Results 21 to 30 of about 9,664 (151)
Plant Biotechnology Journal, Volume 24, Issue 7, Page 4577-4598, July 2026.ABSTRACT Cold stress threatens wheat productivity, particularly in regions with extreme climatic conditions. To elucidate the molecular mechanisms underlying wheat's response to cold stress, we performed a multiomics analysis integrating lipidomics, transcriptomics, proteomics and metabolomics.
Sofora Jan +15 more
wiley +1 more source
Plant, Cell &Environment, Volume 49, Issue 7, Page 3543-3559, July 2026.ABSTRACT Isoflavones, secondary metabolites with numerous health benefits, are predominantly found in legume seeds, especially soybean; however, their contents in domesticated soybean seeds are highly variable. Wild soybeans are known for higher seed isoflavone contents than cultivars. Here we used experimental and modelling approaches on wild soybean (
Carolina A. Contador +5 more
wiley +1 more source
Bioconjugation Strategies for Revealing the Roles of Glycerophospholipids in Cells
ChemBioChem, Volume 27, Issue 11, 15 June 2026.Glycerophospholipids are the main class of phospholipids, essential for membrane structure, compartmentalization, and cellular signaling. To study their roles, innovative probes and advanced bioconjugation strategies have been developed, including by de novo lipid synthesis and bioorthogonal conjugation chemistry.
Brice Beauvais +5 more
wiley +1 more source
Kinetic Fingerprints as Mechanistic and Clinical Roadmaps Across KIT Activation States
ChemMedChem, Volume 21, Issue 11, 15 June 2026.Kinetic profiling of 172 compounds across KIT conformations—including D816V—reveals kinetic fingerprints that predict efficacy, selectivity, resistance, and inhibitors’ ability to stabilize key regulatory elements. Far from a secondary metric, binding kinetics provide mechanistic insights beyond affinity, offering a powerful framework for rational drug
Ana Corrionero +7 more
wiley +1 more source
Advanced Science, Volume 13, Issue 34, 19 June 2026.This study designs a targeted nanocomposite (ct@HMCF‐Dex) that responds to acidic infection microenvironments, releasing components which amplify oxidative stress. It disrupts bacterial redox balance, chelates metals to sustain lipid peroxidation, and synergistically induces cuproptosis/ferroptosis‐like death.
Zehui Xiao +6 more
wiley +1 more source
Severe Restriction of Glucose Import Enhances Recombinant Protein Production in Escherichia coli
Biotechnology Journal, Volume 21, Issue 6, June 2026.Graphical Abstract and Lay Summary Producing recombinant proteins in Escherichia coli is often limited by the bacterium's tendency to consume glucose too rapidly. This excessive glucose uptake causes overflow metabolism, leading to the accumulation of acetate, a byproduct that can reduce cellular performance and protein production.
Juan Carlos Fragoso‐Jiménez +5 more
wiley +1 more source
Genetically Programmed Control of Overflow Metabolism
Biotechnology and Bioengineering, Volume 123, Issue 6, Page 1624-1633, June 2026.ABSTRACT Overflow metabolism is a highly undesirable phenomenon that occurs in virtually all cell factories. Although several schemes have been applied to avoid overflow metabolism, this problem remains far from being solved. In this study, a genetic sensor for detecting overflow metabolism was designed, and its substrate specificity and reversibility ...
Lærke M. Jensen +3 more
wiley +1 more source
Vicatia thibetica de Boiss Crude Polysaccharide Delay the Aging of the Heart and Kidneys
Food Bioengineering, Volume 5, Issue 2, Page 278-289, June 2026.Vicatia thibetica de Boiss crude polysaccharide (VTCP) attenuates cardiorenal aging by reducing oxidative stress, suppressing inflammation, and alleviating fibrosis. In naturally aged mice, VTCP remodels the gut microbiota, enriching beneficial short‐chain fatty acid‐producing bacteria. We propose that VTCP protects the heart and kidneys via modulation
Daoxu Zhang +14 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 6, June 2026.Time‐dependent fermentation caused dynamic changes in the bioactive constituents of white corn steep liquor and improved its antioxidant, antidiabetic, and antiobesogenic activities in vitro. ABSTRACT The present study investigated the effect of crude fermentation on white corn steep liquor and its bioactive constituents in the management of metabolic ...
Lemohang Gumenku +5 more
wiley +1 more source
Under the Cover of Darkness: A Transcriptomic Exploration of Clubroot During the Night
Plant Direct, Volume 10, Issue 6, June 2026.ABSTRACT Plasmodiophora brassicae (Phytomyxea, Rhizaria) is the etiological agent of clubroot disease, one of the most important diseases of Brassicaceae crops. Alteration of metabolism and hormone homeostasis leads to the formation of tumor‐like galls in the roots of affected plants.
Andrea Garvetto +5 more
wiley +1 more source