Drug-Induced Photosensitivity: Clinical Types of Phototoxicity and Photoallergy and Pathogenetic Mechanisms [PDF]
Frontiers in Allergy, 2022 Drug-induced photosensitivity (DIP) is a common cutaneous adverse drug reaction, resulting from the interaction of ultraviolet radiations, mostly ultraviolet A, with drugs. DIP includes phototoxicity and photoallergy.
Luca Di Bartolomeo +10 more
doaj +5 more sources
Photoallergy to Naproxen. [PDF]
Cureus, 2021 Reactions caused by photosensitivity, also called photodermatosis, are cutaneous reactions induced or exacerbated by exposure to electromagnetic radiation, including UV radiation, visible light, and infrared radiation.
Rojas Perez-Ezquerra P +4 more
europepmc +4 more sources
Innovative Strategies for Photoallergy Assessment: Breaking Free from Animal Models in Cosmetic Ingredient Development [PDF]
CosmeticsPhotoallergy, a unique form of skin sensitization induced by specific compounds under ultraviolet irradiation, has traditionally been investigated using animals.
Adriana Solange Maddaleno +2 more
doaj +3 more sources
Topical minocycline foam 4%: Results of four phase 1 studies evaluating the potential for phototoxicity, photoallergy, sensitization, and cumulative irritation [PDF]
Journal of Immunotoxicology, 2019 FMX101 4% contains 4% micronized minocycline (as an HCl) formulated in a lipophilic foam vehicle for topical administration. FMX101 4% has been shown to be an effective and well-tolerated treatment for moderate-to-severe acne in three Phase 3 pivotal ...
Jonathan Dosik +2 more
doaj +3 more sources
Pterin-lysine photoadduct: a potential candidate for photoallergy [PDF]
Photochemical and Photobiological Sciences, 2022 Photoallergy is a photosensitivity disorder associated with a modified ability of the skin to react to the combined effect of drugs and sunlight. It has been attributed to the covalent conjugation of proteins with a photosensitizer, yielding modified ...
Jesuán J. Farías +4 more
openalex +2 more sources
Contact Sensitization and Phototoxic and Photoallergic Potential of Tirbanibulin 1% Ointment in Healthy Volunteers [PDF]
JID Innovations, 2023 Tirbanibulin 1% ointment is approved for the topical treatment of actinic keratosis, applied once daily for 5 days. Three phase 1 randomized, single-center, controlled, within-subject comparison studies were conducted to evaluate the sensitization (KX01 ...
Jonathan Dosik +3 more
doaj +2 more sources
Drug-Induced Photosensitivity—From Light and Chemistry to Biological Reactions and Clinical Symptoms [PDF]
Pharmaceuticals, 2021 Photosensitivity is one of the most common cutaneous adverse drug reactions. There are two types of drug-induced photosensitivity: photoallergy and phototoxicity. Currently, the number of photosensitization cases is constantly increasing due to excessive
Justyna Kowalska +3 more
doaj +2 more sources
, 2018 Drugs are one of the representative exogenous agents that cause photosensitive dermatitis. Both phototoxic and photoallergic mechanisms exist in photosensitivity to exogenous agents.
Y. Tokura
openalex +2 more sources
Photosensitivity Reactions Induced by Photochemical Degradation of Drugs [PDF]
Advanced Pharmaceutical Bulletin, 2022 Photochemical degradation of drugs can lead to degradation products with potential toxic or allergizing effects for the human body. A significant amount of work has been carried out over the past few decades to clarify the molecular mechanism of ...
Hajnal Klelemen +3 more
doaj +2 more sources
PhotoChem Reference Chemical Database for the Development of New Alternative Photosafety Test Methods [PDF]
ToxicsPhotosafety assessments are a key requirement for the safe development of pharmaceuticals, cosmetics, and agrochemicals. Although in vitro methods are widely used for phototoxicity and photoallergy testing, their limited applicability and predictive ...
Ga-Young Lee +4 more
doaj +2 more sources