Results 41 to 50 of about 4,150 (110)

Structural analysis of neomycin B and kanamycin A binding Aminoglycosides Modifying Enzymes (AME) and bacterial ribosomal RNA

Molecular Informatics, Volume 43, Issue 7, July 2024.
Abstract Aminoglycosides are crucial antibiotics facing challenges from bacterial resistance. This study addresses the importance of aminoglycoside modifying enzymes in the context of escalating resistance. Drawing upon over two decades of structural data in the Protein Data Bank, we focused on two key antibiotics, neomycin B and kanamycin A, to ...
Julia Revillo Imbernon, Jean‐Marc Weibel, Eric Ennifar, Gilles Prévost, Esther Kellenberger   +4 more
wiley   +1 more source

Reshaping Phosphatase Substrate Preference for Controlled Biosynthesis Using a “Design–Build–Test–Learn” Framework

Advanced Science, Volume 11, Issue 22, June 12, 2024.
A design–build–test–learn (DBTL) framework for rational enzyme design is proposed to modify the substrate preference of the phosphatase BT4131. The best mutant, exhibiting significantly enhanced preference for N‐acetylglucosamine‐6‐phosphate (GlcNAc6P), is combined with a GlcNAc6P biosensor and applied to microbial cell factories, resulting in a ...
Jiangong Lu, Xueqin Lv, Wenwen Yu, Jianing Zhang, Jianxing Lu, Yanfeng Liu, Jianghua Li, Guocheng Du, Jian Chen, Long Liu   +9 more
wiley   +1 more source

Critical appraisal of the SIBO hypothesis and breath testing: A clinical practice update endorsed by the European society of neurogastroenterology and motility (ESNM) and the American neurogastroenterology and motility society (ANMS)

Neurogastroenterology &Motility, Volume 36, Issue 6, June 2024.
Abstract Background There is compelling evidence that microbe‐host interactions in the intestinal tract underlie many human disorders, including disorders of gut‐brain interactions (previously termed functional bowel disorders), such as irritable bowel syndrome (IBS).
Purna Kashyap, Paul Moayyedi, Eamonn M. M. Quigley, Magnus Simren, Stephen Vanner   +4 more
wiley   +1 more source

Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a model for the complete yeast KEOPS complex. [PDF]

, 2015
International audienceThe yeast KEOPS protein complex comprising Kae1, Bud32, Cgi121, Pcc1 and Gon7 is responsible for the essential tRNA threonylcarbamoyladenosine (t(6)A) modification.
Collinet, Bruno, Daugeron, Marie-Claire, Durand, Dominique, Graille, Marc, Lazar, Noureddine, Libri, Domenico, van Tilbeurgh, Herman, Zhang, Wenhua   +7 more
core   +4 more sources

Inflammatory Microenvironment‐Responsive Hydrogels Enclosed with Quorum Sensing Inhibitor for Treating Post‐Traumatic Osteomyelitis

Advanced Science, Volume 11, Issue 20, May 28, 2024.
Inflammatory microenvironment targeted hydrogel promotes osteogenesis and inhibits inflammation in post‐traumatic osteomyelitis by responding to severe oxidative stress or acid abscess environment, and subsequently releasing quorum sensing inhibitors. It can inhibit “bacteria‐to‐bacteria communication” to clear planktonic bacteria and biofilms, reduce ...
Wenting Zhang, Huidan Lu, Wanying Zhang, Jiahao Hu, Yifei Zeng, Huiqun Hu, Liyun Shi, Jingyan Xia, Feng Xu   +8 more
wiley   +1 more source

Elm1p, a protein kinase that regulates cell morphology in Saccharomyces cerevisiae [PDF]

, 1995
Saccharomyces cerevisiae is a pleimorphic ascomycete, capable of growing in the yeast form or the pseudohyphal form. The pseudohyphal form is characterized by elongated cells that possess a unipolar budding pattern and grow in chains away from the center
Koehler, Carla Marie
core   +3 more sources

Glycomimicry: Display of the GM3 sugar epitope on Escherichia coli and Salmonella enterica sv Typhimurium [PDF]

, 2017
Oligosaccharides present on the surface of pathogenic bacteria play an important role in their interaction with their host. Bacteria with altered cell surface structures can be used to study these interactions, and glycoengineering represents a tool to ...
Aebi, Markus, Ilg, Karin, Maffioli, Carola, Priem, Bernard, Yavuz, Elif   +4 more
core  

Reticular dysgenesis-associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress. [PDF]

, 2015
Adenylate kinases (AKs) are phosphotransferases that regulate the cellular adenine nucleotide composition and play a critical role in the energy homeostasis of all tissues.
Al-Zahrani, Alberto Rissone, Alex DeVine, Aloj, Antoine, Argenton, Axel Schambach, Bandlow, Bertrand, Bertrand, Bujan, Burkart, Castaigne, Chen, Choi, Craven, Daily, De Vaal, Dzeja, Dzeja, Dzeja, Elisa Giocaliere, Fabio Candotti, Finckbeiner, Fischer, Flicek, Fujisawa, Giancarlo la Marca, Goujon, Hatefi, Henderson, Jang, Janssen, Jayashree Jagadeesh, Karen Lyn Simon, Katja Gabriele Weinacht, Kerry Dobbs, Kerstin Felgentreff, Kevin Bishop, Kimmel, Kissa, Köhler, Lagresle-Peyrou, Lagresle-Peyrou, Lawson, Le Guyader, Lee, Lee, Liesa, Lin, Liu, Luigi D. Notarangelo, Martha Kirby, Marypat Jones, Mugoni, Pannicke, Park, Park, Poliani, Pucar, Pucar, Raman Sood, Renaud, Rissone, Ryter, Sauer, Settara Chandrasekharappa, Shapiro, Sheehan, Single, Sood, Sood, Stephen Wincovitch, Takubo, Thisse, Thorsten Schlaeger, Traver, Waleed Al-Herz, Warlich, Westerfield, Whitford, Yuval Itan   +81 more
core   +4 more sources

Investigations of the PPi-dependent Acetate Kinase from the Parasite \u3ci\u3eEntamoeba histolytica\u3c/i\u3e [PDF]

, 2011
Acetate, a short-chain fatty acid that plays a key role in all domains of life, can be utilized as a carbon source or excreted as a product of metabolism.
Fowler, Matthew
core   +1 more source

Acetate Metabolism: The physiological role of ADP-forming acetyl-CoA synthetase and acetate kinase in Entamoeba histolytica [PDF]

, 2017
Entamoeba histolytica is a protozoan parasite that causes amoebic colitis and liver abscess in approximately 90 million people each year, resulting in 50,000-100,000 fatalities.
Dang, Thanh
core   +1 more source