Results 41 to 50 of about 90,516 (199)
Eupatilin Improves Cilia Defects in Human CEP290 Ciliopathy Models
Cells, 2023 The photoreceptor outer segment is a highly specialized primary cilium that is essential for phototransduction and vision. Biallelic pathogenic variants in the cilia-associated gene CEP290 cause non-syndromic Leber congenital amaurosis 10 (LCA10) and ...
Julio C. Corral-Serrano +8 more
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Polarized RPE Secretome Preserves Photoreceptors in Retinal Dystrophic RCS Rats
Cells, 2023 Retinal degenerative diseases, including age-related macular degeneration (AMD) and retinitis pigmentosa, lack effective therapies. Conventional monotherapeutic approaches fail to target the multiple affected pathways in retinal degeneration.
Kabir Ahluwalia +10 more
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Sphingolipids as Emerging Mediators in Retina Degeneration
Frontiers in Cellular Neuroscience, 2019 The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions.
M. Victoria Simón +3 more
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Guanylate cyclase 1 relies on rhodopsin for intracellular stability and ciliary trafficking
eLife, 2015 Sensory cilia are populated by a select group of signaling proteins that detect environmental stimuli. How these molecules are delivered to the sensory cilium and whether they rely on one another for specific transport remains poorly understood. Here, we
Jillian N Pearring +3 more
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Engineered MEVs for photoreceptor-targeted delivery of USP25 to alleviate diabetic retinopathy
Journal of NanobiotechnologyDiabetic retinopathy (DR) is the major cause of vision decline in adults worldwide. Photoreceptor loss is considered a main pathogenesis of retinal dysfunction in DR.
Yaoxiang Sun +9 more
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Oxidative Stress Induced Dysfunction of Protein Synthesis in 661W Mice Photoreceptor Cells
Proteomes, 2023 Photoreceptor cells are highly susceptible to oxidative-stress-induced damage due to their high metabolic rate. Oxidative stress plays a key role in driving pathological events in several different ocular diseases, which lead to retinal degeneration and ...
Liting Deng +11 more
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Frontiers in Physiology, 2014 In a microvillar photoreceptor, absorption of an incident photon initiates a phototransduction reaction that generates a depolarizing light-induced current in the microvillus.
Esa-Ville eImmonen +5 more
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Pharmaceutics, 2021 Gene and drug delivery to the retina is a critical therapeutic goal. While the majority of inherited forms of retinal degeneration affect the outer retina, specifically the photoreceptors and retinal pigment epithelium, effective targeted delivery to ...
Aiden Eblimit +8 more
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Cells, 2022 Retinal degeneration is a common feature in peroxisomal disorders leading to blindness. Peroxisomes are present in the different cell types of the retina; however, their precise contribution to retinal integrity is still unclear.
Daniëlle Swinkels +7 more
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Novel Porcine Retina Cultivation Techniques Provide Improved Photoreceptor Preservation
Frontiers in Neuroscience, 2020 Age-related macular degeneration (AMD) is the leading cause of blindness in industrialized countries among people over 60 years. It has multiple triggers and risk factors, but despite intense research efforts, its pathomechanisms are currently not ...
Natalie Wagner +7 more
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