Results 81 to 90 of about 25,251 (292)
GABA-modulating bacteria of the human gut microbiota. [PDF]
, 2019 The gut microbiota affects many important host functions, including the immune response and the nervous system1. However, while substantial progress has been made in growing diverse microorganisms of the microbiota2, 23-65% of species residing in the ...
Clardy, Jon +18 more
core
Frontiers in Microbiology, 2018 Environments polluted by direct discharges of effluents from antibiotic manufacturing are important reservoirs for antibiotic resistance genes (ARGs), which could potentially be transferred to human pathogens.
Juan J. González-Plaza +5 more
doaj +1 more source
Identifcation of small molecule enzyme inhibitors as broad-spectrum anthelmintics [PDF]
, 2019 Targeting chokepoint enzymes in metabolic pathways has led to new drugs for cancers, autoimmune disorders and infectious diseases. This is also a cornerstone approach for discovery and development of anthelmintics against nematode and flatworm parasites.
Aroian, Raffi V. +10 more
core +2 more sources
The FEBS Journal, EarlyView.Using cryo‐EM combined with biochemical and genetic approaches, we mapped the interaction surface between NifL and NifA to gain insights into the regulation of nitrogen fixation genes in A. vinelandii. Our findings suggest that NifL, a homolog of histidine kinases lacking phosphorylation activity, evolved to act as a steric block of NifA activity ...
Marcelo Bueno Batista +6 more
wiley +1 more source
Self-Assembled Supramolecular Nanoparticles Improve the Cytotoxic Efficacy of CK2 Inhibitor THN7
Pharmaceuticals, 2018 Since the approval of imatinib in 2001, kinase inhibitors have revolutionized cancer therapies. Inside this family of phosphotransferases, casein kinase 2 (CK2) is of great interest and numerous scaffolds have been investigated to design CK2 inhibitors ...
Abdelhamid Nacereddine +9 more
doaj +1 more source
From the phosphoenolpyruvate phosphotransferase system (PTS) to selfish metabolism: a story retraced in Pseudomonas putida [PDF]
, 2014 Although DNA is the ultimate repository of biological information, deployment of its instructions is constrained by the metabolic and physiological status of the cell. To this end, bacteria have evolved intricate devices that connect exogenous signals (e.
Lorenzo, Víctor de +1 more
core +1 more source
The FEBS Journal, EarlyView.Expression of the LEA‐K peptide in E. coli BL21 (DE3) improved bacterial viability under acidic stress (pH4), suggesting a protective function. RNA‐sequencing of LEA‐K‐expressing vs. non‐expressing cells revealed 283 differentially expressed genes (DEGs). In silico docking linked LEA‐K to two‐component systems (TCS) proteins (Rcs, BtsS/R, and EnvZ/OmpR)
Khaled Metwally, Shinya Ikeno
wiley +1 more source
Frontiers in MicrobiologyZearalenone (ZEN), a mycotoxin produced by Fusarium species, is widely distributed and poses significant health risks to both animals and humans due to its toxic effects. In this study, a Priestia megaterium MF3, exhibiting high ZEN degradation capacity,
Di Meng +9 more
doaj +1 more source
Bacterial fitness for plant colonization is influenced by plant growth substrate
New Phytologist, EarlyView.Summary Despite advances in our understanding of bacterial plant colonization, the extent to which growth substrate influences the molecular mechanisms enabling bacteria to efficiently colonize plants remains poorly understood. To address this, we used randomly barcoded transposon mutagenesis sequencing (RB‐TnSeq) in Paraburkholderia graminis OAS925 ...
Marta Torres +6 more
wiley +1 more source
Frontiers in Microbiology, 2019 Metagenomic investigations have the potential to provide unprecedented insights into microbial ecologies, such as those relating to antimicrobial resistance (AMR).
Pablo Rovira +13 more
doaj +1 more source