Results 21 to 30 of about 29,721,904 (163)

Phosphoserine aminotransferase 1 promotes serine synthesis pathway and cardiac repair after myocardial infarction. [PDF]

Theranostics
Background and Purpose: The permanent loss of cardiomyocytes (CMs) following myocardial infarction (MI), coupled with the heart's limited regenerative capacity, often leads to heart failure. Phosphoserine aminotransferase 1 (PSAT1) is a protein highly expressed in the embryonic mouse heart but markedly downregulated after birth. Despite its presence in
Magadum A, Mallaredy V, Roy R, Joladarashi D, Thej C, Cheng Z, Cimini M, Truongcao M, Chatoff A, Crispim CV, Rigaud VOC, Gonzalez C, Benedict C, Santos CXC, Snyder NW, Khan M, Shah AM, Koch WJ, Kishore R.   +18 more
europepmc   +3 more sources

Cancer-associated Fibroblast-like Cells Promote Osteosarcoma Metastasis by Upregulation of Phosphoserine Aminotransferase 1 and Activation of the mTOR/S6K Pathway. [PDF]

Int J Biol Sci
Metastasis remains a major obstacle limiting the survival of patients with osteosarcoma (OS). Cross-talk between cancer-associated fibroblasts (CAFs) and OS cells has been found to facilitate metastasis, although the effects of CAFs on OS cell metabolism are poorly understood.
Feng L, Xiao G, Chen Y, Ye T, Fan L, Xie Y, Mei T, Wang L, Ge J, Ye C, Chen J.   +10 more
europepmc   +3 more sources

L-serine biosynthesis in the human central nervous system: structure and function of phosphoserine aminotransferase [PDF]

, 2023
Organisms from all kingdoms of life synthesize L-serine (L-Ser) from 3-phosphoglycerate through the phosphorylated pathway, a three-step diversion of glycolysis.
Campanini B., Costanzi E., Mozzarelli A., Marchesani F., Ullah R., Peracchi A., Murtas G., Bruno S., Storici P., Zangelmi E., Pollegioni L.   +10 more
core   +3 more sources

ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction

Cell Reports, 2021
Summary: The serine synthesis pathway (SSP) involving metabolic enzymes phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine phosphatase (PSPH) drives intracellular serine biosynthesis and is indispensable ...
Xingyao Li, Daniel Gracilla, Lun Cai, Mingyi Zhang, Xiaolin Yu, Xiaoguang Chen, Junran Zhang, Xiaochun Long, Han-Fei Ding, Chunhong Yan   +9 more
doaj   +1 more source

Stabilization of Notch1 and β-catenin in response to ER- breast cancer-specific up-regulation of PSAT1 mediates distant metastasis

Translational Oncology, 2022
Breast cancer has the highest incidence in women worldwide, with a mortality rate second only to lung cancer. Distant metastasis is the major cause of breast cancer-induced death.
Shuxuan Zhu, Xiaoyu Wang, Lei Liu, Guosheng Ren   +3 more
doaj   +1 more source

Aryloxy Triester Phosphoramidates as Phosphoserine Biocleavable Masking Motifs [PDF]

, 2019
Many cellular protein-protein interactions (PPIs) are mediated by phosphoserine. The specific targeting of these PPIs by phosphoserine-containing small molecules has been scarce due to the dephosphorylation of phosphoserine and its charged nature at ...
Olivia A., Lambourne, Edward, James, Youcef, Mehellou, Ageo, Miccoli, Hachemi, Kadri, Binar A., Dhiani, Peter J., Thornton   +6 more
core   +3 more sources

Hepatic Phosphoserine Aminotransferase 1 Regulates Insulin Sensitivity in Mice via Tribbles Homolog 3 [PDF]

Diabetes, 2014
Phosphoserine aminotransferase 1 (PSAT1) is an enzyme participating in serine synthesis. A role of PSAT1 in the regulation of insulin sensitivity, however, is unknown. In this study, we showed that hepatic PSAT1 expression and liver serine levels are reduced in genetically engineered leptin receptor–deficient (db/db) mice and high-fat diet (HFD ...
Junjie, Yu, Fei, Xiao, Yajie, Guo, Jiali, Deng, Bin, Liu, Qian, Zhang, Kai, Li, Chunxia, Wang, Shanghai, Chen, Feifan, Guo   +9 more
openaire   +2 more sources

AMPK-HIF-1α signaling enhances glucose-derived de novo serine biosynthesis to promote glioblastoma growth

Journal of Experimental & Clinical Cancer Research, 2023
Background Cancer cells undergo cellular adaptation through metabolic reprogramming to sustain survival and rapid growth under various stress conditions. However, how brain tumors modulate their metabolic flexibility in the naturally serine/glycine (S/G)-
Hye Jin Yun, Min Li, Dong Guo, So Mi Jeon, Su Hwan Park, Je Sun Lim, Su Bin Lee, Rui Liu, Linyong Du, Seok-Ho Kim, Tae Hwan Shin, Seong-il Eyun, Yun-Yong Park, Zhimin Lu, Jong-Ho Lee   +14 more
doaj   +1 more source

RNA-Seq of Phenotypically Distinct Eimeria maxima Strains Reveals Coordinated and Contrasting Maturation and Shared Sporogonic Biomarkers with Eimeria acervulina

Pathogens, 2023
Strains of Eimeria maxima, an enteric parasite of poultry, vary in virulence. Here, we performed microscopy and RNA sequencing on oocysts of strains APU-1 (which exhibits more virulence) and APU-2.
Matthew S. Tucker, Celia N. O’Brien, Alexis N. Johnson, Jitender P. Dubey, Benjamin M. Rosenthal, Mark C. Jenkins   +5 more
doaj   +1 more source

Investigation Of Phosphoserine Aminotransferase 1 And Its Role In Breast Cancer Progression

The FASEB Journal, 2018
Metastasis and endocrine resistance are two factors that complicate therapeutic intervention in breast cancer patients and lead to poorer overall survival. Metastasis is known to be responsible for 90% of cancer related deaths, and is especially prevalent in triple negative breast cancer (TNBC); while endocrine resistance can ...
Brian Clem, Stephanie Metcalf, Traci Kruer, Carolyn Klinge   +3 more
openaire   +1 more source