Results 21 to 30 of about 43,490 (186)
Nature Communications, 2022 NAD + metabolism is potential target to treat metabolic disorders, in part due to the effects of the NAD + dependent enzyme Sirt1. Here the authors report that hepatic nicotinamide phosphoribosyltransferase, a rate-limiting step in the NAD + salvage ...
Cassandra B. Higgins +6 more
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PRTFDC1 is a genetic modifier of HPRT-deficiency in the mouse. [PDF]
PLoS ONE, 2011 Lesch-Nyhan disease (LND) is a severe X-linked neurological disorder caused by a deficiency of hypoxanthine phosphoribosyltransferase (HPRT). In contrast, HPRT-deficiency in the mouse does not result in the profound phenotypes such as self-injurious ...
Alaine C Keebaugh +6 more
doaj +1 more source
NAMPT and NAPRT: Two Metabolic Enzymes With Key Roles in Inflammation
Frontiers in Oncology, 2020 Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase (NAPRT) are two intracellular enzymes that catalyze the first step in the biosynthesis of NAD from nicotinamide and nicotinic acid, respectively.
Valentina Audrito +2 more
doaj +1 more source
Global Medical Genetics, 2021 Visfatin is an adipocytokine and a potential biomarker encoded by the nicotinamide phosphoribosyltransferase gene. It belongs to the nicotinic acid phosphoribosyltransferase family and involved in various metabolic processes and aging.
Amita Coutinho +3 more
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PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
Nature Communications, 2019 Mutations in the Protein Phosphatase PPM1D are oncogenic in certain cancers including diffuse intrinsic pontine glioma (DIPG). Here, the authors show that PPM1D mutations in DIPG induce the silencing of the nicotinic acid phosphoribosyltransferase gene ...
Nathan R. Fons +14 more
doaj +1 more source
Research Advances in Purine Phosphoribosyltransferases of Protozoan Parasites
Guangdong nongye kexue, 2023 Parasitic protozoa are single-celled organisms that have adapted to live in cells of humans and animals. The protozoan parasites include Leishmania spp., Trypanosoma spp., Plasmodium spp., Toxoplasma gondii, Cryptosporidium spp., and Eimeria spp., which ...
Zhihui YU +7 more
doaj +1 more source
BMC Cancer, 2008 Background Thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate phosphoribosyltransferase gene expressions are reported to be valid predictive markers for 5-fluorouracil sensitivity to gastrointestinal cancer.
Danenberg Peter V +4 more
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Biochemical characterization of uracil phosphoribosyltransferase from Mycobacterium tuberculosis. [PDF]
PLoS ONE, 2013 Uracil phosphoribosyltransferase (UPRT) catalyzes the conversion of uracil and 5-phosphoribosyl-α-1-pyrophosphate (PRPP) to uridine 5'-monophosphate (UMP) and pyrophosphate (PP(i)). UPRT plays an important role in the pyrimidine salvage pathway since UMP
Anne Drumond Villela +8 more
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Nicotinamide phosphoribosyltransferase secreted from microglia via exosome during ischemic injury
Journal of Neurochemistry, 2019 Nicotinamide phosphoribosyltransferase (NAMPT) is the key enzyme of the salvage pathway of nicotinamide adenine dinucleotide synthesis. NAMPT can also be secreted and functions as a cytokine.
Yun‐Bi Lu +8 more
semanticscholar +1 more source
Pediatria i Medycyna Rodzinna, 2019 Inborn errors of metabolism that may lead to calculus formation within the urinary tract include: adenine phosphoribosyltransferase deficiency, xanthine oxidase deficiency, orotic aciduria (acidosis) type I and alkaptonuria.
Piotr Skrzypczyk +1 more
doaj +1 more source