Results 11 to 20 of about 9,664 (151)

Functional characterization of 42 CK2α de novo variants associated with Okur‐Chung neurodevelopmental syndrome

The FEBS Journal, EarlyView.
Okur‐Chung neurodevelopmental syndrome (OCNDS) is a neurodevelopmental disorder associated with mutations in the gene coding for Protein kinase CK2α. In this work, 42 variants of CK2α associated with OCNDS were characterized in vitro. This included determination of catalytic activity and CK2α/CK2β‐interaction as well as an assessment of evolutionary ...
Alexander Gast, Christian Werner, Karsten Niefind, Joachim Jose   +3 more
wiley   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Arabidopsis inositol polyphosphate kinase activities regulate COP9 deneddylation functions in phosphate homeostasis

Journal of Integrative Plant Biology, EarlyView.
Plant phosphate (Pi) homeostasis relies on coordinated activities of the inositol polyphosphate kinases IPK1 and ITPK1, which balance localized InsP7 biosynthesis to control COP9 signalosome (CSN)‐dependent deneddylation of cullin 1 (CUL1). Perturbation of this equilibrium affects the stability of SPX4, a key negative regulator of phosphate starvation ...
Yashika Walia, Medha Noopur, Ishana Bhattacharya, Bhaskar Chandra Sahoo, Mritunjay Kasera, Naga Jyothi Pullagurla, Smritikana Dutta, Guizhen Liu, Gabriel Schaaf, Henning Jessen, Debabrata Laha, Souvik Bhattacharjee, Saikat Bhattacharjee   +12 more
wiley   +1 more source

In Salmonella Typhimurium, YiiD Modulates cAMP Levels in Lag Phase During Growth on Succinate

Molecular Microbiology, EarlyView.
The YiiD enzyme, found by others to perform a redundant role in fatty acid biosynthesis, is found to be unexpectedly required for the early increase in cAMP in lag phase during growth on succinate. This intriguing finding suggests a mechanistic link may exist between fatty acid biosynthesis and catabolite repression. ABSTRACT In Salmonella Typhimurium (
John A. Ciemniecki, Jessica L. Will, Jorge C. Escalante‐Semerena   +2 more
wiley   +1 more source

Aminoglycoside phosphotransferases proteins structure and mechanism [PDF]

Frontiers in Bioscience, 1999
Aminoglycoside antibiotics constitute an important class of clinically useful drugs which are imperiled by the emergence of resistant organisms. Aminoglycoside resistance in the clinics is primarily due to the presence of modifying enzymes which N-acetylate, O-adenylate or O-phosphorylate the antibiotics.
Wright, G. D., Thompson, Paul R
openaire   +3 more sources

CNGCs in Marchantia paleacea uncouple arbuscular mycorrhizal symbiosis and rhizoid development

New Phytologist, EarlyView.
Rhizoid growth and AM fungal infection are uncoupled. Summary In Marchantia paleacea, MpaDMI1‐dependent nuclear Ca2+ oscillations are essential for arbuscular mycorrhizal (AM) fungal colonisation, indicating that endosymbiosis‐mediated nuclear Ca2+ signalling is a conserved feature of land plant–AM symbiosis.
Anson Ho Ching Lam, Aisling Cooke, Jake Richardson, Myriam Charpentier   +3 more
wiley   +1 more source

Rice EMF3 Alleles Adjust Flower Opening Time to Enhance the Seed Setting Rate Under High Temperature Stress

Plant Biotechnology Journal, EarlyView.
ABSTRACT To safeguard global food security against rapid population growth and a warming world, the effective genetic improvement of cereals is imperative. Flower opening time (FOT) critically affects the seed setting rate. In this study, we identified a gene, EARLY‐MORNING FLOWERING 3 (EMF3), in which single‐nucleotide substitutions strongly modulate ...
Takuma Ishizaki, Yoichi Hashida, Hideyuki Hirabayashi, Kazuhiro Sasaki, Hiroki Tokunaga, Eliza Vie M. Simon‐Ada, Masataka Wakayama, Toshiyuki Takai, Hiroki Saito, Atsushi J. Nagano, Hitoshi Sakakibara, Mikiko Kojima, Yumiko Takebayashi, Sung‐Ryul Kim, Ryo Matsushima, Michael J. Thomson, Kazuhiko Sugimoto, Ken‐Ichiro Hibara, Tsutomu Ishimaru   +18 more
wiley   +1 more source

The Phosphotransferase System in Solventogenic Clostridia

Microbial Physiology, 2015
The acetone-butanol-ethanol fermentation employing solventogenic clostridia was a major industrial process during the 20th century, but declined for economic reasons. In recent times, interest in the process has been revived due to the perceived potential of butanol as a superior biofuel.
openaire   +2 more sources

Gene Editing of Nicotiana benthamiana Architecture for Space‐Efficient Production of Recombinant Proteins in Closed Environments

Plant Biotechnology Journal, EarlyView.
ABSTRACT Indoor vertical farming (VF) offers practical advantages for the cultivation of plant protein bio‐factories including plant uniformity, product consistency, water/nutrient recycling and production cycles on a year‐round basis. Much progress has been achieved toward the development of innovative systems for artificial lighting, automated ...
Béatrice Giroux, Kristina LeBreux, Louis Feyzeau, Marie‐Claire Goulet, Charles Goulet, Dominique Michaud   +5 more
wiley   +1 more source

Genome‐Wide Association Study Elucidates the Genetic Architecture of Manganese Tolerance in Brassica napus

Plant, Cell &Environment, EarlyView.
ABSTRACT Brassica napus (canola) is a significant contributor to the world's oil production and is cultivated across continents, yet acidic soils with aluminium (Al3+) and manganese (Mn2+) toxicities limit its production. The genetic determinants underlying natural variation for acidic soil tolerance in canola are unknown and need to be determined ...
Harsh Raman, Zetao Bai, Brett McVittie, Sourav Mukherjee, Hugh D. Goold, Yuanyuan Zhang, Nay Chi Khin, Yu Qiu, Nawar Shamaya, Shengyi Liu, Regine Delourme, Barry J. Pogson, Sureshkumar Balasubramanian, Rosy Raman   +13 more
wiley   +1 more source