Predisposing deleterious variants in the cancer-associated human kinases in the global populations.
PLoS ONEHuman kinases play essential and diverse roles in the cellular activities of maintaining homeostasis and growth. Genetic mutations in the genes encoding the kinases (or phosphotransferases) have been linked with various types of cancers.
Salman Ahmed Khan +6 more
doaj +1 more source
Gene Editing and Transformation Strategies for Engineering Drought‐Tolerant Legumes
Legume Science, Volume 8, Issue 1, March 2026.ABSTRACT Legumes play a vital role in agriculture, nutrition, and the economy, but their production faces significant threats. Among these, drought and its unpredictability will be the most damaging constraint in the coming decades. Enhancing drought tolerance is essential for resilient and sustainable legume cultivation, and genetic engineering ...
Andrea Fernandez‐Gutierrez +2 more
wiley +1 more source
Conformational dynamics in insulin receptor kinase reveal a type III allosteric pocket
Protein Science, Volume 35, Issue 2, February 2026.Abstract Allosteric modulation is a promising strategy for selective kinase inhibition, yet structural insights into allosteric pockets remain limited across the human kinome. In this work, we present comprehensive characterization of a type III allosteric pocket in the insulin receptor kinase (IRK), integrating structural, conformational, and ...
Jyoti Verma, Harish Vashisth
wiley +1 more source
Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria
Microbiological Reviews, 1993 Numerous gram-negative and gram-positive bacteria take up carbohydrates through the phosphoenolpyruvate (PEP):carbohydrate phosphotransferase system (PTS). This system transports and phosphorylates carbohydrates at the expense of PEP and is the subject of this review.
P W, Postma +2 more
openaire +2 more sources
Journal of the World Aquaculture Society, Volume 57, Issue 1, February 2026.Abstract Members of Bacillus cereus have been documented as important bacterial pathogens in aquaculture. However, scarce information is available on B. cereus isolates as causal pathogens of big‐belly seahorses Hippocampus abdominalis. In the present study, a B. cereus isolate (SH1), recovered from a disease outbreak on a seahorse farm, was identified
Chunlei Gai +7 more
wiley +1 more source
Phospholipid Interconversion and Transport Are Altered in Glaucoma
The FASEB Journal, Volume 40, Issue 2, 31 January 2026.Decreased phosphatidylserine (PS) and increased phosphatidylethanolamine (PE) occur in both trabecular meshwork (TM) cells and aqueous humor due to aberrant phosphatidylserine decarboxylase (PSD) over‐expression, and variation in levels of individual PS or PE species differing by only a few acyl chains occurs due to impaired lipid transport due to ...
Genea Edwards +5 more
wiley +1 more source
Yeast Phosphoramidate-Adenosine Diphosphate Phosphotransferase
Journal of Biological Chemistry, 1968 Abstract An enzyme, phosphoramidate-ADP phosphotransferase, has been isolated from dried bakers' yeast. We have previously shown that phosphoramide, N-phosphorylglycine, and N-phosphohistidine can act as phosphate donors. Phosphoiodohistidine was shown also to function as a phosphate donor and the enzyme was stereospecific for the l form of this ...
M J, Dowler, H I, Nakada
openaire +2 more sources
Why the Phosphotransferase System of Escherichia coli Escapes Diffusion Limitation [PDF]
, 2003 Christof Francke +4 more
openalex +1 more source
Adenylate cyclase is required for chemotaxis to phosphotransferase system sugars by Escherichia coli [PDF]
, 1983 Roy A. Black, A C Hobson, Julius Adler
openalex +1 more source
Fructose-specific phosphoenolpyruvate dependent phosphotransferase system ofEscherichia coli: its alterations and adenylate cyclase activity [PDF]
, 1989 V.N. Gershanovitch +6 more
openalex +1 more source