phosphoribosyl-transferase from Ehrlich ascites tumor cells was investigated kinetically by initial velocity and product inhibition studies. The data are consistent with a mechanism in which 5-phosphoribosylpyrophosphate reacts with the enzyme to form an intermediate, presumably an enzyme-ribose 5-phosphate
Makoto Hori, J. Frank Henderson
openaire   +2 more sources

NAMPT and NAPRT: Two Metabolic Enzymes With Key Roles in Inflammation

Frontiers in Oncology, 2020
Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase (NAPRT) are two intracellular enzymes that catalyze the first step in the biosynthesis of NAD from nicotinamide and nicotinic acid, respectively.
Valentina Audrito, Vincenzo Gianluca Messana, Silvia Deaglio   +2 more
doaj   +1 more source

The Role of Visfatin (Adipocytokine) Biomarker in Oral Health and Diseases among Nonobese Indian Population: A Proteomic Assay

Global Medical Genetics, 2021
Visfatin is an adipocytokine and a potential biomarker encoded by the nicotinamide phosphoribosyltransferase gene. It belongs to the nicotinic acid phosphoribosyltransferase family and involved in various metabolic processes and aging.
Amita Coutinho, Neethu Reddy, Anirban Chatterjee, Mahamad Irfanulla Khan   +3 more
doaj   +1 more source

Nicotinamide Phosphoribosyltransferase in Sepsis [PDF]

, 2012
The word sepsis was derived from the Greek word: sepsis, which means the state of putrefaction or decay. Sepsis is a potentially deadly medical condition that is characterized by a whole-body inflammatory state, called a systemic inflammatory response syndrome, and the presence of a known or suspected infection.
Dmitry N. Grigoryev, Ding You Li, Li Qin Zhang, Daniel P. Heruth, Peixin Huang, Shui Qing Ye   +5 more
openaire   +3 more sources

Biochemical characterization of uracil phosphoribosyltransferase from Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2013
Uracil phosphoribosyltransferase (UPRT) catalyzes the conversion of uracil and 5-phosphoribosyl-α-1-pyrophosphate (PRPP) to uridine 5'-monophosphate (UMP) and pyrophosphate (PP(i)). UPRT plays an important role in the pyrimidine salvage pathway since UMP
Anne Drumond Villela, Rodrigo Gay Ducati, Leonardo Astolfi Rosado, Carlos Junior Bloch, Maura Vianna Prates, Danieli Cristina Gonçalves, Carlos Henrique Inacio Ramos, Luiz Augusto Basso, Diogenes Santiago Santos   +8 more
doaj   +1 more source

Research Advances in Purine Phosphoribosyltransferases of Protozoan Parasites

Guangdong nongye kexue, 2023
Parasitic protozoa are single-celled organisms that have adapted to live in cells of humans and animals. The protozoan parasites include Leishmania spp., Trypanosoma spp., Plasmodium spp., Toxoplasma gondii, Cryptosporidium spp., and Eimeria spp., which ...
Zhihui YU, Siyun FANG, Mingfei SUN, Nanshan QI, Wenjun LIU, Juan LI, Junjing HU, Shenquan LIAO   +7 more
doaj   +1 more source

Nicotinamide Phosphoribosyltransferase Inhibitors [PDF]

, 2012
Nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate (PRPP) to yield nicotinamide mononucleotide (NMN), a rate limiting enzyme in a mammalian salvage pathway of nicotinamide adenine dinucleotide (NAD) synthesis.
Shui Qing Ye, Dan Wu, Daniel P. Heruth, Dilyara Cheranova, Li Qin Zhang   +4 more
openaire   +3 more sources

PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma

Nature Communications, 2019
Mutations in the Protein Phosphatase PPM1D are oncogenic in certain cancers including diffuse intrinsic pontine glioma (DIPG). Here, the authors show that PPM1D mutations in DIPG induce the silencing of the nicotinic acid phosphoribosyltransferase gene ...
Nathan R. Fons, Ranjini K. Sundaram, Gregory A. Breuer, Sen Peng, Ryan L. McLean, Aravind N. Kalathil, Mark S. Schmidt, Diana M. Carvalho, Alan Mackay, Chris Jones, Ángel M. Carcaboso, Javad Nazarian, Michael E. Berens, Charles Brenner, Ranjit S. Bindra   +14 more
doaj   +1 more source

Efficacy of laser capture microdissection plus RT-PCR technique in analyzing gene expression levels in human gastric cancer and colon cancer

BMC Cancer, 2008
Background Thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate phosphoribosyltransferase gene expressions are reported to be valid predictive markers for 5-fluorouracil sensitivity to gastrointestinal cancer.
Danenberg Peter V, Danenberg Kathleen, Uetake Hiroyuki, Makino Hiroshi, Sugihara Kenichi   +4 more
doaj   +1 more source

Nicotinamide Phosphoribosyltransferase in Malignancy: A Review [PDF]

Genes & Cancer, 2013
Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step of nicotinamide adenine dinucleotide (NAD) synthesis. Both intracellular and extracellular Nampt (iNampt and eNampt) levels are increased in several human malignancies and some studies demonstrate increased iNampt in more aggressive/invasive tumors and in tumor metastases ...
Emad Kandil, Kim Mayhall, Nicole M. Maxwell, Rodney E. Shackelford, Domenico Coppola   +4 more
openaire   +3 more sources