Results 61 to 70 of about 5,158 (158)

Proteome analysis of multidrug-resistant, breast cancer-derived microparticles [PDF]

, 2014
© 2014 Deep Pokharel et al. Cancer multidrug resistance (MDR) occurswhen cancer cells evade the cytotoxic actions of chemotherapeutics through the active efflux of drugs from within the cells.
Bebawy, M, Djordjevic, SP, Lu, JF, Luk, F, Padula, MP, Pokharel, D, Tacchi, JL   +6 more
core   +2 more sources

Skullcapflavone II Inhibits SLC1A4‐Mediated L‐Serine Uptake and Promotes Mitochondrial Damage in Gastric Cancer

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Skullcapflavone II (SkII) significantly alters serine metabolism in gastric cancer cells by directly targeting the L‐serine transporter SLC1A4, thereby inhibiting L‐serine uptake rather than de novo synthesis. This disruption of serine metabolism by SkII leads to increased oxidative stress and consequent mitochondrial damage.
Jing Zhao, Yu‐Bo Ma, Rui‐Hong Xia, Zheng‐Chen Jiang, Ying Zhou, Ya‐Nan Wang, Meng‐Yan Yang, Jing‐Jie Dai, Tao Zhu, Li‐Bin Pan, Li Yuan   +10 more
wiley   +1 more source

Unfolded protein response kinase PERK supports survival and metastasis of circulating tumor cell clusters via SAM synthesis and H3K4me3‐dependent PDGFB signaling

Cancer Communications, Volume 45, Issue 12, Page 1706-1733, December 2025.
Abstract Background Metastasis is the leading cause of cancer‐related mortality, with circulating tumor cell (CTC) clusters serving as highly efficient precursors of distant metastasis. Survival of CTC clusters in the bloodstream is the primary contributor to tumor metastasis.
Rui Tang, Yan Sun, Ao Deng, Jiahe Liu, Peijin Dai, Jing Chen, Chaoqun Deng, Hui Liu, Yuhang Hai, Yanran Tong, Yan‐e Du, Manran Liu, Haojun Luo   +12 more
wiley   +1 more source

Shmt2: a stat3 signaling new player in prostate cancer energy metabolism [PDF]

, 2019
Prostate cancer (PCa) is a multifactorial disease characterized by the aberrant activity of different regulatory pathways. STAT3 protein mediates some of these pathways and its activation is implicated in the modulation of several metabolic enzymes.
Altieri, Fabio, Chichiarelli, Silvia, Eufemi, Margherita, Giamogante, Flavia, Gurtner, Aymone, Macone, Alberto, Magliocca, Fabio Massimo, Manganaro, Roberto, Maras, Bruno, Marrocco, Ilaria, Paglia, Giuliano, Patsilinakos, Alexandros, Perugia, Giacomo, Ragno, Rino, Rubini, Elisabetta   +14 more
core   +1 more source

Restored microRNA-133a-3p or Depleted PSAT1 Restrains Endothelial Cell Damage-Induced Intracranial Aneurysm Via Suppressing the GSK3β/β-Catenin Pathway

Nanoscale Research Letters, 2020
It is unclear about the functional role of microRNA-133a-3p (miR-133a-3p) in intracranial aneurysm (IA). Hence, the aim of the present study was to investigate the regulatory role of miR-133a-3p on the regulation of vascular endothelial injury-induced IA
Qiang Jia, Shixin Yan, Jie Huang, Shixin Xu   +3 more
doaj   +1 more source

Microbial Cell Factories / Repressible promoters \u2013 A novel tool to generate conditional mutants in Pichia pastoris [PDF]

, 2013
Background: Repressible promoters are a useful tool for down-regulating the expression of genes, especially those that affect cell viability, in order to study cell physiology.
Delic, Marizela, Gasser, Brigitte, Mattanovich, Diethard   +2 more
core   +2 more sources

PSAT1 is upregulated by METTL3 to attenuate high glucose-induced retinal pigment epithelial cell apoptosis and oxidative stress

Diagnostic Pathology
Background Diabetic retinopathy (DR) is a major ocular complication of diabetes mellitus, and a significant cause of visual impairment and blindness in adults. Phosphoserine aminotransferase 1 (PSAT1) is an enzyme participating in serine synthesis, which
Xiaofeng Du, Yanting Wang, Fan Gao
doaj   +1 more source

Effects of the Different Dietary Fish Oil Calcium Salt on Production Performance, Blood Biochemical Parameters, Egg Quality Traits and Yolk Fatty Acid Profile in Laying Hens at Peak Production Period

Veterinary Medicine and Science, Volume 11, Issue 6, November 2025.
Dietary supplementation with fish oil calcium salt improved laying performance, yolk fatty acid profile and egg quality traits during the peak production period. Higher inclusion levels significantly increased n‐3 PUFA content without negative effects on bird health, while moderate levels (0.75%) optimized performance and productivity.
Hamze Ghaderi‐Chaparabad, Seyyed Ali Mirghelenj, Sina Payvastegan, Hamed Khalilvandi‐Behroozyar, Amir Mosayyeb Zadeh   +4 more
wiley   +1 more source

Predicted functional alterations in colonic microbiota metabolism underlie ethanol consumption and preference behavior in mice

Alcohol, Clinical and Experimental Research, Volume 49, Issue 11, Page 2436-2450, November 2025.
Using a free‐choice ethanol model, we show that mice switched from a high‐sugar/butter diet to AIN93G standard diet consume and prefer more alcohol than mice maintained on AIN93G. 16S profiling and inferred metabolome revealed reduced amino acid metabolism, increased secondary bile acid pathways, and lower microbiota‐derived SCFAs and selected amino ...
Mírian Velten Mendes, Thiago Cavalcante Lima, Mariana Siqueira Amormino, Jamil Silvano de Oliveira, Fernanda Lima Alvarenga Barroso, Gaëlle Boudry, Renato Elias Moreira‐Júnior, Ana Lúcia Brunialti‐Godard   +7 more
wiley   +1 more source

Abundance and functional diversity of riboswitches in microbial communities

BMC Genomics, 2007
Background Several recently completed large-scale enviromental sequencing projects produced a large amount of genetic information about microbial communities ('metagenomes') which is not biased towards cultured organisms.
Gelfand Mikhail S, Vitreschak Alexey G, Kazanov Marat D   +2 more
doaj   +1 more source