L-serine and D-serine play crucial roles in the central nervous system (CNS). Indeed, L-serine is a neurotrophic factor and represents the precursor of the neurotransmitters glycine and D-serine, the co-agonists of N-methyl-D-aspartate (NMDA) glutamate ...
MICHIELON, ANNALISA
core
PSAT1 regulates hair follicle growth and stem cell behavior in cashmere goats
Background The Arbas Cashmere Goat from Inner Mongolia is renowned for its superior-quality cashmere, which is primarily produced by secondary hair follicles (SHFs).
Xiao-yu Han +11 more
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Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells [PDF]
International audienceABSTRACT: BACKGROUND: Colorectal cancer (CRC) is one of the most common causes of cancer death throughout the world. In this work our aim was to study the role of the phosphoserine aminotransferase PSAT1 in colorectal cancer ...
Bascoul-Mollevi, Caroline +26 more
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The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang +3 more
wiley +1 more source
Phosphoserine Aminotransferase1 Is Part of the Phosphorylated Pathways for Serine Biosynthesis and Essential for Light and Sugar-Dependent Growth Promotion [PDF]
The phosphorylated pathway of serine biosynthesis represents an important pathway in plants. The pathway consist of three reactions catalyzed by the phosphoglycerate dehydrogenase, the phosphoserine aminotransferase and the phosphoserine phosphatase, and
Stephan Krueger, Sabine Wulfert
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We previously identified PEPCK-M (encoded by the Pck2 gene) to be highly up-regulated in skeletal muscle of pigs treated with Ractopamine, an anabolic beta-adrenergic receptor agonist.
David M Loczenski-Brown +7 more
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Enhanced phosphoserine insertion during Escherichia coli protein synthesis via partial UAG codon reassignment and release factor 1 deletion [PDF]
Genetically encoded phosphoserine incorporation programmed by the UAG codon was achieved by addition of engineered elongation factor and an archaeal aminoacyl-tRNA synthetase to the normal Escherichia coli translation machinery (Park et al., 2011 ...
Isaacs, Farren J. +9 more
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Role of cyclic AMP in the control of cell-specific gene expression [PDF]
Genes have to be expressed in specific cell types at appropriate times of development dependent on external signals. cAMP signaling occurs in all cells, thus raising the question of how this signal transduction pattern is integrated into mechanisms ...
Boshart, Michael +3 more
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miR-424 targets AKT3 and PSAT1 and has a tumor-suppressive role in human colorectal cancer
Yifeng Fang,1 Xiao Liang,1 Junfen Xu,2 Xiujun Cai1 1Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China; 2Department of Gynecologic Oncology, Women’s Hospital, Zhejiang University School
Fang Y, Liang X, Xu J, Cai X
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