Results 1 to 10 of about 900,190 (260)

Molecular basis for the regulation of human phosphorylase kinase by phosphorylation and Ca2+ [PDF]

Nature Communications
Phosphorylase kinase (PhK) regulates the degradation of glycogen by integrating diverse signals, providing energy to the organism. Dysfunctional mutations may directly lead to Glycogen Storage Disease type IX (GSD IX), whereas the abnormal expression of ...
Ruifang Ma, Bowen Du, Chen Shi, Lei Wang, Fuxing Zeng, Jie Han, Huiyi Guan, Yong Wang, Kaige Yan   +8 more
doaj   +3 more sources

Phosphorylase Kinase β Represents a Novel Prognostic Biomarker and Inhibits Malignant Phenotypes of Liver Cancer Cell. [PDF]

Int J Biol Sci, 2019
Glycogen phosphorylase kinase β-subunit (PHKB) is a regulatory subunit of phosphorylase kinase (PHK), involving in the activation of glycogen phosphorylase (GP) and the regulation of glycogen breakdown.
Yang W, Zhang C, Li Y, Jin A, Sun Y, Yang X, Wang B, Guo W.   +7 more
europepmc   +2 more sources

Architecture and activation of human muscle phosphorylase kinase [PDF]

Nature Communications
The study of phosphorylase kinase (PhK)-regulated glycogen metabolism has contributed to the fundamental understanding of protein phosphorylation; however, the molecular mechanism of PhK remains poorly understood. Here we present the high-resolution cryo-
Xiaoke Yang, Mingqi Zhu, Xue Lu, Yuxin Wang, Junyu Xiao   +4 more
doaj   +2 more sources

Phosphorylase Kinase Inhibition Therapy in Burns and Scalds [PDF]

BioDiscovery, 2017
Severe burns and scalds almost always result in unsightly hypertrophic scarring. Among the important processes involved in scarring are fibroblast formation and transformation of fibroblasts into myofibroblasts.
Madalene Heng
doaj   +4 more sources

A novel sequence of the PHKG 2 mutation associated with the first case of glycogen storage diseases type IXc in Syria: a case report and review of literature [PDF]

Journal of Medical Case Reports
Background Glycogen storage diseases are a group of inherited metabolic disorders that affect the body’s ability to break down and/or store glycogen. Type IX glycogen storage disease is an inherited disorder caused by a deficiency of phosphorylase kinase,
Seba Harh, Shaza Shahoud, Shady Daher, Diana Alasmar   +3 more
doaj   +2 more sources

Glycogen storage disorder types IX: the mutation spectrum and ethnic distribution [PDF]

Orphanet Journal of Rare Diseases
Glycogen storage disorders (GSD) GSD-IX are characterized by deficiencies in muscular and/or hepatic phosphorylase enzymes. GSD type IX za is an X-linked disorder, while IXb and IXc are autosomal recessive disorders resulting from pathogenic variants in ...
Bita Geramizadeh, Fatih Ezgu, Zahra Beyzaei   +2 more
doaj   +2 more sources

Glycogen-storage disease in rats, a genetically determined deficiency of liver phosphorylase kinase [PDF]

Biochemical Journal, 1980
R. Malthus, D. Clark, C. Watts, J. Sneyd
openalex   +2 more sources

The regulatory α and β subunits of phosphorylase kinase directly interact with its substrate, glycogen phosphorylase. [PDF]

Biochem Biophys Res Commun, 2017
Thompson JA, Carlson GM.
europepmc   +3 more sources

Phosphorylation and inactivation of glycogen synthase by phosphorylase kinase.

Proceedings of the National Academy of Sciences of the United States of America, 1979
Thomas R. Soderling, Ashok K. Srivastava, Martha A. Bass, Balwant S. Khatra   +3 more
openalex   +2 more sources

Fatal Congenital Heart Glycogenosis Caused by a Recurrent Activating R531Q Mutation in the γ2-Subunit of AMP-Activated Protein Kinase (PRKAG2), Not by Phosphorylase Kinase Deficiency [PDF]

American Journal of Human Genetics, 2005
Barbara Burwinkel, John W. Scott, Christoph Bührer, Frank K.H. van Landeghem, Gerald F. Cox, Callum Wilson, D. Grahame Hardie, Manfred W. Kilimann   +7 more
openalex   +2 more sources