Results 21 to 30 of about 90,516 (199)

Development of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor Apoptosis

Pharmaceuticals, 2023
Treatment options are lacking to prevent photoreceptor death and subsequent vision loss. Previously, we demonstrated that reprogramming metabolism via the pharmacologic activation of PKM2 is a novel photoreceptor neuroprotective strategy.
Thomas J. Wubben, Sraboni Chaudhury, Brennan T. Watch, Jeanne A. Stuckey, Eric Weh, Roshini Fernando, Moloy Goswami, Mercy Pawar, Jason C. Rech, Cagri G. Besirli   +9 more
doaj   +1 more source

SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration

Life Science Alliance, 2020
This study reports that activation of SARM1 causes destruction of NAD pools in photoreceptor cells of the retina and identifies a role for SARM1-dependent photoreceptor cell death in retinal degeneration.
Ema Ozaki, Luke Gibbons, Nuno GB Neto, Paul Kenna, Michael Carty, Marian Humphries, Pete Humphries, Matthew Campbell, Michael Monaghan, Andrew Bowie, Sarah L Doyle   +10 more
doaj   +1 more source

A generalized equation for the calculation of receptor noise limited colour distances in n-chromatic visual systems [PDF]

Royal Society Open Science, 2017
Researchers must assess similarities and differences in colour from an animal's eye view when investigating hypotheses in ecology, evolution and behaviour.
R. C. Clark, R. D. Santer, J. S. Brebner   +2 more
doaj   +1 more source

The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa.

PLoS ONE, 2012
Most of inherited retinal diseases such as retinitis pigmentosa (RP) cause photoreceptor cell death resulting in blindness. RP is a large family of diseases in which the photoreceptor cell death can be caused by a number of pathways.
Takeshi Nakao, Motokazu Tsujikawa, Shoji Notomi, Yasuhiro Ikeda, Kohji Nishida   +4 more
doaj   +1 more source

Circadian Photoentrainment in Mice and Humans

Biology, 2020
Light around twilight provides the primary entrainment signal for circadian rhythms. Here we review the mechanisms and responses of the mouse and human circadian systems to light.
Russell G. Foster, Steven Hughes, Stuart N. Peirson   +2 more
doaj   +1 more source

Early manifestations and differential gene expression associated with photoreceptor degeneration in Prom1-deficient retina

Disease Models & Mechanisms, 2021
Retinitis pigmentosa (RP) and macular dystrophy (MD) are characterized by gradual photoreceptor death in the retina and are often associated with genetic mutations, including those in the prominin-1 (Prom1) gene. Prom1-knockout (KO) mice recapitulate key
Yuka Kobayashi, Shizuka Watanabe, Agnes Lee Chen Ong, Manabu Shirai, Chiemi Yamashiro, Tadahiko Ogata, Fumiaki Higashijima, Takuya Yoshimoto, Takahide Hayano, Yoshiyuki Asai, Noriaki Sasai, Kazuhiro Kimura   +11 more
doaj   +1 more source

Pineal photoreceptor cells are required for maintaining the circadian rhythms of behavioral visual sensitivity in zebrafish.

PLoS ONE, 2012
In non-mammalian vertebrates, the pineal gland functions as the central pacemaker that regulates the circadian rhythms of animal behavior and physiology. We generated a transgenic zebrafish line [Tg(Gnat2:gal4-VP16/UAS:nfsB-mCherry)] in which the E. coli
Xinle Li, Jake Montgomery, Wesley Cheng, Jung Hyun Noh, David R Hyde, Lei Li   +5 more
doaj   +1 more source

Phosphoinositide Profile of the Mouse Retina

Cells, 2020
Phosphoinositides are known to play multiple roles in eukaryotic cells. Although dysregulation of phosphoinositide metabolism in the retina has been reported to cause visual dysfunction in animal models and human patients, our understanding of the ...
Stella Finkelstein, Sidney M. Gospe, Kai Schuhmann, Andrej Shevchenko, Vadim Y. Arshavsky, Ekaterina S. Lobanova   +5 more
doaj   +1 more source

Dual-Cell Patch-Clamp Recording Revealed a Mechanism for a Ribbon Synapse to Process Both Digital and Analog Inputs and Outputs

Frontiers in Cellular Neuroscience, 2021
A chemical synapse is either an action potential (AP) synapse or a graded potential (GP) synapse but not both. This study investigated how signals passed the glutamatergic synapse between the rod photoreceptor and its postsynaptic hyperpolarizing bipolar
Ji-Jie Pang, Fan Gao, Samuel M. Wu
doaj   +1 more source

Mouse rods signal through gap junctions with cones

eLife, 2014
Rod and cone photoreceptors are coupled by gap junctions (GJs), relatively large channels able to mediate both electrical and molecular communication. Despite their critical location in our visual system and evidence that they are dynamically gated for ...
Sabrina Asteriti, Claudia Gargini, Lorenzo Cangiano   +2 more
doaj   +1 more source