Results 61 to 70 of about 64,417 (247)
α‐Synuclein Forms Distinct Micelle‐Like Assemblies at Low Ionic Strengths
Advanced Science, EarlyView.At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...Sophie Hertel, Soumik Ray, Federica Saraceno, Giacomo Nisini, Georgia Nasi, Thomas Oliver Mason, Antonin Kunka, Effrosyni Agrimaki, Dannie Juul Olesen, Francesco Simone Ruggeri, Alexander K. Buell +10 morewiley +1 more sourceNew Candidate Massive Clusters from 2MASS [PDF]
, 2013 Massive stars are important for the evolution of the interstellar medium. The detailed study of their properties (such as mass loss, rotation, magnetic fields) is enormously facilitated by samples of these objects in young massive galactic star clusters. Dirk Froebrich, Froebrich, Dirkcore +1 more sourcePossible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury
British Journal of Clinical Pharmacology, EarlyView.Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.Danilo Alves‐Bezerra, Luiza B. Negreiros, Amaury Pereira‐Acácio, Isadora G. Almeida, João P. M. Veloso‐Santos, Jarlene A. Lopes, Glória Costa‐Sarmento, Humberto Muzi‐Filho, Adalberto Vieyra +8 morewiley +1 more sourceTerms Photometry of Known Transiting Exoplanets [PDF]
, 2011 The Transit Ephemeris Refinement and Monitoring Survey conducts radial velocity and photometric monitoring of known exoplanets in order to refine planetary orbits and predictions of possible transit times. This effort is primarily directed toward planets Kane, Stephen R., Genady Pilyavsky, Wyatt, Pamela, Gelino, Dawn M., Jason T. Wright, Ciardi, David R., Pamela Wyatt, Diana Dragomir, Kaspar von Braun, Stephen R. Kane, Wright, Jason T., Payne, Alan, Dawn M. Gelino, Rabus, Markus, Ramirez, Solange V., Pilyavsky, Genady, Alan Payne, von Braun, Kaspar, J. Zachary Gazak, Suvrath Mahadevan, Dragomir, Diana, Mahadevan, Suvrath, Gazak, J. Zachary, Markus Rabus, Solange V. Ramirez, David R. Ciardi +25 morecore +1 more sourcePhotometric Observations and Light Curve Analysis of BL Eridani [PDF]
Journal of Astronomy and Space Sciences, 2006 We present light curves of a short period binary system BL Eridani. The light curves were observed with {it VRI} filters by a 50cm wide field robotic telescope at Siding Spring Observatory (SSO), equipped with a 2K CCD camera, which was developed by ...Wonyong Han, Hong-Suh Yim, Chung-Uk Lee, Jae-Hyuck Youn, Joh-Na Yoon, Ho-Il Kim, Hong-Kyu Moon, Yong-Ik Byun, Sunyoup Park +8 moredoaj +1 more sourceStatus and future of recombinant adeno‐associated virus vector manufacturing
Biotechnology Progress, EarlyView.Abstract
Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...Frank Agbogbo, David Dismukewiley +1 more sourceEstimating the parameters of globular cluster M 30 (NGC 7099) from time-series photometry [PDF]
, 2013 Aims. We present the analysis of 26 nights of V and I time-series observations from 2011 and 2012 of the globular cluster M 30 (NGC 7099). We used our data to search for variable stars in this cluster and refine the periods of known variables; we then ...M. T. Penny, Southworth, J., H. Kjeldsen, Southworth, J, Fang, X. S., Diehl C., Elyiv, Andrii, Kains, N, Vilela, C., Harpsøe, Kennet Bomann West, BOZZA, Valerio, Scarpetta G., J. M. Andersen, Southworth J., Bramich, D. M., MANCINI, Luigi, Korhonen, H., Dodds, Peter, Kerins, E.; id_orcid, Wertz, Olivier, Y. Damerdji, Williams, Andrew, Gu S. -H., Kains, N., Penny, Mt, Hornstrup A., Jørgensen, U.~G., J. Tregloan Reed, CALCHI NOVATI, Sebastiano, Giannini E., Ferro, A.A., Juncher D., Jørgensen, U., Williams, A., Andersen, J.M., Burgdorf M., Kjeldsen H., S.-H. Gu, Williams, A, Elyiv, A., Martin, R., Kjeldsen, H., Fang X. -S., Gu, S.