Journal of Biological Chemistry, 1982 We have previously reported that glucose can be phosphorylated by phospho-HPr and two sugar-specific pairs of proteins of the Escherichia coli and Salmonella typhimurium phosphoenolpyruvate:glycose phosphotransferase system. Each of the sugar-specific complexes comprises two proteins, lipid, and divalent cation, and each is present in membranes ...
Pieter W. Postma +4 more
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Immunity, Inflammation and Disease, Volume 13, Issue 4, April 2025.In Pggt1b‐deficient macrophages, TLR4 may be in a highly activated state and can be activated by R848 or DAMPS, which strongly correlated with increased cytokine production, interferon‐γ production, augmented amide binding and transferase activity, and the activation of NF‐κB and/or Nlrp3 inflammasome pathways.
Shanshan Yu +4 more
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THE ACTION OF ANHYDROUS ACIDS ON ATP:CREATINE PHOSPHOTRANSFERASE [PDF]
, 1962 Florante A. Quiocho, Felix Friedberg
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Mg2+ Supplementation Mitigates Metabolic Deficits Associated With TRPM7 Disruption
Journal of Cellular Physiology, Volume 240, Issue 4, April 2025.ABSTRACT Transient receptor potential channel subfamily M member 7 (TRPM7) regulates cellular and systemic Mg2+ homeostasis through its channel domain and induces protein phosphorylation via its kinase domain. We recently found that mice with selective deletion of Trpm7 in β‐cells develop glucose intolerance and declines in insulin secretion, primarily
Severin Boulassel +11 more
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ADENOSINE 5′-TRIPHOSPHATE-ARGININE PHOSPHOTRANSFERASE FROM LOBSTER MUSCLE: PURIFICATION AND PROPERTIES [PDF]
, 1965 Richard Virden +2 more
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The Peptide PROTAC Modality: A New Strategy for Drug Discovery
MedComm, Volume 6, Issue 4, April 2025.Peptide PROTAC is a bifunctional molecule generally composed of a target protein binding peptide (TBP), a linker peptide (LP), an E3 ligase binding peptide (EBP), and a delivery‐enhancing peptide (DEP), which can bind to the target protein (P) and E3 ligase (E3), inducing P to be labeled with ubiquitin (Ub) and subsequently recognized and degraded by ...
Youmin Zhu, Yu Dai, Yuncai Tian
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KINETIC STUDIES OF THE REVERSE REACTION CATALYSED BY ADENOSINE TRIPHOSPHATE-CREATINE PHOSPHOTRANSFERASE. THE INHIBITION BY MAGNESIUM IONS AND ADENOSINE DIPHOSPHATE [PDF]
, 1965 JF Morrison, W.J. O’Sullivan
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α/β Hydrolases: Toward Unraveling Entangled Classification
Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 4, Page 855-870, April 2025.ABSTRACT α/β Hydrolase‐like enzymes form a large and functionally diverse superfamily of proteins. Despite retaining a conserved structural core consisting of an eight‐stranded, central β‐sheet flanked with six α‐helices, they display a modular architecture allowing them to perform a variety of functions, like esterases, lipases, peptidases, epoxidases,
Fatih Ozhelvaci, Kamil Steczkiewicz
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Kinetic studies of the activation of adenosine triphosphate-lombricine phosphotransferase by magnesium ions [PDF]
, 1964 T. J. Gaffney, W.J. O’Sullivan
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Dihydroartemisinin inhibits melanoma migration and metastasis by affecting angiogenesis
Phytotherapy Research, Volume 39, Issue 4, Page 1679-1693, April 2025.Abstract Tumor angiogenesis is critical for tumor metastasis by providing oxygen, nutrients, and metastatic pathways. As a potential anti‐angiogenic agent, Dihydroartemisinin (DHA) can effectively inhibit tumor metastasis. However, the mechanism how it regulates angiogenesis to affect tumor metastasis has not been fully clarified.
Zhaoxiang Li +8 more
wiley +1 more source