Results 261 to 270 of about 2,046,842 (395)

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

FeaSion decodes the regulatory landscape and functional diversity of RNA polymerase II CTD phosphorylation. [PDF]

Sci Adv
Zhu J, Bao L, Xu S, Ji X.
europepmc   +1 more source

Bidirectional regulation of fragile X mental retardation protein phosphorylation controls rhodopsin homoeostasis [PDF]

, 2016
Xiao Wang, Yawen Mu, Mengshi Sun, Junhai Han   +3 more
openalex   +1 more source

Lung Microphysiological System Validates Novel Cell Therapy for Acute Respiratory Distress Syndrome

Advanced Biology, EarlyView.
This study aims to evaluate the efficacy of primed mesenchymal stem cells (pMSCs) as an alternative treatment for Acute Respiratory Distress Syndrome (ARDS), based on a novel lung microphysiological system (MPS) to test the efficacy of pMSCs over the standard treatment, Dexamethasone.
Bokyong Kim, So‐Hui Kim, Jieun Kim, Eun‐Young Eo, Hyung‐Jun Kim, Jae Ho Lee, Choon‐Taek Lee, Taeho Kong, Su Kyoung Seo, Seunghee Lee, Jeongbin Park, Young‐Jae Cho   +11 more
wiley   +1 more source

Integrative Multi-Omics Analyses Reveal the Global Regulation Network of the Microalga <i>Nannochloropsis oceanica</i> Under Nitrogen Stress Adaptation. [PDF]

Biology (Basel)
You W, Xu C, Zhang J, Poetsch A.
europepmc   +1 more source

Cdk phosphorylation licenses Kif4A chromosome localization required for early mitotic progression [PDF]

, 2018
Zhixiong Dong, Changjun Zhu, Qimin Zhan, Wei Jiang   +3 more
openalex   +1 more source

Loss of Stat3 in Prx1+ Progenitors Impairs Molar Root Development

Advanced Biology, EarlyView.
Stat3 critically regulates mandibular first molar and alveolar bone morphogenesis. Conditional ablation of Stat3 disrupts the osteogenic capacity of Prx1+ mesenchymal progenitors, as evidenced across in vivo and in vitro models. Abstract Signal Transducer and Activator of Transcription 3 (Stat3) acts as a central transcriptional modulator coordinating ...
Xin Feng, Wangyu Luo, Yichen Yao, Lichieh Lin, Laiting Chan, Jiarui Lu, Zijing Huang, Jingyi Feng, Le Zhao, Xiaolei Zhang, Liu Yang   +10 more
wiley   +1 more source

Regulation of cellular states via targeted phosphorylation of p53 using a nanobody-coupled kinase system. [PDF]

Cell Death Discov
Lim HE, Yoo HY.
europepmc   +1 more source

Phosphorylation of the alpha-I motif in SYMRK drives root nodule organogenesis [PDF]

Nikolaj B. Abel, Malita Malou Malekzadeh Nørgaard, Simon B. Hansen, Kira Gysel, Ignacio Arribas Díez, Ole N. Jensen, Jens Stougaard, Kasper R. Andersen   +7 more
openalex   +1 more source

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

Proceedings of the National Academy of Sciences of the United States of America, 2007
S. Jäger, Christoph Handschin, J. St-Pierre, B. Spiegelman   +3 more
semanticscholar   +1 more source