Frontiers in Molecular Biosciences, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, as coronavirus disease 2019 (COVID-19) pandemic, has killed more than a million people worldwide, and researchers are constantly working to develop therapeutics in the treatment and ...
Shiv Bharadwaj +3 more
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Phosphoserine aminotransferase deficiency: a novel disorder of the serine biosynthesis pathway. [PDF]
, 2007 We present the first two identified cases of phosphoserine aminotransferase deficiency. This disorder of serine biosynthesis has been identified in two siblings who showed low concentrations of serine and glycine in plasma and cerebrospinal fluid ...
Achouri, Younes +13 more
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Human Cerebral Cortex Proteome of Fragile X-Associated Tremor/Ataxia Syndrome
Frontiers in Molecular Biosciences, 2021 Background: Fragile X-associated tremor/ataxia syndrome (FXTAS) is an adult-onset neurodegenerative disorder associated with premutation CGG-repeat expansions (55–200 repeats) in the 5′ non-coding portion of the fragile X mental retardation 1 (FMR1) gene.
Katharine Nichole Holm +14 more
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Cooperativity of Glucocorticoid Response Elements Located Far Upstream of the Tyrosine Aminotransferase Gene [PDF]
, 1987 Two glucocorticoid response elements (GREs) located 2.5 kb upstream of the transcription initiation site of the tyrosine aminotransferase gene were identified by gene transfer experiments and shown to bind to purified glucocorticoid receptor.
Strähle, Uwe +7 more
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Altered expression of genes involved in the serine synthesis pathway (SSP) in patients with acute myeloid leukemia [PDF]
Journal of Kerman University of Medical SciencesBackground: Acute myeloid leukemia (AML) is characterized by the uncontrolled proliferation of malignant cells, which rely on various metabolic pathways to sustain their survival and growth.
Parinaz Khadem +4 more
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Expressions and roles of key enzymes in serine synthesis pathway in NaAsO2-treated HaCaT cells
环境与职业医学, 2022 BackgroundThe key enzymes of serine synthesis pathway (SSP) play an important role in tumor growth, proliferation, and invasion, but their roles in arsenic carcinogenesis are unclear.ObjectiveTo observe the effects of NaAsO2 treatment on the expressions ...
Fengmin LI +5 more
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Transcriptome analysis of primary human oral keratinocytes stimulated with Prevotella melaninogenica
口腔疾病防治, 2022 Objective To investigate the transcriptomic changes in primary human oral keratinocytes (pHOKs) after coculture with Prevotella melaninogenica (P.m) and to verify the changes in human oral keratinocyte (HOK) cell lines.
GUO Yiting +4 more
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Scientific Reports, 2020 Phosphoenolpyruvate carboxykinase (PEPCK) is a gluconeogenic enzyme with a cytosolic (Pck1/PEPCK-C) and mitochondrial (Pck2/PEPCK-M) isoform. Here we investigate the effect of 3-mercaptopicolinic acid (3-MPA), a PEPCK inhibitor, on C2C12 muscle cells. We
Madelaine C. Brearley +4 more
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Targeting PSAT1 to mitigate metastasis in tumors with p53-72Pro variant
Signal Transduction and Targeted Therapy, 2023 The single-nucleotide polymorphism (SNP) of p53, in particular the codon 72 variants, has recently been implicated as a critical regulator in tumor progression. However, the underlying mechanism remains elusive.
Jingwen Jiang +14 more
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An integrated pan-cancer analysis of PSAT1: A potential biomarker for survival and immunotherapy
Frontiers in Genetics, 2022 Phosphoserine aminotransferase 1 (PSAT1) may be an oncogene that plays an important role in various cancer types. However, there are still many gaps in the expression of PSAT1 gene and its biological impact in different types of tumors.
Mingtao Feng +10 more
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