Results 171 to 180 of about 28,187 (220)
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Phosphorylase kinase isozymes and phosphorylase in denervated skeletal muscles
Muscle & Nerve, 1990AbstractThe effects of motor denervation on levels of phosphorylase kinase isozymes and phosphorylase were investigated in rat epitrochlearis, hemidiaphragm, and soleus muscles. Amounts of the proteins were measured after quantitative immunoprecipitation and found to be decreased by as much as 70% 2 weeks after denervation.
J C, Lawrence, R L, Smith
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Interaction of phosphorylase kinase with polymyxins
Biochemical and Biophysical Research Communications, 1985Nonactivated rabbit skeletal muscle phosphorylase kinase is inhibited by the polymyxins A, B, D and E when assayed at pH 8.6. Polymyxin B is the most effective inhibitor, causing 50% inhibition at 0.3 mM. Following the effect of polymyxin B on the kinase activity toward troponin, no inhibition was observed. In contrast, polymyxin B was found to greatly
Ktenas, T. B. +3 more
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Evidence that phosphorylase kinase exhibits phosphatidylinositol kinase activity
Biochemistry, 1986Phosphorylase kinase phosphorylates the pure phospholipid phosphatidylinositol. Furthermore, it catalyzed phosphatidylinositol 4-phosphate formation using as substrate phosphatidylinositol that is associated with an isolated trypsin-treated Ca2+-transport adenosinetriphosphatase (ATPase) preparation from skeletal muscle sarcoplasmic reticulum.
Z, Georgoussi, L M, Heilmeyer
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Biochemistry, 1982
Phosphorylase kinase exhibits three kinds of enzymatic activities. A partial activity, A0, catalyzes the phosphorylation of phosphorylase b, troponin I, and phosphorylase kinase itself (autophosphorylation); A1 can utilize only phosphorylase b and phosphorylase kinase as the substrate, whereas A2 can utilize only phosphorylase b and troponin T ...
M W, Kilimann, L M, Heilmeyer
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Phosphorylase kinase exhibits three kinds of enzymatic activities. A partial activity, A0, catalyzes the phosphorylation of phosphorylase b, troponin I, and phosphorylase kinase itself (autophosphorylation); A1 can utilize only phosphorylase b and phosphorylase kinase as the substrate, whereas A2 can utilize only phosphorylase b and troponin T ...
M W, Kilimann, L M, Heilmeyer
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Adult phosphorylase b kinase deficiency
Annals of Neurology, 1990AbstractPhosphorylase b kinase deficiency affecting muscle has been observed infrequently in children with weakness and hepatomegaly, and in 2 adults with cramps on exertion. We observed 2 additional adults with phosphorylase b kinase deficiency: Patient 1, aged 58, had progressive, predominantly distal weakness since age 46 but no cramps on exertion ...
P R, Clemens, M, Yamamoto, A G, Engel
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An automated assay for phosphorylase kinase
Analytical Biochemistry, 1974Abstract A fully automated assay of phosphorylase kinase capable of processing 40 samples/hr is described. Problems due to enzyme adsorbed to the incubation coil and thereby producing a continuous rise of the base line were overcome by washing with a solution containing 0.05% Triton X-100, 0.03% SDS, and 5 m m EDTA.
H P, Jennissen, L M, Heilmeyer
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Muscle phosphorylase b kinase deficiency revisited
Neuromuscular Disorders, 2010Muscle phosphorylase b kinase (PHK) deficiency (glycogenosis type VIII) is a rare disorder caused by mutations in the PHKA1 gene encoding the alpha(M) subunit of PHK. Only 5 patients with molecular defects in the X-linked PHKA1 gene have been described until now, and they all presented with exercise intolerance.
Andoni, Echaniz-Laguna +6 more
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Adult muscle phosphorylase "b" kinase deficiency
Neurology, 1986A 35-year-old man had severe exercise intolerance and cramps. Venous blood lactate did not rise after ischemic exercise, and electromyographically silent contracture of hand muscles appeared. Histochemistry and electronmicroscopy of a muscle biopsy revealed subsarcolemmal and intermyofibrillar accumulation of glycogen.
J M, Abarbanel +5 more
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European Journal of Pediatrics, 1985
Lymphocyte phosphorylase kinase activities were measured in normal controls and in patients with the sex-linked form of liver phosphorylase kinase deficiency. The reaction due to phosphorylase kinase activity in normal lymphocytes (2.7 X 10(6) in the reaction tube) was found to be linear within 20-60 min at 30 degrees C.
K, Goji +4 more
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Lymphocyte phosphorylase kinase activities were measured in normal controls and in patients with the sex-linked form of liver phosphorylase kinase deficiency. The reaction due to phosphorylase kinase activity in normal lymphocytes (2.7 X 10(6) in the reaction tube) was found to be linear within 20-60 min at 30 degrees C.
K, Goji +4 more
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1986
Publisher Summary Protein phosphorylation and dephosphorylation are well recognized as major metabolic control mechanisms in eukaryotic cells. By the 1940s, through work in the laboratories of Con and others, the basic biochemistry of glycogen breakdown had been established with the characterization of the phosphorylase-catalyzed conversion of ...
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Publisher Summary Protein phosphorylation and dephosphorylation are well recognized as major metabolic control mechanisms in eukaryotic cells. By the 1940s, through work in the laboratories of Con and others, the basic biochemistry of glycogen breakdown had been established with the characterization of the phosphorylase-catalyzed conversion of ...
openaire +1 more source