Results 111 to 120 of about 4,871,943 (300)

A Rare Form of Microcephalic Primordial Dwarfism due to NSMCE2 Deficiency (Seckel Syndrome Type 10): A Report of Macular Involvement

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic variants in NSMCE2 (MMS21), which encodes the SUMO E3 ligase subunit of the SMC5/6 chromatin‐maintenance complex, have recently been implicated in microcephalic primordial dwarfism (MPD), corresponding to Seckel syndrome type 10 (OMIM #617246).
Cristina Peduto, Céline Huber, Clément Paya, Isabelle Audo, Nathalie Boddaert, Valérie Cormier‐Daire   +5 more
wiley   +1 more source

Near Infrared Photoswitching by Direct Excitation—A Next Frontier

Angewandte Chemie International Edition, EarlyView.
Molecular photoswitches finally enter the spectral realm of near‐infrared for their direct excitation. This minireview summarizes the current state‐of‐the‐art, the design principles for achieving such low‐energy light responsiveness, and the unique applications that are unlocked by it.
Diptiprava Sahoo, Elias Ciekalski, Henry Dube   +2 more
wiley   +1 more source

Ocular morphology and morphometry of the great egret (Ardea alba): A comprehensive anatomical description

The Anatomical Record, EarlyView.
Abstract Ardea alba (Linnaeus, 1758) is widely distributed, yet knowledge of its ocular morphology remains limited. This study described the morphometry and morphology of the eyeball and its accessory glands in six specimens using radiography, morphometry, light and scanning electron microscopy, and 3D scanning.
Julia Vaz Feio, Max Alex Santos Ferreira, Iara Fernanda Lima do Espírito Santo, Elane Guerreiro Giese, Érika Branco, Antônio Basílio Guerreiro Junior, Ana Rita de Lima   +6 more
wiley   +1 more source

Phototoxicity avoidance is a potential therapeutic approach for retinal dystrophy caused by EYS dysfunction

JCI Insight
Inherited retinal dystrophies (IRDs) are progressive diseases leading to vision loss. Mutation in the eyes shut homolog (EYS) gene is one of the most frequent causes of IRD.
Yuki Otsuka, Keiko Imamura, Akio Oishi, Kazuhide Asakawa, Takayuki Kondo, Risako Nakai, Mika Suga, Ikuyo Inoue, Yukako Sagara, Kayoko Tsukita, Kaori Teranaka, Yu Nishimura, Akira Watanabe, Kazuhiro Umeyama, Nanako Okushima, Kohnosuke Mitani, Hiroshi Nagashima, Koichi Kawakami, Keiko Muguruma, Akitaka Tsujikawa, Haruhisa Inoue   +20 more
doaj   +1 more source

Distribution of doublecortin in the developing retina of birds: A comparative analysis

The Anatomical Record, EarlyView.
Abstract The avian retina presents an elegant and highly accessible model for investigating the spatial and temporal dynamics of neurogenesis within the central nervous system. In recent years, the microtubule cytoskeleton has emerged not merely as a structural scaffold, but as a dynamic regulator of the transition of a morphologically homogeneous pool
Javier Francisco‐Morcillo, José Antonio de Mera‐Rodríguez, Violeta Calle‐Guisado, Gervasio Martín‐Partido, Joaquín Rodríguez‐León, Guadalupe Álvarez‐Hernán   +5 more
wiley   +1 more source

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

The Hippo pathway controls a switch between retinal progenitor cell proliferation and photoreceptor cell differentiation in zebrafish.

PLoS ONE, 2014
The precise regulation of numbers and types of neurons through control of cell cycle exit and terminal differentiation is an essential aspect of neurogenesis. The Hippo signaling pathway has recently been identified as playing a crucial role in promoting
Yoichi Asaoka, Shoji Hata, Misako Namae, Makoto Furutani-Seiki, Hiroshi Nishina   +4 more
doaj   +1 more source

Photoreceptor evolution: Ancient siblings serve different tasks

, 2005
Photoreceptor cells of vertebrate eyes are fundamentally different from those of invertebrate eyes. New work on the brain of a ragworm now suggests that ancestral bilaterians possessed both types of photoreceptor ...
Nilsson, Dan-E, Nilsson, Dan-E,, Lund University.   +2 more
core   +1 more source

Identification of Putative Cellulose Synthase Gene xcsA2 Required for c‐di‐GMP‐Induced Biofilm Formation and Cell Aggregation in Synechococcus elongatus PCC 7942

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Synechococcus elongatus PCC 7942 is a widely used model cyanobacterium for diverse research fields and for bioproduction applications owing to its ease of cultivation, genetic modification, and ability to fix CO2. We found that a laboratory strain of S. elongatus PCC 7942 expressing the ydeH gene from E.
Chihiro C. Yamaguchi, Jiro F. Mori, Shinsuke Kutsuna, Robert A. Kanaly   +3 more
wiley   +1 more source

The influence of circadian variables on ecotoxicology metabolomics

Biological Reviews, EarlyView.
ABSTRACT Ecotoxicologists are using metabolomics increasingly to gain insight into toxicological mechanisms and sublethal effects of chemical exposures. Metabolomics offers a sensitive multi‐parameter approach that can detect biochemical responses not obvious using apical and behavioural endpoints.
Ryan I. Lester, David J. Beale, Anthony R. Carroll, Steven D. Melvin   +3 more
wiley   +1 more source