Results 61 to 70 of about 22,858 (260)

PI5P4K inhibitors: promising opportunities and challenges

The FEBS Journal, EarlyView.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi, Lisa Nagase, Shun Kageyama, Hirotaka Kanoh, Masashi Oshima, Aki Ogawa‐Iio, Yoshiki Ikeda, Yuki Fujii, Sei Kondo, Natsuki Osaka, Takeshi Masuda, Tsukasa Ishihara, Yoshikazu Nakamura, Yoshihisa Hirota, Takehiko Sasaki, Toshiya Senda, Atsuo T. Sasaki   +16 more
wiley   +1 more source

Self-Assembled Supramolecular Nanoparticles Improve the Cytotoxic Efficacy of CK2 Inhibitor THN7

Pharmaceuticals, 2018
Since the approval of imatinib in 2001, kinase inhibitors have revolutionized cancer therapies. Inside this family of phosphotransferases, casein kinase 2 (CK2) is of great interest and numerous scaffolds have been investigated to design CK2 inhibitors ...
Abdelhamid Nacereddine, Andre Bollacke, Eszter Róka, Christelle Marminon, Zouhair Bouaziz, Ferenc Fenyvesi, Ildikó Katalin Bácskay, Joachim Jose, Florent Perret, Marc Le Borgne   +9 more
doaj   +1 more source

Measuring catalytic mechanism similarity – a new approach to study enzyme function and evolution

The FEBS Journal, EarlyView.
We introduce a previously undescribed computational method to measure the similarity of enzyme mechanisms, enabling comparison of catalytic steps across hundreds of enzymes. Applying this method to a database of enzyme mechanisms demonstrated its ability to automatically uncover functional and evolutionary relationships, independently of sequence and ...
Antonio J. M. Ribeiro, Ioannis G. Riziotis, Neera Borkakoti, Pedro A. Fernandes, Maria J. Ramos, Janet M. Thornton   +5 more
wiley   +1 more source

Characterization of the Microbial Resistome in Conventional and “Raised Without Antibiotics” Beef and Dairy Production Systems

Frontiers in Microbiology, 2019
Metagenomic investigations have the potential to provide unprecedented insights into microbial ecologies, such as those relating to antimicrobial resistance (AMR).
Pablo Rovira, Tim McAllister, Steven M. Lakin, Shaun R. Cook, Enrique Doster, Noelle R. Noyes, Maggie D. Weinroth, Xiang Yang, Jennifer K. Parker, Christina Boucher, Calvin W. Booker, Dale R. Woerner, Keith E. Belk, Paul S. Morley   +13 more
doaj   +1 more source

Pathological significance of intranuclear structures in liver biopsy samples

Hepatology Research, EarlyView.
Schematic representation of the potential significance of three distinct nuclear structures. Glycogenated nuclei reflects excessive glycogen accumulation in the hepatocytes. Nucleoplasmic lipid droplets form in the nucleus during hepatocyte injury. Cytoplasmic lipid droplets in the nucleoplasmic reticulum are suppressed when there is excessive fat ...
Norihiro Imai, Yuki Ohsaki, Jinglei Cheng, Hanna Kawecka, Jingjing Zhang, Fumitaka Mizuno, Taku Tanaka, Shinya Yokoyama, Kenta Yamamoto, Takanori Ito, Yoji Ishizu, Takashi Honda, Tetsuya Ishikawa, Michał Woźniak, Hiroaki Wake, Hiroki Kawashima   +15 more
wiley   +1 more source

Identification of Primary Antimicrobial Resistance Drivers in Agricultural Nontyphoidal Salmonella enterica Serovars by Using Machine Learning

mSystems, 2019
Nontyphoidal Salmonella (NTS) is a leading global cause of bacterial foodborne morbidity and mortality. Our ability to treat severe NTS infections has been impaired by increasing antimicrobial resistance (AMR).
Finlay Maguire, Muhammad Attiq Rehman, Catherine Carrillo, Moussa S. Diarra, Robert G. Beiko   +4 more
doaj   +1 more source

Old player, new roles: defining the role of the plastidial phosphorylase

New Phytologist, EarlyView.
Summary The plastidial phosphorylase (Pho1 or Phs1; E.C. 2.4.1.1) is a ubiquitous enzyme among plants that catalyzes the formation and degradation of glucans. Although the first report connecting Pho1 with starch metabolism came out > 80 years ago, its precise role is still a matter of debate.
David Seung, Slawomir Orzechowski, Joerg Fettke   +2 more
wiley   +1 more source

Mechanisms governing bacterial capsular polysaccharide attachment and chain length

Annals of the New York Academy of Sciences, EarlyView.
Abstract Capsular polysaccharides (CPSs) are high‐molecular weight glycopolymers that form a capsule layer on the surface of many bacterial species. This layer serves as a crucial barrier between bacteria and their environment, protecting them from host immune responses and environmental stressors while facilitating adaptation to host niches.
Saroj Khadka, Emily L. Kinney, Brooke E. Ryan, Laura A. Mike   +3 more
wiley   +1 more source

Phospholipid and cation activation of chimaeric choline/ethanolamine phosphotransferases.

Biochemical Journal, 1996
The Saccharomyces cerevisiae CPT1 and EPT1 genes encode for a cholinephosphotransferase (CPT) and choline/ethanolaminephosphotransferase, respectively. Both Cpt1p and Ept1p activities display an absolute requirement for cations and phospholipids. A mixed-
C. McMaster, S. C. Morash, R. Bell
semanticscholar   +1 more source

Synthetic photorespiratory bypass more stably increases potato yield per plant by improving photosynthesis

Plant Biotechnology Journal, EarlyView.
Summary The bioengineering of photorespiration has emerged as a key target for improving photosynthesis and crop yield. In our previous study, two photorespiratory bypasses, GOC and GCGT, were successfully established in rice, and the transgenic plants exhibited increased photosynthesis and yield.
Xiuling Lin, Yuming Long, Zhen Yao, Boran Shen, Min Lin, Xiaofen Zhong, Xiaohong Chen, Xiangyang Li, Guohui Zhu, Zhisheng Zhang, Xinxiang Peng   +10 more
wiley   +1 more source