Investigation Of Phosphoserine Aminotransferase 1 And Its Role In Breast Cancer Progression
The FASEB Journal, 2018 Metastasis and endocrine resistance are two factors that complicate therapeutic intervention in breast cancer patients and lead to poorer overall survival. Metastasis is known to be responsible for 90% of cancer related deaths, and is especially prevalent in triple negative breast cancer (TNBC); while endocrine resistance can ...
Brian Clem +3 more
openaire +1 more source
Expressions and roles of key enzymes in serine synthesis pathway in NaAsO2-treated HaCaT cells
环境与职业医学, 2022 BackgroundThe key enzymes of serine synthesis pathway (SSP) play an important role in tumor growth, proliferation, and invasion, but their roles in arsenic carcinogenesis are unclear.ObjectiveTo observe the effects of NaAsO2 treatment on the expressions ...
Fengmin LI +5 more
doaj +1 more source
Crystal structure and substrate specificity of the thermophilic serine:pyruvate aminotransferase from Sulfolobus solfataricus. [PDF]
, 2015 Journal ArticleResearch Support, Non-U.S. Gov'tThe three-dimensional structure of the Sulfolobus solfataricus serine:pyruvate aminotransferase has been determined to 1.8 Å resolution.
Bommer, M +4 more
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Targeting PSAT1 to mitigate metastasis in tumors with p53-72Pro variant
Signal Transduction and Targeted Therapy, 2023 The single-nucleotide polymorphism (SNP) of p53, in particular the codon 72 variants, has recently been implicated as a critical regulator in tumor progression. However, the underlying mechanism remains elusive.
Jingwen Jiang +14 more
doaj +1 more source
Transcriptome analysis of primary human oral keratinocytes stimulated with Prevotella melaninogenica
口腔疾病防治, 2022 Objective To investigate the transcriptomic changes in primary human oral keratinocytes (pHOKs) after coculture with Prevotella melaninogenica (P.m) and to verify the changes in human oral keratinocyte (HOK) cell lines.
GUO Yiting +4 more
doaj +1 more source
Cancer metabolism: Addicted to serine. [PDF]
, 2016 Cancer cells are biosynthetic factories that gear multiple metabolic pathways toward cell growth and proliferation. Serine is the metabolite consumed third most by cancer cells, after glucose and glutamine, and is used as a building block for proteins ...
Frezza, Christian
core +2 more sources
Multi-Omics Analyses Detail Metabolic Reprogramming in Lipids, Carnitines, and Use of Glycolytic Intermediates between Prostate Small Cell Neuroendocrine Carcinoma and Prostate Adenocarcinoma. [PDF]
, 2019 As the most common cancer in men, prostate cancer is molecularly heterogeneous. Contributing to this heterogeneity are the poorly understood metabolic adaptations of the two main types of prostate cancer, i.e., adenocarcinoma and small cell ...
Alumkal, Joshi J +8 more
core +1 more source
Scientific Reports, 2020 Phosphoenolpyruvate carboxykinase (PEPCK) is a gluconeogenic enzyme with a cytosolic (Pck1/PEPCK-C) and mitochondrial (Pck2/PEPCK-M) isoform. Here we investigate the effect of 3-mercaptopicolinic acid (3-MPA), a PEPCK inhibitor, on C2C12 muscle cells. We
Madelaine C. Brearley +4 more
doaj +1 more source
Nitrogen Scavengers: History, Clinical Considerations and Future Prospects. [PDF]
J Inherit Metab DisABSTRACT Nitrogen scavengers play a critical role in treating acute and chronic hyperammonemia, especially in urea cycle disorders (UCDs), where impaired ammonia detoxification leads to toxic nitrogen accumulation. These agents complement low‐protein diets and urea cycle intermediates.
Klassa S, Häberle J.
europepmc +2 more sources
Phosphoserine phosphatase is required for serine and one-carbon unit synthesis in Hydrogenobacter thermophilus [PDF]
, 2017 Hydrogenobacter thermophilus is an obligate chemolithoautotrophic bacterium of the phylum Aquificae and is capable of fixing carbon dioxide through the reductive tricarboxylic acid (TCA) cycle.
ARAI, Hiroyuki +9 more
core +1 more source