Results 41 to 50 of about 11,871 (215)
Crystal structures of two aminoglycoside kinases bound with a eukaryotic protein kinase inhibitor. [PDF]
PLoS ONE, 2011 Antibiotic resistance is recognized as a growing healthcare problem. To address this issue, one strategy is to thwart the causal mechanism using an adjuvant in partner with the antibiotic.
Desiree H Fong +3 more
doaj +1 more source
Aminoglycoside 3'-phosphotransferase III, a new phosphotransferase. Resistance mechanism.
The Journal of Antibiotics, 1975 The aminoglycoside phosphotransferase of Pseudomonas aeruginosa 21-75 was purified by affinity chromatography using dibekacin-Sephadex 4B or lividomycin A-Sepharose 4B followed by DEAE Sephadex A-50 chromatography. It had activities of both the known aminoglycoside 3'-phosphotransferases I and II, and transferred phosphate from ATP to the 3'-hydroxyl ...
YOJI UMEZAWA +6 more
openaire +3 more sources
Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance
Frontiers in Cellular and Infection Microbiology, 2013 Aminoglycosides are a class of antibiotics with a broad spectrum of antimicrobial activity. Unfortunately, resistance in clinical isolates is pervasive, rendering many aminoglycosides ineffective.
Kun eShi +4 more
doaj +1 more source
Identifcation of small molecule enzyme inhibitors as broad-spectrum anthelmintics [PDF]
, 2019 Targeting chokepoint enzymes in metabolic pathways has led to new drugs for cancers, autoimmune disorders and infectious diseases. This is also a cornerstone approach for discovery and development of anthelmintics against nematode and flatworm parasites.
Aroian, Raffi V. +10 more
core +3 more sources
Enzymes are enriched in bacterial essential genes.
PLoS ONE, 2011 Essential genes, those indispensable for the survival of an organism, play a key role in the emerging field, synthetic biology. Characterization of functions encoded by essential genes not only has important practical implications, such as in identifying
Feng Gao, Randy Ren Zhang
doaj +1 more source
Relating the metatranscriptome and metagenome of the human gut [PDF]
, 2014 Although the composition of the human microbiome is now wellstudied, the microbiota’s \u3e8 million genes and their regulation remain largely uncharacterized.
Boylan, Matthew R. +13 more
core +2 more sources
Scientific Reports, 2023 The ocular surface (OS) enzymes are of great interest due to their potential for novel ocular drug development. We aimed first to profile and classify the enzymes of the OS to describe major biological processes and pathways that are involved in the ...
Murat Akkurt Arslan +6 more
doaj +1 more source
Purification and characterization of a hygromycin B phosphotransferase from Streptomyces hygroscopicus [PDF]
, 1987 4 pages, 4 figures, 1 table, 20 references.A hygromycin B phosphotransferase activity from Streptomyces hygroscopicus has been highly purified by ammonium sulphate fractionation followed by affinity column chromatography through Sepharose-6B- hygromycin ...
Jiménez Díaz, Antonio +2 more
core +1 more source
Molecules, 2018 Phosphoserine phosphatase (PSP), a member of the haloacid dehalogenase (HAD) superfamily that comprises the vast majority of phosphotransferases, is likely a steady-state regulator of the level of d-serine in the brain.
Dieter Krachtus +2 more
doaj +1 more source
Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline [PDF]
, 2016 Acknowledgments We would like to gratefully acknowledge all donors and their families for the tissue provided for this study. Human tissue samples were supplied by the Brains for Dementia Research programme, jointly funded by Alzheimer’s Research UK, the
Cranston, Anna +5 more
core +3 more sources