Results 71 to 80 of about 5,158 (158)

Evolutionary and functional relationships between plant and microbial C1 metabolism in terrestrial ecosystems

New Phytologist, Volume 248, Issue 3, Page 1132-1153, November 2025.
Summary One‐carbon (C1) metabolism, centered on the universal methyl donor S‐adenosyl methionine (SAM), plays critical roles in biosynthesis, redox regulation, and stress responses across plants and microbes. A recently proposed photosynthetic C1 pathway links SAM methyl groups directly to RuBisCO‐mediated CO2 assimilation and integrates with nitrogen ...
Kolby J. Jardine, Linnea K. Honeker, Zhaoxin Zhang, Steve Kwatcho Kengdo, Yuguo Yang, Joseph Roscioli, William J. Riley   +6 more
wiley   +1 more source

Interplay between acetylation and ubiquitination controls PSAT1 protein stability in lung adenocarcinoma

Communications Biology
Serine is essential to maintain maximal growth and proliferation of cancer cells by providing adequate intermediate metabolites and energy. Phosphoserine aminotransferase 1 (PSAT1) is a key enzyme in de novo serine synthesis.
Yuhan Liu, Wenze Xun, Tao Zhao, Menglin Huang, Longhua Sun, Guilan Wen, Xiuhua Kang, Jianbin Wang, Tianyu Han   +8 more
doaj   +1 more source

Activation of Serine One-Carbon Metabolism by Calcineurin A beta 1 Reduces Myocardial Hypertrophy and Improves Ventricular Function [PDF]

, 2017
Background In response to pressure overload, the heart develops ventricular hypertrophy that progressively decompensates and leads to heart failure.
Acin-Perez, R, Antonio Enriquez, J, Bonzon-Kulichenko, E, Cogliati, S, Garcia-Pavia, P, Gomez-Salinero, JM, Lara-Pezzi, E, Lopez-Olaneta, M, Ortiz-Sanchez, P, Padron-Barthe, L, Rosenthal, N, Vazquez, J, Villalba-Orero, M   +12 more
core   +1 more source

Seizures and electroencephalographic findings in inborn errors of metabolism: Clues to differential diagnosis in the neonatal period, infancy, childhood and adolescence, and review of the literature

Epileptic Disorders, Volume 27, Issue 5, Page 745-802, October 2025.
Abstract Although inborn errors of metabolism (IEM) are a rare cause of epilepsy, seizures are a common presentation in these disorders. Seizures in IEM are frequently refractory to conventional anti‐seizure medication and might warrant initiation of specific treatments based on vitamins or dietary modifications or provision of alternative substrates ...
D. Kapoor, S. Sharma, A. Kaminska, R. Nabbout, N. Chemaly, M. Schiff, P. De Lonlay, M. Eisermann   +7 more
wiley   +1 more source

Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof‐of‐concept clinical study

Epilepsia, Volume 66, Issue 10, Page 3769-3784, October 2025.
Abstract Objective Drug‐resistant epilepsy (DRE) affects >25 million people worldwide and is often associated with neuroinflammation. Increasing evidence links deficiency or malfunctioning of the enzyme phosphoglycerate dehydrogenase (PHGDH), which converts 3‐phosphoglycerate to generate serine and the neurotransmitter glycine, with (drug‐resistant ...
Karin Thevissen, Annelii Ny, Daniëlle Copmans, Jana Tits, Kenichi Kamata, Eva Gielis, Kevin Longin, Jo Sourbron, Peravina Thergarajan, Tracie Huey‐Lin Tan, Idrish Ali, Nigel C. Jones, Terence J. O'Brien, Mastura Monif, Bridgette D. Semple, Christine Germeys, Benedetta Frizzi, Virginia Minniti, Sebastian Perrone, Carole L. Linster, Ilaria Elia, Ludo Van Den Bosch, Bruno P. A. Cammue, Arnout Voet, Lieven Lagae, Peter de Witte   +25 more
wiley   +1 more source

