Results 51 to 60 of about 25,848 (226)

Tyrosine/Cysteine Cluster Sensitizing Human γD-Crystallin to Ultraviolet Radiation-Induced Photoaggregation in Vitro [PDF]

open access: yes, 2013
Ultraviolet radiation (UVR) exposure is a major risk factor for age-related cataract, a protein-aggregation disease of the human lens often involving the major proteins of the lens, the crystallins.
King, Jonathan Alan   +3 more
core   +1 more source

Single‐Cell Metabolic Imaging and Digital Scoring of Fat Tissue Remodeling by Label‐Free Metabolic Microscopy

open access: yesAdvanced Science, EarlyView.
Mid‐infrared optoacoustic microscopy (MiROM) acquires lipid‐ and protein‐ associated vibrational contrast in intact fat tissue without dyes, preserving native tissue architecture. Through lateral and axial segmentation, MiROM tracks intrinsic intracellular changes during postnatal remodeling. A quantitative spatial analysis tool (Q‐SAT) maps white‐ and
Myeongseop Kim   +7 more
wiley   +1 more source

Second harmonic generating (SHG) nanoprobes: a new tool for biomedical imaging [PDF]

open access: yes, 2009
Fluorescence microscopy has profoundly changed how cell and molecular biology is studied in almost every aspect. However, the need of characterizing biological targets is largely unmet due to deficiencies associated with the use of fluorescent agents ...
Fraser, Scott   +3 more
core   +1 more source

Liposomal Nanoconfinement Enables Type I Photodynamic Conversion for Synergistic Cancer Photothermal‐Immunotherapy

open access: yesAdvanced Science, EarlyView.
Liposomal nanoconfinement converts the hemicyanine photosensitizer RhM from Type‐II to Type‐I photodynamic therapy (PDT) while enhancing photothermal therapy (PTT). The RhM‐R837@Lip nanoassembly efficiently generates superoxide (O2•−) and hydroxyl radicals (•OH) to kill tumor cells and achieve tumor ablation.
Minglu Zhang   +14 more
wiley   +1 more source

Elevated Inorganic Carbon Concentrating Mechanism Confers Tolerance to High Light in an Arctic Chlorella sp. ArM0029B

open access: yesFrontiers in Plant Science, 2018
Microalgae and higher plants employ an inorganic carbon (Ci) concentrating mechanism (CCM) to increase CO2 availability to Rubisco. Operation of the CCM should enhance the activity of the Calvin cycle, which could act as an electron sink for electrons ...
Kwon Hwangbo   +6 more
doaj   +1 more source

Deep and fast live imaging with two-photon scanned light-sheet microscopy [PDF]

open access: yes, 2011
We implemented two-photon scanned light-sheet microscopy, combining nonlinear excitation with orthogonal illumination of light-sheet microscopy, and showed its excellent performance for in vivo, cellular-resolution, three-dimensional imaging of large ...
A Edelstein   +30 more
core   +3 more sources

Disulfide‐Bridged Ru Complex–Mediated Photo‐Disulfidptosis for Colorectal Cancer Therapy

open access: yesAdvanced Science, EarlyView.
In this work, a binuclear ruthenium complex, RuSSRu was developed for efficient colorectal cancer (CRC) treatment. The synergistic interaction between disulfidptosis and lysosomal damage‐induced apoptosis induced by RuSSRu amplified tumor cell death. This innovative approach offers a potent therapeutic strategy for CRC.
Simeng He   +8 more
wiley   +1 more source

Oral Photoprotection: Effective Agents and Potential Candidates

open access: yesFrontiers in Medicine, 2018
Electromagnetic radiation in the ultraviolet, visible, and infrared ranges produces biologic effects in humans. Where some of these effects are beneficial, others are harmful to the skin, particularly those stemming from ultraviolet radiation (UVR ...
Concepción Parrado   +5 more
doaj   +1 more source

Realignment-enhanced coherent anti-Stokes Raman scattering (CARS) and three-dimensional imaging in anisotropic fluids

open access: yes, 2008
We apply coherent anti-Stokes Raman Scattering (CARS) microscopy to characterize director structures in liquid crystals.Comment: 14 pages, 11 ...
Aliaksandr V. Kachynski   +43 more
core   +1 more source

High‐Content SRS Imaging Unveils Altered Cholesterol Metabolism in Ovarian Cancers Under CAR‐T Treatment

open access: yesAdvanced Science, EarlyView.
High‐content Stimulated Raman Scattering (SRS) Imaging reveals that ovarian cancer cells surviving Chimeric Antigen Receptor (CAR) ‐T cell challenge exhibit increased cholesterol esterification. Pharmacological inhibition of this pathway with Avasimibe significantly enhances CAR‐T induced killing of ovarian cancer cells by reducing cancer cell ...
Chinmayee V. Prabhu Dessai   +8 more
wiley   +1 more source

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