Results 101 to 110 of about 8,717 (203)

Differential stability of variant OPN1LW gene transcripts in myopic patients

Molecular Vision, 2019
Purpose: In Bornholm eye disease, a defect in the splicing of transcripts from a variant OPN1LW opsin gene leads to a depletion in spliced transcript levels and, consequently, a reduction in photopigment in photoreceptors expressing the variant gene ...
Jessica K. Mountford, Wayne I. L. Davies, Lyn R. Griffiths, Seyhan Yazar, David A. Mackey, David M. Hunt   +5 more
doaj  

Optogenetic interrogation reveals separable G-protein-dependent and -independent signalling linking G-protein-coupled receptors to the circadian oscillator

BMC Biology, 2017
Background Endogenous circadian oscillators distributed across the mammalian body are synchronised among themselves and with external time via a variety of signalling molecules, some of which interact with G-protein-coupled receptors (GPCRs).
Helena J. Bailes, Nina Milosavljevic, Ling-Yu Zhuang, Elliot J. Gerrard, Tomoki Nishiguchi, Takeaki Ozawa, Robert J. Lucas   +6 more
doaj   +1 more source

Reproducible and sustained regulation of Gαs signalling using a metazoan opsin as an optogenetic tool.

PLoS ONE, 2012
Originally developed to regulate neuronal excitability, optogenetics is increasingly also used to control other cellular processes with unprecedented spatiotemporal resolution. Optogenetic modulation of all major G-protein signalling pathways (Gq, Gi and
Helena J Bailes, Ling-Yu Zhuang, Robert J Lucas   +2 more
doaj   +1 more source

Identification and functional analysis of the vision-specific BBS3 (ARL6) long isoform.

PLoS Genetics, 2010
Bardet-Biedl Syndrome (BBS) is a heterogeneous syndromic form of retinal degeneration. We have identified a novel transcript of a known BBS gene, BBS3 (ARL6), which includes an additional exon.
Pamela R Pretorius, Lisa M Baye, Darryl Y Nishimura, Charles C Searby, Kevin Bugge, Baoli Yang, Robert F Mullins, Edwin M Stone, Val C Sheffield, Diane C Slusarski   +9 more
doaj   +1 more source

Different sensations from cones with the same photopigment

Journal of Vision, 2005
We used adaptive optics to study color fluctuation in the appearance of tiny flashes of light. For five subjects, near threshold, monochromatic stimuli with full widths at half maximum of 1/3 arcmin were delivered throughout a patch of retina near 1 deg in which we also determined the locations of L, M, and S cones.
Heidi, Hofer, Ben, Singer, David R, Williams   +2 more
openaire   +2 more sources

Sensory Systems as Cybernetic Systems that Require Awareness of Alternatives to Interact with the World: Analysis of the Brain-Receptor Loop in Norwich's Entropy Theory of Perception [PDF]

, 2009
Introduction & Objectives: Norwich’s Entropy Theory of Perception (1975 [1] -present) stands alone. It explains many firing-rate behaviors and psychophysical laws from bare theory.
Nizami, Lance
core  

Excitación melanopsinica en condiciones de iluminación natural y artificial

Anales (Asociación Física Argentina), 2018
Biological adaptation to sunlight evolved over millions of years. The intrusion of artificial lighting has disrupted this relationship with the natural environment.
O. U. Preciado, L. A. Issolio, E. Manzano, E. Colombo, P. A. Barrionuevo   +4 more
doaj  

Illumination by short-wavelength light inside the blind spot decreases light detectability

iScience
Summary: Although the optic disk corresponding to the blind spot contains no classical photoreceptors, it contains photopigment melanopsin. To clarify whether melanopsin is involved in light detection, we conducted detection tasks for light stimuli ...
Marina Saito, Kentaro Miyamoto, Ikuya Murakami   +2 more
doaj   +1 more source

Colour for behavioural success [PDF]

, 2018
Colour information not only helps sustain the survival of animal species by guiding sexual selection and foraging behaviour but also is an important factor in the cultural and technological development of our own species.
Dresp-Langley, Birgitta
core  

Formulae for generating standard and individual human cone spectral sensitivities. [PDF]

Color Res Appl, 2023
Stockman A, Rider AT.
europepmc   +1 more source