Results 81 to 90 of about 4,764 (184)

Genome mining unearths a hybrid nonribosomal peptide synthetase-like-pteridine synthase biosynthetic gene cluster

eLife, 2017
Nonribosomal peptides represent a large class of metabolites with pharmaceutical relevance. Pteridines, such as pterins, folates, and flavins, are heterocyclic metabolites that often serve as redox-active cofactors.
Hyun Bong Park, Corey E Perez, Karl W Barber, Jesse Rinehart, Jason M Crawford   +4 more
doaj   +1 more source

Engineering Conditional Transgene Expression in Nicotiana benthamiana

Plant Biotechnology Journal, Volume 24, Issue 1, Page 18-30, January 2026.
ABSTRACT Nicotiana benthamiana has emerged as a premier plant biofactory for recombinant protein and metabolite production due to its high metabolic versatility, ease of cultivation and permissiveness to transient expression vectors. However, challenges such as transgene silencing, low yields and metabolic toxicity limit its scalability. Synthetic gene
Elena Garcia‐Perez, Marta Vazquez‐Vilar, Diego Orzaez   +2 more
wiley   +1 more source

Preliminary Screening on Antibacterial Crude Secondary Metabolites Extracted from Bacterial Symbionts and Identification of Functional Bioactive Compounds by FTIR, HPLC and Gas Chromatography–Mass Spectrometry

Molecules
Secondary metabolites, bioactive compounds produced by living organisms, can unveil symbiotic relationships in nature. In this study, soilborne entomopathogenic nematodes associated with symbiotic bacteria (Xenorhabdus stockiae and Photorhabdus ...
Gobinath Chandrakasan, Juan Fernando García-Trejo, Ana Angelica Feregrino-Pérez, Humberto Aguirre-Becerra, Enrique Rico García, María Isabel Nieto-Ramírez   +5 more
doaj   +1 more source

The loss of the urea cycle and ornithine metabolism in different insect orders: An omics approach

Insect Molecular Biology, Volume 34, Issue 5, Page 632-644, October 2025.
Among urea cycle enzymes, only the nitric oxide synthase gene is universally present across insect genomes. All Hemiptera species lack the enzymes needed to convert citrulline to arginine, and some also lack the pathway from arginine to ornithine. Putrescine and spermidine synthesis is conserved in all insects, but aphids lack the capability to produce
Jessica Cristina Silva Martins, Héctor Antônio Assunção Romão, Carolina Kurotusch Canettieri, Amanda Caetano Cercilian, Patrícia Rasteiro Ordiale Oliveira, Clelia Ferreira, Walter R. Terra, Renata de Oliveira Dias   +7 more
wiley   +1 more source

The Drosophila melanogaster Metabolic Response against Parasitic Nematode Infection Is Mediated by TGF-β Signaling

Microorganisms, 2020
The nematode Heterorhabditis bacteriophora, its mutualistic bacterium Photorhabdus luminescens, and the fruit fly Drosophila melanogaster establish a unique system to study the basis of infection in relation to host metabolism.
Yaprak Ozakman, Trishya Pagadala, Dhaivat Raval, Ioannis Eleftherianos   +3 more
doaj   +1 more source

Bacterial Glutamine Synthetases as a Novel Metabolic Selection Marker to Improve CHO Cell Culture Performance Through Selection Stringency Modulation

Biotechnology Journal, Volume 20, Issue 9, September 2025.
Graphical Abstract and Lay Summary Metabolic selection markers have improved stable cell line generation by enhancing productivity without relying on antibiotics. This study evaluated bacterial glutamine synthetases as novel selection markers in CHO cells, identifying variants that significantly increased antibody titers and revealed structural ...
Daniel Heinzelmann, Nicholas Michelarakis, Franziska Reuss, Benjamin Lindner, Anne R. Karow‐Zwick, Joschka Bauer, Benjamin Renner, Simon Fischer, Patrick Schulz, Moritz Schmidt   +9 more
wiley   +1 more source

Intestinal lipid droplets as novel mediators of host–pathogen interaction in Drosophila

Biology Open, 2019
Lipid droplets (LDs) are lipid-carrying multifunctional organelles, which might also interact with pathogens and influence the host immune response. However, the exact nature of these interactions remains currently unexplored.
Sneh Harsh, Christa Heryanto, Ioannis Eleftherianos   +2 more
doaj   +1 more source

Pertumbuhan Bakteri Photorhabdus luminescens pada Berbagai Media dan Produksi Eksotoksin sebagai Racun Serangga. [PDF]

, 2012
The aim of this experiment was to find out the type of medium that was potential for the metabolite production and growth of P. luminescens. LB, NB, Wakimoto, and T3 were examined as growth media for metabolite production and growth of P. luminescens. LB
PRIATNO, TRI PUJI, ., WARTONO
core  

Bacterial infection of a model insect: Photorhabdus luminescens and Manduca sexta

Cellular Microbiology, 2002
Invertebrates, including insects, are being developed as model systems for the study of bacterial virulence. However, we understand little of the interaction between bacteria and specific invertebrate tissues or the immune system. To establish an infection model for Photorhabdus, which is released directly into the insect blood system by its nematode ...
Carlos P, Silva, Nicholas R, Waterfield, Phillip J, Daborn, Paul, Dean, Timothy, Chilver, Candy P Y, Au, Sadhana, Sharma, Ursula, Potter, Stuart E, Reynolds, Richard H, ffrench-Constant   +9 more
openaire   +2 more sources

Drosophila melanogaster larvae are tolerant to oral infection with the bacterial pathogen Photorhabdus luminescens. [PDF]

MicroPubl Biol, 2023
Raval D, Daley L, Eleftherianos I.
europepmc   +1 more source