Results 31 to 40 of about 9,693 (136)

Enzymes are enriched in bacterial essential genes.

open access: yesPLoS ONE, 2011
Essential genes, those indispensable for the survival of an organism, play a key role in the emerging field, synthetic biology. Characterization of functions encoded by essential genes not only has important practical implications, such as in identifying
Feng Gao, Randy Ren Zhang
doaj   +1 more source

Profiling tear film enzymes reveals major metabolic pathways involved in the homeostasis of the ocular surface

open access: yesScientific Reports, 2023
The ocular surface (OS) enzymes are of great interest due to their potential for novel ocular drug development. We aimed first to profile and classify the enzymes of the OS to describe major biological processes and pathways that are involved in the ...
Murat Akkurt Arslan   +6 more
doaj   +1 more source

Quantum Mechanical/Molecular Mechanical Analysis of the Catalytic Mechanism of Phosphoserine Phosphatase

open access: yesMolecules, 2018
Phosphoserine phosphatase (PSP), a member of the haloacid dehalogenase (HAD) superfamily that comprises the vast majority of phosphotransferases, is likely a steady-state regulator of the level of d-serine in the brain.
Dieter Krachtus   +2 more
doaj   +1 more source

Association of Diet and Antimicrobial Resistance in Healthy U.S. Adults

open access: yesmBio, 2022
Antimicrobial resistance (AMR) represents a significant source of morbidity and mortality worldwide, with expectations that AMR-associated consequences will continue to worsen throughout the coming decades.
Andrew Oliver   +12 more
doaj   +1 more source

Glyoxalase I gene deletion mutants of Leishmania donovani exhibit reduced methylglyoxal detoxification. [PDF]

open access: yesPLoS ONE, 2009
BACKGROUND:Glyoxalase I is a metalloenzyme of the glyoxalase pathway that plays a central role in eliminating the toxic metabolite methyglyoxal. The protozoan parasite Leishmania donovani possesses a unique trypanothione dependent glyoxalase system ...
Swati C Chauhan, Rentala Madhubala
doaj   +1 more source

Analysis of somatic mutations across the kinome reveals loss-of-function mutations in multiple cancer types

open access: yesScientific Reports, 2017
In this study we use somatic cancer mutations to identify important functional residues within sets of related genes. We focus on protein kinases, a superfamily of phosphotransferases that share homologous sequences and structural motifs and have many ...
Runjun D. Kumar, Ron Bose
doaj   +1 more source

AMINOGLYCOSIDE RESISTANCE GENES IN Pseudomonas aeruginosa ISOLATES FROM CUMANA, VENEZUELA

open access: yesRevista do Instituto de Medicina Tropical de São Paulo, 2016
The enzymatic modification of aminoglycosides by aminoglycoside-acetyltransferases (AAC), aminoglycoside-adenyltransferases (AAD), and aminoglycoside-phosphotransferases (APH), is the most common resistance mechanism in P.
Bertinellys TEIXEIRA   +5 more
doaj   +1 more source

Protective effects of adiponectin receptor agonists against equine lamellar endoplasmic reticulum stress

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Lamellar endoplasmic reticulum (ER) stress occurs in hyperinsulinemia‐associated and sepsis‐related laminitis. Adiponectin is associated with reduced laminitis risk and inhibits ER stress in other species. Objectives To induce ER stress in ex vivo equine lamellar cells using pharmacological agents.
Marine A. Barnabé   +6 more
wiley   +1 more source

Stage‐Dependent Metabolic Reprogramming Drives a Self‐Organizing Microbial Network During Shanxi Aged Vinegar

open access: yesFood Bioengineering, EarlyView.
Metabolic shifts from growth to stress adaptation in Shanxi aged vinegar fermentation link flavor maturation and microbial cooperation, and Lactobacillus and Acetobacter form a self‐organizing metabolic network through division of labor. ABSTRACT Acetic acid fermentation (AAF) is a vital stage in the production of Shanxi aged vinegar (SAV), during ...
Yanfang Wu   +6 more
wiley   +1 more source

Structural basis for catalysis and selectivity of phospholipid synthesis by eukaryotic choline-phosphotransferase

open access: yesNature Communications
Phospholipids are the most abundant component in lipid membranes and are essential for the structural and functional integrity of the cell. In eukaryotic cells, phospholipids are primarily synthesized de novo through the Kennedy pathway that involves ...
Jacquelyn R. Roberts   +10 more
doaj   +1 more source

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