Results 31 to 40 of about 738,419 (256)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The Effects of Spectral X-Ray Photon Counting Detector Parameters on Detector Performance: Thickness and Pitch

IEEE Access, 2020
The design of photon counting spectral imaging (x-CSI) X-ray detectors involves optimising many parameters including pixel thickness, pitch, and type of charge sharing correction algorithm (CSCA) employed, if any.
Oliver Len Paul Pickford Scienti, Jeffrey C. Bamber, Dimitra G. Darambara   +2 more
doaj   +1 more source

Real-time time correlated photon counters for photon number resolving detectors [PDF]

, 2020
In this paper, a novel Field Programmable Gate Array (FPGA) based instrument for Time Correlated Photon Counting (TCPC) is reported which takes advantage of the photon number resolving ability of newer single photon detectors technologies, such as ...
Sadik, Mala, Nock, Richard, Ai, Xiao, Lu, Yang   +3 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Microwave Kinetic Inductance Detectors [PDF]

, 2005
Low temperature detectors have been a subject of intense interest to the scientific community over the last decade. These detectors work at very low temperatures, often well below 1 Kelvin, to minimize the noise in the measurement of photons.
Mazin, Benjamin A.
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

An energy-resolving photon-counting X-ray detector for computed tomography combining silicon-photomultiplier arrays and scintillation crystals

Communications Engineering
X-ray photon-counting computed tomography (PCCT) has garnered considerable interest owing to its low-dose administration, high-quality imaging, and material decomposition characteristics.
Kenji Shimazoe, Donghwan Kim, Moh Hamdan, Yosuke Kobayashi, Kei Kamada, Masao Yoshino, Yasuhiro Shoji, Kyohei Sakamoto, Fabio Acerbi, Alberto Gola   +9 more
doaj   +1 more source

Recent advances in single-photon detection towards the short-wave infrared spectral region

Advances in Physics: X
Single-photon detectors capable of detecting short-wave infrared (SWIR) light have undergone significant research and development over the past 30 years.
Lisa Saalbach, Fiona Fleming, Xin Yi, Gerald S. Buller   +3 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Photon-Counting Computed Tomography Angiography of Carotid Arteries: A Topical Narrative Review with Case Examples

Diagnostics
Photon counting computed tomography (PCCT) represents a paradigm shift from conventional CT imaging, propelled by a new generation of X-ray detectors capable of counting individual photons and measuring their energy.
Antonella Meloni, Riccardo Cau, Luca Saba, Vincenzo Positano, Carmelo De Gori, Mariaelena Occhipinti, Simona Celi, Eduardo Bossone, Jacopo Bertacchi, Bruna Punzo, Cesare Mantini, Carlo Cavaliere, Erica Maffei, Filippo Cademartiri   +13 more
doaj   +1 more source