Results 61 to 70 of about 17,483 (248)

Cell migration is impaired in XPA‐deficient cells

FASEB BioAdvances, 2023
Xeroderma pigmentosum (XP) is a hereditary disorder characterized by photosensitivity, predisposition to skin cancers, and neurological abnormalities including microcephaly and progressive neurodegeneration.
Seiji Takeuchi, Takeshi Fukumoto, Chihiro Takemori, Naoaki Saito, Chikako Nishigori, Makoto Sato   +5 more
doaj   +1 more source

Waveguide Photoactuators: Materials, Fabrication, and Applications

Advanced Robotics Research, EarlyView.
Waveguide photoactuators convert guided light into mechanical motion. Their tethered‐flexible design enables minimally invasive surgery and confined‐space robotics. This review aims to guide materials selection, device design, and system integration, accelerating the transition of waveguide photoactuators from laboratory prototypes to versatile ...
Minjie Xi, Hemin Pan, Yang Zong, Yongfeng Mei, Jizhai Cui   +4 more
wiley   +1 more source

The face of Non‐photosensitive trichothiodystrophy phenotypic spectrum: A subsequent study on paediatric population

Molecular Genetics & Genomic Medicine
Background Non‐photosensitive trichothiodystrophies (TTDs) are a diverse group of genodermatoses within the subset of conditions known as “sulphur‐deficient brittle hair” syndromes.
Giulia Pascolini, Martina Lipari, Federica Gaudioso, Luca Fania, Giovanni Di Zenzo, Biagio Didona   +5 more
doaj   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Melanopsin, photosensitive ganglion cells, and seasonal affective disorder

Neuroscience & Biobehavioral Reviews, 2013
In two recent reports, melanopsin gene variations were associated with seasonal affective disorder (SAD), and in changes in the timing of sleep and activity in healthy individuals. New studies have deepened our understanding of the retinohypothalamic tract, which translates environmental light received by the retina into neural signals sent to a set of
Roecklein, Kathryn A, Wong, Patricia M, Miller, Megan A, Donofry, Shannon D, Kamarck, Marissa L, Brainard, George C   +5 more
openaire   +3 more sources

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Photodistributed toxic epidermal necrolysis in association with lamotrigine and tanning bed exposure

JAAD Case Reports, 2021
Kristen Russomanno, MD, Ashley DiLorenzo, MD, Joshua Horeczko, BA, Min Deng, MD, Michael Cardis, MD, Vesna Petronic-Rosic, MD, MSc, MBA, Laura S. Johnson, MD, Helena B. Pasieka, MD, MS   +7 more
doaj   +1 more source

KINDLER’S SYNDROME − A loss of identity

Pigment International
Kindler’s syndrome (KS) is a rare inherited skin disease characterized by acral blistering, photosensitivity, cutaneous atrophy, and progressive poikiloderma along with different types of mucosal involvement. We hereby report KS in a north eastern female
Bornali Dutta, Ravneet Kaur, Sarabjot Singh Anant   +2 more
doaj   +1 more source

Lipoic Acid‐Intervened Decellularized Stem Cell Spheroid‐Based Injectable Granular Gel for Diabetic Tissue Regeneration

Advanced Science, EarlyView.
ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang, Haowei Fang, Lili Qi, Song Myoungseop, Aawrish Khan, Lunli Gong, Guangdong Zhou, Kunxi Zhang, Haiyan Cui   +8 more
wiley   +1 more source