Results 291 to 300 of about 2,046,842 (395)

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

A Duality of Function: An Integrative Model of RACK1 as a Switch Between Translational and Signaling Hubs. [PDF]

Int J Mol Sci
Kolosov P, Biziaev N, Alkalaeva E.
europepmc   +1 more source

Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

Science Signaling, 2010
J. V. Olsen, M. Vermeulen, A. Santamaría, Chanchal Kumar, Martin L. Miller, L. Jensen, Florian Gnad, J. Cox, T. S. Jensen, E. Nigg, S. Brunak, M. Mann   +11 more
semanticscholar   +1 more source

Gold Nanoclusters as Dual Agents for Engineering Tumor Vascular Leakiness and Performing Photothermal Therapy

Advanced Functional Materials, EarlyView.
Many cancer nanotherapeutics, while potent, suffer from the inability to escape from the tumor vasculature, especially in the absence of endothelial permeability. In this work, ultrasmall gold nanoclusters could engineer nanomaterials induced endothelial leakiness (NanoEL) and harness strong NIR induced photothermal characteristics to suppress tumor ...
Nengyi Ni, Kuoran Xing, Bihan Zhang, Baoteng Wang, Yinglu Chen, Jianping Xie, Xiao Sun, Jinping Wang, David Tai Leong   +8 more
wiley   +1 more source

mGluR5/ERK signaling regulated the phosphorylation and function of glycine receptor α1ins subunit in spinal dorsal horn of mice

, 2019
Ziyang Zhang, Hu-Hu Bai, Zhen Guo, Huling Li, Yongtao He, Xing-Lian Duan, Zhan‐Wei Suo, Xian Yang, Yong‐Xing He, Xiao‐Dong Hu   +9 more
openalex   +2 more sources

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

Science, 2011
P. Wild, H. Farhan, David G. McEwan, Sebastian A. Wagner, V. Rogov, N. Brady, Benjamin Richter, Jelena Korać, O. Waidmann, Chunaram Choudhary, V. Dötsch, D. Bumann, I. Dikič   +12 more
semanticscholar   +1 more source

Cell Surface Thiol Engineering Mechanoregulates Myogenic Differentiation via the FAK–PI3K–AKT Axis

Advanced Healthcare Materials, EarlyView.
Schematic diagram illustrating how cell surface modification of skeletal muscle progenitor cells through TCEP treatment reveals enhanced cell adhesion, intracellular tension, and myogenesis at 19.66 kPa stiffness, leading to optimal cell fusion. In contrast, no significant changes are observed in the softer (10.61 kPa) or stiffer (49.4 kPa) matrices ...
Juyeon Kim, Sung Sik Hur, Jae Hong Park, Myung Jin Ban, Jin‐Young Kim, Joo Hyun Kim, Ji Hyae Choo, Hae‐Won Kim, Ju Hun Lee, Man Ryul Lee, Yongsung Hwang   +10 more
wiley   +1 more source

Impact of C-Terminal PKC Phosphorylation on TRPC6 Current Kinetics. [PDF]

Int J Mol Sci
Keck M, Pöll S, Schmelzer H, Kressmann T, Hermann C, Mederos Y Schnitzler M, Storch U.   +6 more
europepmc   +1 more source

A Novel Brain Penetrable Nanocarrier Delivers Brain‐Derived Neurotrophic Factor to Treat Alzheimer's Disease

Advanced Healthcare Materials, EarlyView.
A novel blood‐brain barrier‐penetrating terpolymer nanoparticle to deliver brain‐derived neurotrophic factor (BDNF) for the treatment of Alzheimer's disease (AD) is designed. The BDNF‐TPN significantly enhances BDNF accumulation in the brain following intravenous injection, reduces apoptosis and neuroinflammation, thus promoting neuronal survival and ...
Lily Yi Li, Elliya Park, Chunsheng He, Azhar Z. Abbasi, Pei Zhi, Paul E. Fraser, Andrew M. Rauth, Jeffery T. Henderson, Xiao Yu Wu   +8 more
wiley   +1 more source

Post-Translational Modifications of Huntingtin: Mechanistic Insights and Therapeutic Opportunities in Huntington's Disease. [PDF]

Int J Mol Sci
Zhang X, Zhang S, Wang C.
europepmc   +1 more source