-H., Bozza V., Harpsoe, K., A. Williams, O. Wertz, Damerdji, Yassine, Vilela, C, Liebig C., Diehl, Carl, S. H. Gu, Mathiasen, Merete Irene Lejsberg, Dodds P., Lundkvist, Mia, Giannini, E., Williams, Andrew Richard, Figuera Jaimes R., S. Giridhar, Burgdorf, M, J. Jessen-Hansen, Dodds, P., Juncher, D., J. Jessen Hansen, Hardis S., Damerdji, Y, R. Figuera Jaimes, Browne P., Calchi Novati, S., Ricci, Davide, Scarpetta, G., Browne, P., Skottfelt J., Lund, Mn, Kjeldsen, Hans, Hornstrup, Allan, Arellano Ferro A., E. Giannini, Gu, S. H., Liebig, C., Skottfelt, J, Jessen-Hansen, Jens, C. Vilela, C. Diehl, Scarpetta, G, D. Juncher, Martin R., Andersen, J.~M., Penny, M.~T., Ricci, D, Lundkvist M., Bramich, D.M., Hinse, T., Jaimes, R.F., Korhonen, Heidi Helena, Gu, S. -H., Rahvar, S, Damerdji, Y., Hundertmark, Markus Peter Gerhard, M. Dominik, Mathiasen M., Lund, M., Kjeldsen, Helle Møgelmose, Alsubai, K. A., Burgdorf, M., Rahvar, S., Rabus, M, Hinse T. C., N. Kains, Penny, M., Kjeldsen, H, Elyiv, A, Giridhar, S, (The MiNDSTEp consortium), Lundkvist, M., U. G. Jørgensen, Penny M. T., Lund M. N., Andersen, J., P. Dodds, S. Rahvar, Lund, M.N., Snodgrass, C, Penny, M.T., Calchi Novati, S, Lund, M. N., SCARPETTA, Gaetano, Kerins, E, Arellano Ferro, A., Figuera Jaimes, R, Liebig, C, R. Martin, Hornstrup, A, Sahu, K., Dodds, P, Hinse, T.C., Harpsoe K., Alsubai, K., Rabus M., D. M. Bramich, Gu, S., Gu, S-, Jorgensen, U. G., Novati, S., M. N. Lund, M. Rabus, J. Surdej, Harpsoe, K, Snodgrass C., Andersen J. M., Skottfelt, Jesper Mirsa, Bramich D. M., Mancini, L., Skottfelt, J., H. Korhonen, Ricci, D., P. Browne, Bramich, Dm, S. Hardis, J. Southworth, Wertz, O, Alsubai, K.A., Andersen, Jm, Fang, X.-S., Rabus, M., Bozza, V., Jessen-Hansen, J., M. Hundertmark, Vilela C., M. Lundkvist, Hundertmark M., Tregloan-Reed J., E. Kerins, A. Elyiv, Browne, Paul, Tregloan-Reed, J, Damerdji Y., A. Arellano Ferro, Korhonen H., Lundkvist, M, L. Mancini, G. Scarpetta, Fang, X., Alsubai, Ka, Fang, X-, Alsubai K. A., M. Mathiasen, D. Ricci, K. Sahu, Hundertmark, M, Sahu, K, Bramich, D.~M., Mathiasen, M., Jorgensen, Ug, Hinse, Tc, Arellano Ferro, A, Juncher, Dorte, Hardis, S, Hundertmark, M., J. Tregloan-Reed, V. Bozza, K. Harpsøe, Jessen-Hansen, J, Mathiasen, M, Surdej, J., A. Hornstrup, J. Skottfelt, Korhonen, H, Harpsøe, K., X.-S. Fang, S. Calchi Novati, Jessen-Hansen J., Jorgensen, U., Sahu K., M. Burgdorf, Jørgensen, Uffe Gråe, C. Snodgrass, K. A. Alsubai, Jørgensen, U.G., Wertz, O., Rahvar S., Williams A., Mancini, L, Tregloan-Reed, J., Fang, X. -S., Giridhar, S., T. C. Hinse, Wertz O., Kains N., The Consortium, M., Hornstrup, A., Jørgensen, U. G., Dominik, M., Hinse, T. C., Martin, R, Bozza, V, Dominik, M, Dominik, Martin, Snodgrass, C., C. Liebig, Figuera Jaimes, R., Penny, M. T., Hardis, S., Elyiv A., Surdej J., Giannini, E, Surdej, J, Ricci D., Lund, M.~N., Surdej, Jean, Andersen, J. M., Alsubai, K.~A., Kerins, E., Browne, P, Diehl, C, Kerins E., Hinse, T.~C.; id_orcid, Dominik M., Bramich, D., Jaimes, R., Jorgensen U. G., X. S. Fang, Calchi Novati S., Figuera Jaimes, Roberto Jose, Giridhar S., Juncher, D, Skottfelt, Jesper Fælling, Mancini L., Diehl, C. +269 morecore +1 more sourceHigh‐throughput development and scale‐up of recombinant adeno‐associated virus 5 anion‐exchange chromatography for high‐purity capsid separation
Biotechnology Progress, EarlyView.High‐throughput anion‐exchange chromatography process development enables scalable purification of high‐purity recombinant adeno‐associated virus capsids. Abstract
Recombinant adeno‐associated virus (rAAV) production commonly yields a high proportion of empty and partially filled capsids, necessitating downstream purification to enrich full capsids ...Kevin Vera, Ivan Gajic, Praveen Kusumanchi, Angela Andaluz, Gabrielle Dela Pena, Clifford A. Froelich, Elizabeth Higgins, Jennifer Johnston, Seyed Pouria Motevalian +8 morewiley +1 more source