Results 31 to 40 of about 12,039 (229)

Extracellular high mobility group box 1 as a UV-induced alarmin driving cutaneous inflammation and photoaging via TLR4 signaling. [PDF]

J Cell Commun Signal
UV irradiation triggers the active release of HMGB1 from skin cell nuclei into the extracellular space. Extracellular HMGB1 binds TLR4 receptors on neighboring cells, initiating a signaling cascade that upregulates proinflammatory cytokines (IL‐1β, IL‐6, IL‐8, and TNF‐α). This chronic inflammatory state drives neutrophil infiltration and collagen fiber
Liufu Q, Qin Z, Yan Y, Xu Y, He T, Liu Y, Xiang Y, Guo C, Quan T.   +8 more
europepmc   +2 more sources

Effects of reactive oxygen species on skin photoaging [PDF]

, 2016
The large surface area of the skin, high metabolism and location at the border of two environments (external and internal) cause continuous production of free radicals within the skin. There are two mechanisms of skin photoaging.
Ewelina Bartnicka, Anna M. Augustyniak, Helena Rotsztejn, Elżbieta Budzisz   +3 more
core   +1 more source

Therapeutic effect of concentrated growth factor preparation on skin photoaging in a mouse model

Journal of International Medical Research, 2020
Objective To establish a nude mouse model of photoaging and study the therapeutic effect of a concentrated growth factor preparation (CGF) on skin photoaging. Methods CGF was prepared from blood from Sprague–Dawley rats.
Rongrong Zhou, Miao Wang, Xudong Zhang, Aifen Chen, Yanghonghong Fei, Qiming Zhao, Danjing Guo, Hui Chen, Shusen Zheng   +8 more
doaj   +1 more source

New local treatment for photoaging using a formulation containing piroxicam 0.8% and sunscreen

Journal of International Medical Research, 2019
Objective Skin aging is a complex process influenced by several factors that cause DNA damage and alter the extracellular matrix. The anti-inflammatory drug piroxicam can counteract photocarcinogenesis and photoaging by blocking cyclooxygenases-1 and 2 ...
Mauro Mazzeo, Laura Diluvio, Monia Di Prete, Sara Mazzilli, Virginia Garofalo, Filadelfo Coniglione, Augusto Orlandi, Luca Bianchi, Elena Campione   +8 more
doaj   +1 more source

Alterations in extracellular matrix composition during aging and photoaging of the skin

Matrix Biology Plus, 2020
Human skin is composed of the cell-rich epidermis, the extracellular matrix (ECM) rich dermis, and the hypodermis. Within the dermis, a dense network of ECM proteins provides structural support to the skin and regulates a wide variety of signaling ...
Maxwell C. McCabe, Ryan C. Hill, Kenneth Calderone, Yilei Cui, Yan Yan, Taihao Quan, Gary J. Fisher, Kirk C. Hansen   +7 more
doaj   +1 more source

Multi-omics analysis of an in vitro photoaging model and protective effect of umbilical cord mesenchymal stem cell-conditioned medium

Stem Cell Research & Therapy, 2022
Background Skin ageing caused by long-term ultraviolet (UV) irradiation is a complex biological process that involves multiple signalling pathways. Stem cell-conditioned media is believed to have anti-ageing effects on the skin. The purpose of this study
Xiaocang Zou, Dayang Zou, Linhao Li, Renfeng Yu, XianHuang Li, Xingyue Du, JinPeng Guo, KeHui Wang, Wei Liu   +8 more
doaj   +1 more source

Analysis of the expression profile of miRNAs related to skin photoaging in the GEO database

Chinese Journal of Plastic and Reconstructive Surgery, 2023
Background: Skin aging has recently gained significant attention in both society and skin care research. Understanding the biological processes of photoaging caused by long-term skin exposure to ultraviolet radiation is critical for preventing and ...
KaHo LUI, Haibo Zhao, Jiaqi Sun, Zeren Shen, Jinghong Xu   +4 more
doaj   +1 more source

Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging

Cell & Bioscience, 2023
Background Ultraviolet A (UVA) irradiation can lead to skin damage and premature skin aging known as photoaging. This work found that UVA irradiation caused an imbalance between dermal matrix synthesis and degradation through the aberrant upregulation of
Yinan Li, Xiu Huang, Jing Jin, Haohao Zhang, Kai Yang, Jingxia Han, Ying Lv, Yu Sun, Cheng Yao, Tingting Lin, Caibin Zhu, Huijuan Liu   +11 more
doaj   +1 more source

Photoaging

American Journal of Clinical Dermatology, 2010
A rapidly increasing number of people visit dermatologists for the prevention and treatment of aging skin. Sun avoidance and sunscreen use are widely accepted strategies of primary prevention against photoaging. Convincing evidence shows that topical application of retinoids has an effect on reversing, at least partially, mild to moderate photodamage ...
Antoniou, C., Kosmadaki, M.G., Stratigos, A.J., Katsambas, A.D.   +3 more
openaire   +3 more sources

Aging Versus Photoaging: Postulated Mechanisms and Effectors [PDF]

, 1998
The differences between intrinsic aging and photoaging are reviewed. The various model systems currently employed for the studies of aging and photoaging are discussed.
Yaar, Mina, Gilchrest, Barbara A.
core   +1 more source