Results 61 to 70 of about 12,020 (216)

Genome‐Wide Association Study Elucidates the Genetic Architecture of Manganese Tolerance in Brassica napus

open access: yesPlant, Cell &Environment, EarlyView.
ABSTRACT Brassica napus (canola) is a significant contributor to the world's oil production and is cultivated across continents, yet acidic soils with aluminium (Al3+) and manganese (Mn2+) toxicities limit its production. The genetic determinants underlying natural variation for acidic soil tolerance in canola are unknown and need to be determined ...
Harsh Raman   +13 more
wiley   +1 more source

Hydroxysteroid 17β‐dehydrogenase 13 (Hsd17b13) knockdown attenuates liver steatosis in high‐fat diet obese mice

open access: yesExperimental Physiology, EarlyView.
Abstract Hydroxysteroid 17β‐dehydrogenase 13 (HSD17B13) loss‐of‐function gene variants are associated with a decreased risk of metabolic dysfunction‐associated steatotic liver disease (MASLD). Our RNA‐seq analysis of steatotic liver from obese mice ± fenretinide treatment identified major beneficial effects of fenretinide on expression of hepatic genes
Shehroz Mahmood   +8 more
wiley   +1 more source

Glucose-1-phosphotransferase and N-acetylglucosamine-1-phosphotransferase have distinct acceptor specificities.

open access: yesJournal of Biological Chemistry, 1987
UDP-glucose:glycoprotein glucose-1-phosphotransferase (Glc-phosphotransferase) catalyzes the transfer of alpha Glc-1-P from UDP-Glc to endoglycosidase H-sensitive oligosaccharides on acceptor glycoproteins. We have previously demonstrated that Glc-phosphotransferase was specific for UDP-Glc as its nucleotide sugar substrate and thus appeared to be ...
Richard B. Marchase   +2 more
openaire   +3 more sources

Fructose catabolism and its metabolic effects: Exploring host–microbiota interactions and the impact of ethnicity

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend This graphical abstract is a schematic representation highlighting the interactions between dietary fructose, gut microbiota and ethnicity in shaping metabolic health. Abstract Important health disparities are observed in the prevalence of obesity and associated non‐communicable diseases (NCDs), including type 2 diabetes (T2D ...
Florine H.M. Westerbeke   +3 more
wiley   +1 more source

Non‐Membrane Active Peptide Resensitizes MRSA to β‐Lactam Antibiotics and Inhibits S. aureus Virulence

open access: yesAdvanced Science, Volume 12, Issue 15, April 17, 2025.
This work identifies a potent, non‐membrane active, and non‐toxic AMP termed GN1, which substantially resensitizes MRSA to multiple β‐lactam antibiotics at low concentrations. GN1 functions by suppressing MRSA‐associated resistance determinants, including penicillin‐binding protein 2a (PBP2a) and β‐lactamase.
Jingru Shi   +6 more
wiley   +1 more source

A Synthetic Facultative CAM‐Like Shuttle in C3 Rice Plants

open access: yesAdvanced Science, Volume 12, Issue 13, April 3, 2025.
This study utilizes gene editing and multigene stacking to design a facultative CAM‐like metabolic pathway that includes a stomatal regulation module, a carboxylation module, a decarboxylation module, and a malate transport module. A facultative CAM‐like metabolic pathway is created in C₃ rice, achieving compatibility between the C₃ cycle and the CAM ...
Suting Wu   +12 more
wiley   +1 more source

The Transport of Carbohydrates by a Bacterial Phosphotransferase System [PDF]

open access: yesThe Journal of General Physiology, 1969
The components and properties of a phosphoenolpyruvate: glucose phosphotransferase system are reviewed, along with the evidence implicating this system in sugar transport across bacterial membranes. Some possible physiological implications of sugar transport mediated by the phosphotransferase system are also considered.
openaire   +3 more sources

High‐Throughput Culture and DNA Isolation Methods for Aspergillus fumigatus

open access: yesCurrent Protocols, Volume 5, Issue 4, April 2025.
Abstract Aspergillus fumigatus is an opportunistic human fungal pathogen that is widely spread in the environment. The need to screen a large number of environmental or clinical isolates for phenotypic and/or genotypic purposes can be challenging and time consuming when using the protocols that are currently available.
Francisca C. Reyes Márquez   +3 more
wiley   +1 more source

Exploring the potential mechanisms of polysaccharides against gastric ulcer: Network pharmacology analysis and molecular docking validation

open access: yesFood Safety and Health, Volume 3, Issue 2, Page 232-249, April 2025.
Predicting the mechanisms of polysaccharides against gastric ulcer. Abstract Gastric ulcer is a common peptic ulcer that affects human health and life quality seriously. As anti‐gastric ulcer drugs usually cause side‐effects, polysaccharides may be the potential alternatives because of better effectiveness and less toxicity.
Jia‐Yu Huang   +9 more
wiley   +1 more source

Phosphatidic acid phosphatase LPIN1 in phospholipid metabolism and stemness in hematopoiesis and AML

open access: yesHemaSphere, Volume 9, Issue 4, April 2025.
Abstract Targeting metabolism represents a promising approach to eradicate leukemic stem cells (LSCs) that are considered critical drivers of relapse in acute myeloid leukemia (AML). In this study, we demonstrate that the phosphatidic acid phosphatase LPIN1, which regulates the synthesis of diacylglycerol, the key substrate for triacylglycerol, and ...
Karin Huber   +18 more
wiley   +1 more source

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