Results 111 to 120 of about 2,980 (135)
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Selective loss of phosphoserine aminotransferase 1 (PSAT1) suppresses migration, invasion, and experimental metastasis in triple negative breast cancer

Clinical & Experimental Metastasis, 2019
Breast cancer is the second leading cause of cancer-related deaths among women and 90% of these mortalities can be attributed to progression to metastatic disease. In particular, triple negative breast cancer (TNBC) is extremely aggressive and frequently metastasizes to multiple organs. As TNBCs are categorized by their lack of hormone receptors, these
Stephanie Metcalf   +6 more
openaire   +2 more sources

Untersuchungen zum Serin- und Glycin-Metabolismus und der Phosphoserin-Aminotransferase 1 in der Modellzelllinie P493-6

2023
Ein wesentliches Merkmal von Tumorzellen stellt die Reprogrammierung des Zellmetabolismus dar. Auch die komplexe Genese aggressiver Non-Hodgkin-Lymphome wie dem diffus großzelligen B-Zell-Lymphom (DLBCL) geht mit einem Umbau des zellulären Stoffwechsels einher.
Harms, Wilken   +5 more
openaire   +2 more sources

Potential Role For A Phosphoserine Aminotransferase 1 And Pyruvate Kinase M2 (PSAT1:PKM2) Functional Interaction In Lung Cancer Cells

The FASEB Journal, 2017
Cellular production of serine provides precursors for numerous anabolic reactions, particularly for proteins and nucleic acid synthesis and for one carbon metabolism, and this pathway has been demonstrated to be elevated in many different cancer types.
Brian F Clem   +5 more
openaire   +1 more source

Knockdown of ERN1 disturbs the expression of phosphoserine aminotransferase 1 and related genes in glioblastoma cells

Archives of Biochemistry and Biophysics
Endoplasmic reticulum stress and synthesis of serine are essential for tumor growth, but the mechanism of their interaction is not clarified yet. The overarching goal of this work was to investigate the impact of ERN1 (endoplasmic reticulum to nucleus signaling 1) inhibition on the expression of serine synthesis genes in U87MG glioblastoma cells ...
Oleksandr H. Minchenko   +6 more
openaire   +2 more sources

Abstract 3563: Potential role for a phosphoserine aminotransferase 1 and pyruvate kinase M2 (PSAT1:PKM2) functional interaction in lung cancer cells

Cancer Research, 2017
Abstract Cellular production of serine provides precursors for numerous anabolic reactions, particularly for proteins and nucleic acid synthesis and for one carbon metabolism, and this pathway has been demonstrated to be elevated in many different cancer types.
Rumeysa B. Sit   +5 more
openaire   +1 more source

Phosphoserine Aminotransferase has Conserved Active Site from Microbes to Higher Eukaryotes with Minor Deviations

Protein and Peptide Letters, 2021
Rohit Kumar Singh   +2 more
exaly  

Phosphoserine Aminotransferase Pathogenetic Variants in Serine Deficiency Disorders: A Functional Characterization

Biomolecules, 2023
Annalisa Bianchera   +2 more
exaly  

Molecular Structure of Phosphoserine Aminotransferase from Saccharomyces cerevisiae

International Journal of Molecular Sciences, 2023
Jeong Ho Chang
exaly  

Structural basis ofL-phosphoserine binding toBacillus alcalophilusphosphoserine aminotransferase

Acta Crystallographica Section D: Biological Crystallography, 2013
Anastassios C Papageorgiou   +1 more
exaly  

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