Results 81 to 90 of about 1,619 (156)

Reproducible and sustained regulation of Gαs signalling using a metazoan opsin as an optogenetic tool.

PLoS ONE, 2012
Originally developed to regulate neuronal excitability, optogenetics is increasingly also used to control other cellular processes with unprecedented spatiotemporal resolution. Optogenetic modulation of all major G-protein signalling pathways (Gq, Gi and
Helena J Bailes, Ling-Yu Zhuang, Robert J Lucas   +2 more
doaj   +1 more source

Melanopsin photopigment comes in two distinct forms. [PDF]

PLoS Biology, 2006
Mason Inman
doaj   +1 more source

Impaired Circadian Photoentrainment in Opn5-Null Mice

iScience, 2018
Summary: The master circadian pacemaker in mammals resides in the hypothalamic suprachiasmatic nuclei (SCN) and is synchronized to ambient light/dark cycles (i.e., photoentrainment). Melanopsin (Opn4) and classical rod-cone photoreceptors are believed to
Wataru Ota, Yusuke Nakane, Samer Hattar, Takashi Yoshimura   +3 more
doaj   +1 more source

Examining the role of the photopigment melanopsin in the striatal dopamine response to light

Frontiers in Systems Neuroscience
The mesolimbic dopamine system is a set of subcortical brain circuits that plays a key role in reward processing, reinforcement, associative learning, and behavioral responses to salient environmental events.
L. Sofia Gonzalez, L. Sofia Gonzalez, L. Sofia Gonzalez, Austen A. Fisher, Austen A. Fisher, Kassidy E. Grover, Kassidy E. Grover, Kassidy E. Grover, J. Elliott Robinson, J. Elliott Robinson   +9 more
doaj   +1 more source

Optogenetic interrogation reveals separable G-protein-dependent and -independent signalling linking G-protein-coupled receptors to the circadian oscillator

BMC Biology, 2017
Background Endogenous circadian oscillators distributed across the mammalian body are synchronised among themselves and with external time via a variety of signalling molecules, some of which interact with G-protein-coupled receptors (GPCRs).
Helena J. Bailes, Nina Milosavljevic, Ling-Yu Zhuang, Elliot J. Gerrard, Tomoki Nishiguchi, Takeaki Ozawa, Robert J. Lucas   +6 more
doaj   +1 more source

A psychophysical technique for measuring cone photopigment bleaching

, 1987
A new, clinically applicable test has been developed to measure the bleaching of the foveal cone photopigments. This noninvasive test is called steady-state color matching.
Louis A Lobes Jr, Bernard H Dofr, Ann E Eisner, Stephen A Burns   +3 more
core  

The HY5-PIF regulatory module coordinates light and temperature control of photosynthetic gene transcription.

PLoS Genetics, 2014
The ability to interpret daily and seasonal alterations in light and temperature signals is essential for plant survival. This is particularly important during seedling establishment when the phytochrome photoreceptors activate photosynthetic pigment ...
Gabriela Toledo-Ortiz, Henrik Johansson, Keun Pyo Lee, Jordi Bou-Torrent, Kelly Stewart, Gavin Steel, Manuel Rodríguez-Concepción, Karen J Halliday   +7 more
doaj   +1 more source

Excitación melanopsinica en condiciones de iluminación natural y artificial

Anales (Asociación Física Argentina), 2018
Biological adaptation to sunlight evolved over millions of years. The intrusion of artificial lighting has disrupted this relationship with the natural environment.
O. U. Preciado, L. A. Issolio, E. Manzano, E. Colombo, P. A. Barrionuevo   +4 more
doaj  

Melanopsin--shedding light on the elusive circadian photopigment

, 2004
Circadian photoentrainment is the process by which the brain's internal clock becomes synchronized with the daily external cycle of light and dark. In mammals, this process is mediated exclusively by a novel class of retinal ganglion cells that send ...
Brown, R Lane, Robinson, Phyllis R
core   +1 more source

Characterization of the light activated properties of the novel photopigment melanopsin

, 2008
. Using an in vitro biochemical approach to study the photochemical properties of heterologously expressed and endogenous melanopsin, I have demonstrated that melanopsin solubilized in detergent is sensitive to the ionic strength of the solution ...
Walker, Marquis T.
core   +1 more source