Results 261 to 270 of about 1,612,762 (345)

A Novel Brain Penetrable Nanocarrier Delivers Brain‐Derived Neurotrophic Factor to Treat Alzheimer's Disease

Advanced Healthcare Materials, EarlyView.
A novel blood‐brain barrier‐penetrating terpolymer nanoparticle to deliver brain‐derived neurotrophic factor (BDNF) for the treatment of Alzheimer's disease (AD) is designed. The BDNF‐TPN significantly enhances BDNF accumulation in the brain following intravenous injection, reduces apoptosis and neuroinflammation, thus promoting neuronal survival and ...
Lily Yi Li, Elliya Park, Chunsheng He, Azhar Z. Abbasi, Pei Zhi, Paul E. Fraser, Andrew M. Rauth, Jeffery T. Henderson, Xiao Yu Wu   +8 more
wiley   +1 more source

ANAEROBIC PHOSPHORYLATION DUE TO THE DISMUTATION OF α-KETOGLUTARIC ACID IN THE PRESENCE OF AMMONIA

, 1949
F. Edmund Hunter, Walter S. Hixon
openalex   +1 more source

The multifaceted impact of physical exercise on FoxO signaling pathways. [PDF]

Front Cell Dev Biol
Liu W, Meng P, Li Z, Shen Y, Meng X, Jin S, Hu M.   +6 more
europepmc   +1 more source

Impact of Nanoparticle Stiffness on Endosomal Escape and Signaling Pathways in Cytosolic Delivery

Advanced Healthcare Materials, EarlyView.
Nanoparticle (NP) stiffness affects cellular uptake, but its impact on intracellular distribution remains unclear. This study synthesizes silica nanocapsules with varying stiffness, inspired by viral mechanisms, and applies assays to measure cellular uptake and escape efficiency.
Yali Zhang, Yue Hui, Zichao Guo, Dawei Liu, Yun Liu, Huajian Gao, Chun‐Xia Zhao   +6 more
wiley   +1 more source

Targeting negative phosphorylation to activate AMPK. [PDF]

Endocr Connect
Pearah A, Ramatchandirin B, Ramirez K, Radovick S, Wondisford FE, He L.   +5 more
europepmc   +1 more source

Therapeutic Implants: Mechanobiologic Enhancement of Osteogenic, Angiogenic, and Myogenic Responses in Human Mesenchymal Stem Cells on 3D‐Printed Titanium Truss

Advanced Healthcare Materials, EarlyView.
This study investigates a synergistic effect between 3D‐printed surface features and mechanical micro‐strain in enhancing the osteogenic, angiogenic, and myogenic responses of human mesenchymal stem cells (hMSCs). Load‐induced mechanotransduction, facilitated by the implant's architectural design, significantly amplifies hMSC differentiation.
Se‐Hwan Lee, Ali Kiapour, Brendan D. Stoeckl, Ellen Y. Zhang, Matthew R. Begley, Jarod Oldham, Lewis Harrison, Jessee Hunt, Robert L. Mauck, Su Chin Heo   +9 more
wiley   +1 more source

BRG1 inhibits glycolysis by promoting SHP1-mediated dephosphorylation of PKM2 in non-small cell lung cancer. [PDF]

Oncogenesis
Zhan W, Zhang H, She X, Zhang G, Zhang J, Luo X, Li H, Lan J.   +7 more
europepmc   +1 more source

Protein phosphorylation in apoptosis

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1995
Bjørn Tore Gjertsen, Stein Ove Døskeland   +1 more
openaire   +3 more sources

Induction of Nephron–Ductal Dual Lineages via Early Retinoic Acid Signaling Establishes a Platform for Fully Patterned Kidney Organoids

Advanced Healthcare Materials, EarlyView.
A simplified, co‐culture‐free protocol for kidney organoids that generate segmented nephrons, including collecting ducts, has been developed. Early low‐dose RA with FGF9 induces balanced anterior–posterior IM patterning and dual UE/MM lineage commitment. BMP7 enhances nephron progenitor maturation.
Jung Hwa Lim, Seeun Kim, Dong Hyun Lee, Dae Hun Kim, Hye Bin Lee, Ye Seul Son, Mi‐Young Son, Soo Jin Oh, Ji‐Yoon Lee, Mi‐Ok Lee, Hyun Soo Cho, Dae‐Soo Kim, Cho‐Rok Jung, Hyun Mi Kang   +13 more
wiley   +1 more source