Results 151 to 160 of about 138,197 (278)

A Spatiotemporally Controlled Nanoplatform for Photothermal BRD4 Degradation Enables Synergistic Cancer Immunotherapy

Advanced Science, EarlyView.
A GSH‐responsive MOF nanoplatform acts as a Photothermolysis‐Targeting Conjugate (PTTAC). Through sophisticated step‐wise nuclear delivery, it enables NIR‐II light‐triggered photothermal degradation of BRD4. This precise strategy induces robust immunogenic cell death (ICD) and powerfully synergizes with anti‐PD‐L1 blockade to elicit a potent systemic ...
Luyi Wang, Jiasha Wu, Rui Ji, Sufeng Qiang, Yulin Shen, Yan Zuo, Shiqin Jian, Siyao Liu, Fusheng Xu, Honggang Hu, Xiaochun Hu   +10 more
wiley   +1 more source

Defect‐Rich 2D Layered Double Hydroxides Enhance Sonodynamic Antibacterial Therapy

Advanced Science, EarlyView.
This study develops defect‐rich ultrathin ZnCuW‐LDH nanosheets (DR‐ZnCuW‐LDH) via acid etching. DR‐ZnCuW‐LDH exhibits fourfold enhanced US‐triggered ROS production due to oxygen defects and electronic modulation, demonstrating potent antibacterial efficacy in vitro/vivo.
Qian Liu, Yu Yang, Rui Zhao, Linwei Huang, Xingyu Qi, Min Wu, Jianliang Shen   +6 more
wiley   +1 more source

A LDH‐Based Supramolecular Photosensitizer‐Functionalized Bioactive Glass Scaffold for Integrated Postoperative Osteosarcoma Recurrence Prevention and Bone Regeneration

Advanced Science, EarlyView.
An intercalation assembly strategy is proposed to construct a novel LDH‐based supramolecular photosensitizer, which exhibits outstanding reactive oxygen species generation activity under 1270 nm laser irradiation. The deposition of supramolecular photosensitizer onto the surface of bioactive glass scaffolds results in the development of an innovative ...
Tao Wang, Yixin Bian, Tingting Hu, Mengyang Li, Yuqin Tan, Yu Yang, Xiaolan Jian, Xisheng Weng, Chaoliang Tan, Ruizheng Liang   +9 more
wiley   +1 more source

Microalgae as a Source of Photosensitizers: Analytical Strategies and Biomedical Use in Photodynamic Therapy. [PDF]

Pharmaceuticals (Basel)
Kuanyshbay A, Iskakova Z, Aibuldinov Y, Kolpek A, Tashenov Y, Tursynova N, Tekebayeva Z, Rakhymzhan Z, Temirbekova A, Kulzhanova K, Zhantokov B, Bazarkhankyzy A.   +11 more
europepmc   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

A Noncovalent Click‐to‐Release Strategy to Control Bond Cleavage and Prodrug Activation

Angewandte Chemie, EarlyView.
Extending the click‐to‐release concept beyond covalent ligation, we introduce a noncovalent click‐to‐release strategy based on cucurbituril‐adamantane (CB‐Ad) association. A supramolecular preassembly encapsulating a self‐immolative guest (SIG) is rationally designed to prevent premature release, while adding a high‐affinity Ad guest initiates the CB ...
Xuancheng Fu, Bowen Xu, Suman Maity, Michelle Wu, Luke G. Westbrook, James H. Henderson, Yaoying Wu, Katie A. Edwards, Atanu Acharya, Xiaoran Hu   +9 more
wiley   +2 more sources

Comparision of the efficacy of photodynamic therapy and imiquimod cream in patients with actinic keratosis: a systematic review and meta-analysis. [PDF]

Sci Rep
Tian Y, Yao Y, Zhang J.
europepmc   +1 more source

Rod‐Like PLGA Microrobots with Enhanced Motion and Biodegradation for Magnetic‐Guided Drug Delivery

Advanced Intelligent Systems, EarlyView.
This study presents drug‐loaded Poly (lactic‐co‐glycolic acid) (PLGA) microrobots fabricated from an oil‐in‐water (O/W) emulsion of PLGA, Fe3O4 nanoparticles, and Adriamycin (DOX). They are formed by film‐forming and stretching microrobots, and exhibit motion analyzed via video‐snapshots, speed graphs, and shape changes, advancing targeted for drug ...
Junkai Zhang, Yukun Zhong, Zihao Chu, Xinran Geng, Zerui Li, Hongxi Yin, U Kei Cheang   +6 more
wiley   +1 more source

Stereospecific Assembly of Triply Chiral Pseudopeptidic Cages Through Dynamic Dual Chirality Transfer

Angewandte Chemie, EarlyView.
The spontaneous assembly of triply chiral (L, Δ, P or D, Λ, M) cages has been achieved from a simple tripodal chiral effector based on phenylalanine tris(amidoamine), non‐chiral bipyridine dialdehyde, and a metal ion. Orthogonal imine bond and iron (II) coordination generate a single combination of chiral elements, while configurationally stable ...
Tushar D. Bhosale, Eudald Usan, Delia Miguel, Jordi Solà, Angel Orte, Ciril Jimeno, Ignacio Alfonso   +6 more
wiley   +2 more sources

Micro/Nanorobot for Drug Delivery—A Review of Material Selections

Advanced NanoBiomed Research, EarlyView.
This review explores material strategies for biomedical micro/nanorobots, emphasizing their roles in propulsion, navigation, drug delivery, and biodegradability. It highlights advancements in metallic, polymeric, and hybrid materials, while addressing clinical translation challenges such as toxicity, immune response, and manufacturability.
Xiaozhuo Wu, Bingyun Li, Malcolm Xing
wiley   +1 more source