Results 31 to 40 of about 4,150 (110)
The Mysterious World of Non‐Canonical Caps – What We Know and Why We Need New Sequencing Techniques
ChemBioChem, Volume 26, Issue 3, February 1, 2025.This review describes sophisticated methodologies such as LC–MS that enabled the identification of 5’ non‐canonical RNA caps and also surveys so far developed sequencing methods, evaluating their advantages and disadvantages. It emphasizes the need for developing new, reliable sequencing techniques to identify RNA types with non‐canonical caps enabling
Flaminia Mancini, Hana Cahova
wiley +1 more source
Neuronal Ceroid Lipofuscinosis—Concepts, Classification, and Avenues for Therapy
CNS Neuroscience &Therapeutics, Volume 31, Issue 2, February 2025.This review comprehensively examined the pathogenic genes associated with various NCL subtypes, elucidating their roles, clinical presentations, corresponding mouse models, and the advances in clinical study of potential therapeutics. In particular, we clarified the potential of novel microglial cell replacement therapies in NCLs, providing hope for ...
Yuheng Zhang +4 more
wiley +1 more source
Paradigms of convergent evolution in enzymes
The FEBS Journal, Volume 292, Issue 3, Page 537-555, February 2025.Some enzymes are able to catalyse the same reaction despite possessing different structures. Here, we used a combined strategy of analysing published literature and knowledge‐based computational resources to explore this. We conclude that multiple varieties of convergent functional evolution exist to date, but that it is necessary to investigate ...
Ioannis G. Riziotis +5 more
wiley +1 more source
Journal of Diabetes Research, Volume 2025, Issue 1, 2025.Background: Shikonin (SHK) possesses extensive pharmacological effects including antimicrobial and anti‐inflammatory properties for diabetic wound (DW), while its molecular mechanism remains to be clarified. In this study, we investigated the potential mechanisms of SHK in treating DW by combining network pharmacology and in vitro experiments. Methods:
Meng Tian +9 more
wiley +1 more source
The Biosynthesis of Capuramycin-type Antibiotics: Identification of the A-102395 Biosynthetic Gene Cluster, Mechanism of Self-Resistence, and Formation of Uridine-5\u27-Carboxamide [PDF]
, 2015 A-500359s, A-503083s, and A-102395 are capuramycin-type nucleoside antibiotics that were discovered using a screen to identify inhibitors of bacterial translocase I, an essential enzyme in peptidoglycan cell wall biosynthesis. Like the parent capuramycin,
Baba, Satoshi +15 more
core +2 more sources
Molecular Plant Pathology, Volume 25, Issue 11, November 2024.Lonsdalea populi CpxA/CpxR manipulates pathogenesis and stress response by influencing flagella formation and function, regulating the type III secretion system and modulating transcription of membrane protein‐coding gene yccA. Abstract Bacteria employ two‐component systems (TCSs) to rapidly sense and respond to their surroundings often and during ...
Ruirui Yang +5 more
wiley +1 more source
COMPARATIVE APPROACHES FOR PLANT GENOMES: UNRAVELING "INTRA" AND "INTER" SPECIES RELATIONSHIPS FROM PRELIMINARY GENE ANNOTATIONS [PDF]
, 2016 Comparative genomics studies the differences and similarities between different species, to transfer biological information from model organisms to newly sequenced genomes, and to understand the evolutionary forces that drive changes in genomic features ...
Ambrosino, Luca
core
Strategies for Detecting Aminoacylation and Aminoacyl‐tRNA Editing in vitro and in Cells
Israel Journal of Chemistry, Volume 64, Issue 8-9, September 2024.Abstract Aminoacyl‐tRNA synthetases (aaRSs) maintain translational fidelity by ensuring the formation of correct aminoacyl‐tRNA pairs. Numerous point mutations in human aaRSs have been linked to disease phenotypes. Structural studies of aaRSs from human pathogens encoding unique domains support these enzymes as potential candidates for therapeutics ...
Rylan R. Watkins +2 more
wiley +1 more source
New Phytologist, Volume 243, Issue 6, Page 2187-2200, September 2024.Summary The superior productivity of C4 plants is achieved via a metabolic C4 cycle which acts as a CO2 pump across mesophyll and bundle sheath (BS) cells and requires an additional input of energy in the form of ATP. The importance of chloroplast NADH dehydrogenase‐like complex (NDH) operating cyclic electron flow (CEF) around Photosystem I (PSI) for ...
Maria Ermakova +7 more
wiley +1 more source
New Phytologist, Volume 243, Issue 4, Page 1406-1423, August 2024.Summary The GOLDEN2‐LIKE (GLK) transcription factors act as a central regulatory node involved in both developmental processes and environmental responses. Marchantia polymorpha, a basal terrestrial plant with strategic evolutionary position, contains a single GLK representative that possesses an additional domain compared to spermatophytes.
Arihel Hernández‐Muñoz +5 more
wiley +1 more source