Results 31 to 40 of about 8,586 (257)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

An energy-resolving photon-counting X-ray detector for computed tomography combining silicon-photomultiplier arrays and scintillation crystals

Communications Engineering
X-ray photon-counting computed tomography (PCCT) has garnered considerable interest owing to its low-dose administration, high-quality imaging, and material decomposition characteristics.
Kenji Shimazoe, Donghwan Kim, Moh Hamdan, Yosuke Kobayashi, Kei Kamada, Masao Yoshino, Yasuhiro Shoji, Kyohei Sakamoto, Fabio Acerbi, Alberto Gola   +9 more
doaj   +1 more source

Recent advances in single-photon detection towards the short-wave infrared spectral region

Advances in Physics: X
Single-photon detectors capable of detecting short-wave infrared (SWIR) light have undergone significant research and development over the past 30 years.
Lisa Saalbach, Fiona Fleming, Xin Yi, Gerald S. Buller   +3 more
doaj   +1 more source

Three-Dimensional Imaging via Time-Correlated Single-Photon Counting

Applied Sciences, 2020
Three-dimensional (3D) imaging under the condition of weak light and low signal-to-noise ratio is a challenging task. In this paper, a 3D imaging scheme based on time-correlated single-photon counting technology is proposed and demonstrated.
Chengkun Fu, Huaibin Zheng, Gao Wang, Yu Zhou, Hui Chen, Yuchen He, Jianbin Liu, Jian Sun, Zhuo Xu   +8 more
doaj   +1 more source

Photon-counting x-ray detectors for CT

Physics in Medicine & Biology, 2021
Abstract The introduction of photon-counting detectors is expected to be the next major breakthrough in clinical x-ray computed tomography (CT). During the last decade, there has been considerable research activity in the field of photon-counting CT, in terms of both hardware development and theoretical understanding of the factors ...
Mats Danielsson, Mats Persson, Martin Sjölin   +2 more
openaire   +3 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Photon-Counting Computed Tomography Angiography of Carotid Arteries: A Topical Narrative Review with Case Examples

Diagnostics
Photon counting computed tomography (PCCT) represents a paradigm shift from conventional CT imaging, propelled by a new generation of X-ray detectors capable of counting individual photons and measuring their energy.
Antonella Meloni, Riccardo Cau, Luca Saba, Vincenzo Positano, Carmelo De Gori, Mariaelena Occhipinti, Simona Celi, Eduardo Bossone, Jacopo Bertacchi, Bruna Punzo, Cesare Mantini, Carlo Cavaliere, Erica Maffei, Filippo Cademartiri   +13 more
doaj   +1 more source

Custom-Technology Single-Photon Avalanche Diode Linear Detector Array for Underwater Depth Imaging

Sensors, 2021
We present an optical depth imaging system suitable for highly scattering underwater environments. The system used the time-correlated single-photon counting (TCSPC) technique and the time-of-flight approach to obtain depth profiles.
Aurora Maccarone, Giulia Acconcia, Ulrich Steinlehner, Ivan Labanca, Darryl Newborough, Ivan Rech, Gerald S. Buller   +6 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source