Apolipoprotein M (ApoM) Ameliorates Acute Alcohol Intoxication (AAI)‐Hemorrhagic Shock and Resuscitation (HSR)‐Induced Microvascular Leakage

Microcirculation, Volume 32, Issue 7, October 2025.
ABSTRACT Objective Microvascular hyperpermeability is a serious complication that occurs from hemorrhagic shock and resuscitation (HSR), especially when combined with acute alcohol intoxication (AAI). We tested the hypothesis that administration of Apolipoprotein M (ApoM), a lipocalin that normally resides in plasma high‐density lipoproteins (HDL) and ...
Mengmeng Chang, Jerome W. Breslin
wiley   +1 more source

PSAT1 regulates hair follicle growth and stem cell behavior in cashmere goats

BMC Veterinary Research
Background The Arbas Cashmere Goat from Inner Mongolia is renowned for its superior-quality cashmere, which is primarily produced by secondary hair follicles (SHFs).
Xiao-yu Han, Jia-ning Liu, Nan-xiang Sun, Yin-xian Zhang, Hao-bing Bai, Wei-guo Song, Xiao Hu, Hao Liang, Xiong Miao, Yun-mei He, Dong-jun Liu, Xu-dong Guo   +11 more
doaj   +1 more source

Effect of temperature on Burkholderia pseudomallei growth, proteomic changes, motility and resistance to stress environments. [PDF]

, 2018
Burkholderia pseudomallei is a flagellated, gram-negative environmental bacterium that causes melioidosis, a severe infectious disease of humans and animals in tropical areas. We hypothesised that B.
Chantratita, Narisara, Paksanont, Suporn, Peacock, Sharon J, Pumirat, Pornpan, Sintiprungrat, Kitisak, Yimthin, Thatcha   +5 more
core   +1 more source

Metabolic Reprogramming of Cancer Cells and Therapeutics Targeting Cancer Metabolism

Cancer Medicine, Volume 14, Issue 18, September 2025.
ABSTRACT Background Cancer metabolism is a field focused on the unique alterations in metabolic pathways that occur in cancer cells, distinguishing them from the metabolic processes in normal cells. Methods An extensive review of the current literature on the metabolic adaptation of cancer cells was carried out in the current study. Results The rapidly
Jilsy M. J. Punnasseril, Abdul Auwal, Vinod Gopalan, Alfred King‐Yin Lam, Farhadul Islam   +4 more
wiley   +1 more source

The impact of growth promoters on muscle growth and the potential consequences for meat quality [PDF]

, 2016
To meet the demands of increased global meat consumption, animal production systems will have to become more efficient, or at least maintain the current efficiency utilizing feed ingredients that are not also used for human consumption.
Aalhus, Adeola, Altarejos, Beermann, Beermann, Bodine, Bohorov, Boisclair, Brameld, Brameld, Brooke, Brown, Bush, Casas, Choe, Ciobanu, Clemmons, Coux, Cruzen, Daughaday, David M. Brown, Denley, Douillard, Duckett, Dunshea, Dunshea, Etherton, Etherton, FAO, Foresight, Fuentes-Prior, Geesink, Glass, Godfray, Goll, Goll, Goncalves, Gunawan, Hemmings, Henckel, Higgins, Hocquette, Hopkins, Houbak, Huang, Huang, John M. Brameld, Karlsson, Kemp, Kemp, Kevin J.P. Ryan, Kim, Kim, Koohmaraie, Koopman, Kretchmar, Krick, Krystal M. Hemmings, Lamare, Lametsch, Larzul, Lefaucheur, Liang, Mareko, Mareko, McNeel, Meersman, Mills, Molebeledi H.D. Mareko, Nonneman, Oksbjerg, Ouali, Page, Parr, Parr, Parr, Patience, Peters, Renand, Robert, Ryan, Ryu, Schiaffino, Sensky, Sentandreu, Seppelt, Siegel, Solomon, Taillandier, Tang, Taylor, Taylor, Tim Parr, Tomas, Underwood, Vann, Velloso, Wang, Wendt, Wheeler, Whipple, White   +101 more
core   +1 more source