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Photodynamic therapy in oncology
Expert Opinion on Pharmacotherapy, 2001Photodynamic therapy (PDT) is a cancer treatment modality that is based on the administration of a photosensitiser, which is retained in tumour tissues more than in normal tissues, followed by illumination of the tumour with visible light in a wavelength range matching the absorption spectrum of the photosensitiser.
C H, Sibata +3 more
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Photodynamic therapy: An update
Clinical Oncology, 1994The cytotoxic potential of photosensitisers has been known for more than half a century, but it is only in the last decade or so that it has been studied in much greater depth and evaluated critically in both laboratory and clinical settings. Photodynamic therapy (PDT) usually involves the systemic administration of a photosensitiser which is retained ...
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Photodynamic therapy for mesothelioma
Current Treatment Options in Oncology, 2001Multiple trials of traditional cancer therapies for malignant pleural mesothelioma (including surgery, radiation therapy, and chemotherapy) have not convincingly demonstrated that any one treatment is superior to supportive care alone. Although there have been reports of long-term survivors who were treated with aggressive surgery combined with ...
S M, Hahn, R P, Smith, J, Friedberg
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2019
Photodynamic therapy is a promising, minimally invasive, and clinically approved treatment strategy that destroys the cell components by oxidizing the biological molecules such as nucleic acids, carbohydrates, proteins, and lipids, and leads apoptosis in the cells of the target tissue through the generation of singlet oxygen and reactive oxygen species
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Photodynamic therapy is a promising, minimally invasive, and clinically approved treatment strategy that destroys the cell components by oxidizing the biological molecules such as nucleic acids, carbohydrates, proteins, and lipids, and leads apoptosis in the cells of the target tissue through the generation of singlet oxygen and reactive oxygen species
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Lasers in Surgery and Medicine, 2006
AbstractBackground and ObjectivesPhotodynamic therapy (PDT) is an emerging modality for the treatment of various neoplastic and non‐neoplastic pathologies.Study Design/Materials and MethodsPDT usually occurs when reactive oxygen species (ROS) generated from light‐activated chemicals (photosensitizer, PS) destroy the target.
Nicolas, Solban +2 more
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AbstractBackground and ObjectivesPhotodynamic therapy (PDT) is an emerging modality for the treatment of various neoplastic and non‐neoplastic pathologies.Study Design/Materials and MethodsPDT usually occurs when reactive oxygen species (ROS) generated from light‐activated chemicals (photosensitizer, PS) destroy the target.
Nicolas, Solban +2 more
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Photodynamic therapy in cholangiocarcinomas
Best Practice & Research Clinical Gastroenterology, 2004Symptoms occur late in cholangiocarcinoma and therefore only about half of the patients at the time of diagnosis are candidates for curative surgery. In patients with advanced non-resectable cholangiocarcinoma palliative treatment options are limited. Until now, insertion of endoprostheses for the treatment of cholestasis has been the method of choice.
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Photodynamic therapy for cancer
Nature Reviews Cancer, 2003The therapeutic properties of light have been known for thousands of years, but it was only in the last century that photodynamic therapy (PDT) was developed. At present, PDT is being tested in the clinic for use in oncology--to treat cancers of the head and neck, brain, lung, pancreas, intraperitoneal cavity, breast, prostate and skin.
Dennis E J G J, Dolmans +2 more
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Photodynamic therapy and cancer
BMJ, 2009Promising results need to be followed by development of more selective drugs Photodynamic therapy uses visible light, molecular oxygen (normally present in most tissues at adequate concentration), and an otherwise innocuous drug to destroy tumours.1 All three components are needed for the cytotoxic effect.
Brown, Stanley B., Ibbotson, Sally H.
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Intraperitoneal Photodynamic Therapy
2007Peritoneal carcinomatosis and sarcomatosis are generally incurable problems for which there are few good treatment options. Intraperitoneal PDT is potentially an ideal therapy for peritoneal carcinomatosis because of its relatively superficial treatment effect.
K A, Cengel, E, Glatstein, S M, Hahn
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Lasers in Photodynamic Therapy
Nursing Clinics of North America, 1990Photodynamic therapy has been shown to provide a reasonable alternative to other treatment modalities for patients with certain cancers, and in some cases may be the preferred treatment. Currently, photodynamic therapy is under FDA-approved clinical investigational trials in the treatment of tumors of the skin, bronchus, esophagus, bladder, head and ...
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