Results 61 to 70 of about 27,083 (265)

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

open access: yesAdvanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu   +11 more
wiley   +1 more source

Symbiotic Nova PU Vul - 33 Years of Observations

open access: yesOpen Astronomy, 2012
We present UBVRI light curves of the symbiotic nova PU Vul after its outburst in 1978. Three observed eclipses of the hot component by the cool one were used to determine the ephemeris of the binary system as JD (Min I) = 2444550(15) + 4897(10) × E days.
Shugarov S., Chochol D., Kolotilov E.
doaj   +1 more source

Combining Fret and Super‐Resolution Microscopy Reveals Kinase Activation and Mitochondrial Activity at the Nanoscale

open access: yesAdvanced Science, EarlyView.
BioSenSRRF is an open‐source workflow that combines conventional FRET biosensors with SRRF reconstruction to generate sub‐diffraction FRET index maps on standard microscopes. The pipeline integrates automated image registration, SRRF reconstruction, quantitative FRET index calculation, and random line‐based hotspot analysis to uncover AURKA‐dependent ...
Nicolas Y. Jolivet   +5 more
wiley   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

open access: yesAdvanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim   +4 more
wiley   +1 more source

Telescope and Researcher Potential of Turkey for Collaboration in CV Studies

open access: yesOpen Astronomy, 2012
Turkish astronomical community has witnessed the construction of several telescopes in the last 10 years. These telescopes and the potential of young researchers in the country motivated this poster presentation which aims to receive attention for ...
Saygac A. Talat, Alis Sinan
doaj   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

open access: yesAdvanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu   +14 more
wiley   +1 more source

Polarisation photometric stereo [PDF]

open access: yesComputer Vision and Image Understanding, 2017
This paper concerns a novel approach to fuse two-source photometric stereo (PS) data with polarisation information for complete surface normal recovery for smooth or slightly rough surfaces. PS is a well-established method but is limited in application by its need for three or more well-spaced and known illumination sources and Lambertian reflectance ...
openaire   +1 more source

Stellar Photometry at the Crossroads of the Two Centuries

open access: yesOpen Astronomy, 2003
In the last century photometry was recognized as a powerful method for investigation of physical parameters of stars and of interstellar matter. Photometric investigations now cover the spectral range from the far ultraviolet to the far infrared.
Straižys V.
doaj   +1 more source

Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils

open access: yesAdvanced Science, EarlyView.
We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr   +19 more
wiley   +1 more source

Interstellar Extinction in the Gaia Photometric Systems

open access: yesOpen Astronomy, 2003
Three medium-band photometric systems proposed for the Gaia space mission are intercompared in determining color excesses for stars of spectral classes from O to M at V = 18 mag.
Bridžius A., Vansevičius V.
doaj   +1 more source

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