Results 211 to 220 of about 1,642,696 (345)

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

An integrative molecular systems approach unravels mechanisms underlying biphasic nitrate uptake by plant nitrate transporter NRT1.1. [PDF]

NPJ Syst Biol Appl
Subhadarshini S, Sahoo S, Jolly MK, Rashid M.   +3 more
europepmc   +1 more source

Oxidative phosphorylation in insect sarcosomes [PDF]

, 1954
S. E. Lewis, E.C. Slater
openalex   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Pioneering discovery: US3-phosphorylated sites on VP22 orchestrate duck plague virus release and pathogenicity. [PDF]

Poult Sci
Wu L, Cheng A, Wang M, Yang Q, Ou X, Sun D, He Y, Wu Z, Tian B, Huang J, Wu Y, Zhang S, Zhao X, Yu Y, Zhang L, Zhu D, Liu M, Jia R, Chen S.   +18 more
europepmc   +1 more source

ANAEROBIC PHOSPHORYLATION DUE TO THE DISMUTATION OF α-KETOGLUTARIC ACID IN THE PRESENCE OF AMMONIA

, 1949
F. Edmund Hunter, Walter S. Hixon
openalex   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Phosphorylation as a candidate regulatory mechanism for effector recruitment to tankyrase. [PDF]

R Soc Open Sci
Broadway BJ, Pollock K, Cronin N, Rottapel R, Sicheri F, Guettler S.   +5 more
europepmc   +1 more source

Phosphorylation coupled with the oxidation of α-ketoglutarate by heart-muscle sarcosomes. 3. Experiments with ferricytochrome c as hydrogen acceptor [PDF]

, 1955
E.C. Slater
openalex   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source