Results 211 to 220 of about 2,046,842 (395)

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Phosphorylation of slit diaphragm proteins NEPHRIN and NEPH1 upon binding of HGF promotes podocyte repair

, 2021
Ashish K. Solanki, Ehtesham Arif, Pankaj Srivastava, Christopher M. Furcht, Bushra Rahman, Pei Wen, Avinash Singh, Lawrence B. Holzman, Wayne R. Fitzgibbon, Milos N. Budisavljevic, Glenn P. Lobo, Sang‐Ho Kwon, Zhe Han, Matthew J. Lazzara, Joshua H. Lipschutz, Deepak Nihalani   +15 more
openalex   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

The absence of endogenous β-endorphin selectively blocks phosphorylation and desensitization of mu opioid receptors following partial sciatic nerve ligation

, 2007
M. Petraschka, Shuang Li, Terri L. Gilbert, R. Westenbroek, Michael R. Bruchas, Shaul Schreiber, John Lowe, Malcolm J. Low, John E. Pintar, Charles Chavkin   +9 more
openalex   +1 more source

Hypoxia increases persulfide and polysulfide formation by AMP kinase dependent cystathionine gamma lyase phosphorylation

, 2023
Shafiul Alam, Sibile Pardue, Xinggui Shen, John Glawe, Takashi Yagi, Mohammad Alfrad Nobel Bhuiyan, Rakesh P. Patel, Paari Dominic, Chiranjiv Virk, Md. Shenuarin Bhuiyan, A. Wayne Orr, Chad M. Petit, Gopi K. Kolluru, Christopher G. Kevil   +13 more
openalex   +1 more source

Imatinib blocks tyrosine phosphorylation of Smad4 and restores TGF-β growth-suppressive signaling in BCR-ABL1-positive leukemia [PDF]

, 2023
Lijing Wang, Shuchen Gu, Fenfang Chen, Yi Yu, Jin Cao, Xinran Li, Chun Gao, Yanzhen Chen, Shuchong Yuan, Xia Liu, Jun Qin, Bin Zhao, Pinglong Xu, Tingbo Liang, Hongyan Tong, Xia Lin, Xin‐Hua Feng   +16 more
openalex   +1 more source

phosphorylation

, 2014
Citation: 'phosphorylation' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.PT06790 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Effect of downregulated citrate synthase on oxidative phosphorylation signaling pathway in HEI-OC1 cells [PDF]

, 2022
Xiaowen Xu, Yue Liu, Jun Luan, Rongrong Liu, Yan Wang, Yingying Liu, Ang Xu, Bingxin Zhou, Fengchan Han, Wenjing Shang   +9 more
openalex   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source