Results 1 to 10 of about 4,861 (168)

Pemafibrate prevents choroidal neovascularization in a mouse model of neovascular age-related macular degeneration [PDF]

PeerJ, 2023
Background Pathological choroidal neovascularization (CNV) is one of the major causes of visual impairment in neovascular age-related macular degeneration (AMD).
Deokho Lee, Ayaka Nakai, Yukihiro Miwa, Kazuno Negishi, Yohei Tomita, Toshihide Kurihara   +5 more
doaj   +2 more sources

Retinal dysfunction induced in a mouse model of unilateral common carotid artery occlusion [PDF]

PeerJ, 2021
Background Retinal ischemic stresses are associated with the pathogenesis of various retinal vascular diseases. To investigate pathological mechanisms of retinal ischemia, reproducible, robust and clinically significant experimental rodent models are ...
Deokho Lee, Heonuk Jeong, Yukihiro Miwa, Ari Shinojima, Yusaku Katada, Kazuo Tsubota, Toshihide Kurihara   +6 more
doaj   +2 more sources

Modulation of Hypoxia-Inducible Factors and Vascular Endothelial Growth Factor Expressions by Superfood Camu-Camu (Myrciaria dubia) Treatment in ARPE-19 and Fetal Human RPE Cells

Journal of Ophthalmology, 2023
Background. Anti-vascular endothelial growth factor (anti-VEGF) therapy via intravitreal injection is an effective treatment for patients with abnormal ocular neovascularization, such as age-related macular degeneration (AMD) and diabetic macular edema ...
Ayaka Nakai, Deokho Lee, Chiho Shoda, Kazuno Negishi, Hiroyuki Nakashizuka, Satoru Yamagami, Toshihide Kurihara   +6 more
doaj   +1 more source

Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes

Nature Communications, 2022
he underlying mechanism of myopic axial elongation of the eyes has long been unknown. Here, the authors show that endoplasmic reticulum stress in the sclera and its sensor proteins, PERK and ATF6, are involved in myopic axial ...
Shin-ichi Ikeda, Toshihide Kurihara, Xiaoyan Jiang, Yukihiro Miwa, Deokho Lee, Naho Serizawa, Heonuk Jeong, Kiwako Mori, Yusaku Katada, Hiromitsu Kunimi, Nobuhiro Ozawa, Chiho Shoda, Mari Ibuki, Kazuno Negishi, Hidemasa Torii, Kazuo Tsubota   +15 more
doaj   +1 more source

Spectral effects on Symbiodinium photobiology studied with a programmable light engine. [PDF]

PLoS ONE, 2014
The spectral light field of Symbiodinium within the tissue of the coral animal host can deviate strongly from the ambient light field on a coral reef and that of artificial light sources used in lab studies on coral photobiology.
Daniel Wangpraseurt, Bojan Tamburic, Milán Szabó, David Suggett, Peter J Ralph, Michael Kühl   +5 more
doaj   +1 more source

Photobiological hydrogen as a renewable fuel [PDF]

The Holistic Approach to Environment, 2021
The huge global energy consumption has raised concerns over the depletion in readily available conventional energy resources. Besides, there are harmful atmospheric effects of fossil fuels and the qualms of future energy resources.
Vidya Jose
doaj   +1 more source

Establishment of a novel ER-stress induced myopia model in mice

Eye and Vision, 2023
Background Recent studies have indicated a strong correlation between endoplasmic reticulum (ER) stress and myopia and that eyedrops containing the ER stress inducer tunicamycin (Tm) can induce myopic changes in C57BL/6 J mice.
Longdan Kang, Shin-ichi Ikeda, Yajing Yang, Heonuk Jeong, Junhan Chen, Yan Zhang, Kazuno Negishi, Kazuo Tsubota, Toshihide Kurihara   +8 more
doaj   +1 more source

Fenofibrate Protects against Retinal Dysfunction in a Murine Model of Common Carotid Artery Occlusion-Induced Ocular Ischemia

Pharmaceuticals, 2021
Ocular ischemia is a common cause of blindness and plays a detrimental role in various diseases such as diabetic retinopathy, occlusion of central retinal arteries, and ocular ischemic syndrome. Abnormalities of neuronal activities in the eye occur under
Deokho Lee, Yohei Tomita, Yukihiro Miwa, Heonuk Jeong, Kiwako Mori, Kazuo Tsubota, Toshihide Kurihara   +6 more
doaj   +1 more source

Structural insights into photosystem II supercomplex and trimeric FCP antennae of a centric diatom Cyclotella meneghiniana

Nature Communications, 2023
Diatoms are dominant marine algae and contribute around a quarter of global primary productivity, the success of which is largely attributed to their photosynthetic capacity aided by specific fucoxanthin chlorophyll-binding proteins (FCPs) to enhance the
Songhao Zhao, Lili Shen, Xiaoyi Li, Qiushuang Tao, Zhenhua Li, Caizhe Xu, Cuicui Zhou, Yanyan Yang, Min Sang, Guangye Han, Long-Jiang Yu, Tingyun Kuang, Jian-Ren Shen, Wenda Wang   +13 more
doaj   +1 more source

Photochemical and Photobiological Activity of Zn, Cu, Ni, Co, Fe and Mn Unsubstituted Phthalocyanines

Chemistry Proceedings, 2023
Phthalocyanines are a group of porphyrin synthetic molecules. These compounds show outstanding photodynamic properties. This is due to their high ability to photogenerate free radicals, such as 1O2 and O.−2.
Franklin Vargas, Miguel León, Álvaro Álvarez, Sergio Dasilva, Alexis Maldonado   +4 more
doaj   +1 more source