Results 21 to 30 of about 5,158 (158)

Hepatic Phosphoserine Aminotransferase 1 Regulates Insulin Sensitivity in Mice via Tribbles Homolog 3 [PDF]

Diabetes, 2014
Phosphoserine aminotransferase 1 (PSAT1) is an enzyme participating in serine synthesis. A role of PSAT1 in the regulation of insulin sensitivity, however, is unknown. In this study, we showed that hepatic PSAT1 expression and liver serine levels are reduced in genetically engineered leptin receptor–deficient (db/db) mice and high-fat diet (HFD ...
Junjie, Yu, Fei, Xiao, Yajie, Guo, Jiali, Deng, Bin, Liu, Qian, Zhang, Kai, Li, Chunxia, Wang, Shanghai, Chen, Feifan, Guo   +9 more
openaire   +2 more sources

AMPK-HIF-1α signaling enhances glucose-derived de novo serine biosynthesis to promote glioblastoma growth

Journal of Experimental & Clinical Cancer Research, 2023
Background Cancer cells undergo cellular adaptation through metabolic reprogramming to sustain survival and rapid growth under various stress conditions. However, how brain tumors modulate their metabolic flexibility in the naturally serine/glycine (S/G)-
Hye Jin Yun, Min Li, Dong Guo, So Mi Jeon, Su Hwan Park, Je Sun Lim, Su Bin Lee, Rui Liu, Linyong Du, Seok-Ho Kim, Tae Hwan Shin, Seong-il Eyun, Yun-Yong Park, Zhimin Lu, Jong-Ho Lee   +14 more
doaj   +1 more source

RNA-Seq of Phenotypically Distinct Eimeria maxima Strains Reveals Coordinated and Contrasting Maturation and Shared Sporogonic Biomarkers with Eimeria acervulina

Pathogens, 2023
Strains of Eimeria maxima, an enteric parasite of poultry, vary in virulence. Here, we performed microscopy and RNA sequencing on oocysts of strains APU-1 (which exhibits more virulence) and APU-2.
Matthew S. Tucker, Celia N. O’Brien, Alexis N. Johnson, Jitender P. Dubey, Benjamin M. Rosenthal, Mark C. Jenkins   +5 more
doaj   +1 more source

Post-translational regulation of human D-3-phosphoglycerate dehydrogenase in Alzheimer's disease. [PDF]

Protein Sci
Abstract Emerging evidence suggests that sex‐specific differences in L‐serine (L‐Ser) metabolism play a key role in Alzheimer's disease (AD). While disruptions in amino acid balance are well known, recent findings point to a dimorphic regulation of the serine biosynthetic pathway.
Zerbini E, Riva D, Maffioli E, Tedeschi G, Sacchi S, Pollegioni L.   +5 more
europepmc   +2 more sources

Genes for asparagine metabolism in Lotus japonicus : differential expression and interconnection with photorespiration [PDF]

, 2017
Background: Asparagine is a very important nitrogen transport and storage compound in plants due to its high nitrogen/carbon ratio and stability.
Betti, Marco, Credali, Alfredo, García Calderón, Margarita, Márquez Cabeza, Antonio José, Pérez Delgado de Torres, Carmen María, Vega Piqueres, José María   +5 more
core   +1 more source

Phosphoglycerate Dehydrogenase: Potential Therapeutic Target and Putative Metabolic Oncogene [PDF]

, 2014
Exemplified by cancer cells' preference for glycolysis, for example, the Warburg effect, altered metabolism in tumorigenesis has emerged as an important aspect of cancer in the past 10–20 years.
Zogg, Cheryl K.
core   +3 more sources

SARS-CoV-2 and Glutamine: SARS-CoV-2 Triggered Pathogenesis via Metabolic Reprograming of Glutamine in Host Cells

Frontiers in Molecular Biosciences, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, as coronavirus disease 2019 (COVID-19) pandemic, has killed more than a million people worldwide, and researchers are constantly working to develop therapeutics in the treatment and ...
Shiv Bharadwaj, Mahendra Singh, Nikhil Kirtipal, Sang Gu Kang   +3 more
doaj   +1 more source

In Vivo Biosynthesis and Direct Incorporation of Noncanonical Amino Acids into Proteins. [PDF]

Chembiochem
This review evaluates engineered (semi)autonomous cell systems for the biosynthesis and incorporation of noncanonical amino acids (ncAAs) into proteins. While semi‐autonomous cells convert supplied precursors into ncAAs autonomous cells integrate biosynthetic pathways that produce these building blocks intracellularly.
Illies JH, Weber TM, Drienovská I.
europepmc   +2 more sources

An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation [PDF]

, 2015
Background The gene encoding the serine biosynthesis pathway enzyme PHGDH is located in a region of focal genomic copy number gain in human cancers. Cells with PHGDH amplification are dependent on enzyme expression for proliferation. However, dependence
Brignole, Edward J, Davidson, Shawn Michael, Drennan, Catherine L, Fiske, Brian Prescott, Kini, Mitali, Mattaini, Katherine Ruth, Vander Heiden, Matthew G.   +6 more
core   +1 more source

Human Cerebral Cortex Proteome of Fragile X-Associated Tremor/Ataxia Syndrome

Frontiers in Molecular Biosciences, 2021
Background: Fragile X-associated tremor/ataxia syndrome (FXTAS) is an adult-onset neurodegenerative disorder associated with premutation CGG-repeat expansions (55–200 repeats) in the 5′ non-coding portion of the fragile X mental retardation 1 (FMR1) gene.
Katharine Nichole Holm, Anthony W. Herren, Sandra L. Taylor, Jamie L. Randol, Kyoungmi Kim, Kyoungmi Kim, Glenda Espinal, Verónica Martínez-Cerdeño, Verónica Martínez-Cerdeño, Isaac N. Pessah, Isaac N. Pessah, Randi J. Hagerman, Randi J. Hagerman, Paul J. Hagerman, Paul J. Hagerman   +14 more
doaj   +1 more source