Results 41 to 50 of about 122,225 (247)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
International Journal of Physics and Applications, 2018 The atomic structure is presented on the basis of the theory of vortex gravitation. The feasibility and calculation of the values of the density and mass of electromagnetic particles are proposed. A calculation is made, which proves that the photon must have mass.
openaire +2 more sources
Nanophotonics, 2013 AbstractMultimode optical fibers have been primarily (and almost solely) used as “light pipes” in short distance telecommunications and in remote and astronomical spectroscopy. The modal properties of the multimode waveguides are rarely exploited and mostly discussed in the context of guiding light.
Leon-Saval Sergio G. +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Sistemas cuánticos individuales
Educación Química, 2013 Individual Quantum Systems The Nobel Prize in Physics for 2012 was awarded to Serge Haroche and David J. Wineland “for ground-breaking experimental methods that enable measuring and manipulation of individual quantum systems”.
Jorge A. Campos
doaj +1 more source
, 2018 The famous 1927 Solvay Conference was considered a turning point in the world of Physics. The scientific realists like Albert Einstein had lost and the instrumentalists like Niels Bohr had won the fundamental conflict. Since then Physics has followed the path of the instrumentalists in which Quantum Physics has been determined by the concept of ...
openaire +2 more sources
High-energy photon-photon colliders [PDF]
SPIE Proceedings, 1998 18 pages, Latex, 8 figures(eps), submitted to Proceedings of XI International Vavilov's Conference on nonlinear optics, Novosibirsk, June 24-28 ...
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Comparative proton and photon treatment plans in children treated for neuroblastoma
Acta OncologicaBackground and purpose: Neuroblastoma is the most common extracranial solid tumour in children. Radiotherapy is commonly part of the multimodal treatment for high-risk patients.
Anna Embring +9 more
doaj +1 more source