Two-Photon Excitation of Azobenzene Photoswitches for Synthetic Optogenetics
Applied Sciences, 2020 Synthetic optogenetics is an emerging optical technique that enables users to photocontrol molecules, proteins, and cells in vitro and in vivo. This is achieved by use of synthetic chromophores—denoted photoswitches—that undergo light ...
Shai Kellner, Shai Berlin
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Optocontrol of glutamate receptor activity by single side-chain photoisomerization
eLife, 2017 Engineering light-sensitivity into proteins has wide ranging applications in molecular studies and neuroscience. Commonly used tethered photoswitchable ligands, however, require solvent-accessible protein labeling, face structural constrains, and are ...
Viktoria Klippenstein +4 more
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2D-IR Study of a Photoswitchable Isotope-Labeled α-Helix [PDF]
, 2010 A series of photoswitchable, α-helical peptides were studied using two-dimensional infrared spectroscopy (2D-IR). Single-isotope labeling with 13C18O at various positions in the sequence was employed to spectrally isolate particular backbone positions ...
Backus, E H G +7 more
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Conductance of a single molecule anchored by an isocyanide substituent to gold electrodes [PDF]
, 2006 The effect of anchoring group on the electrical conductance of a single molecule bridging two Au electrodes was studied using di-substituted (isocyanide (CN-), thiol (S-) or cyanide (NC-)) benzene.
Cunningham I. D. +5 more
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Design, Synthesis and Inhibitory Activity of Photoswitchable RET Kinase Inhibitors. [PDF]
, 2015 REarranged during Transfection (RET) is a transmembrane receptor tyrosine kinase required for normal development and maintenance of neurons of the central and peripheral nervous systems.
Andréasson, Joakim +4 more
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Inducible fluorescent speckle microscopy [PDF]
, 2016 The understanding of cytoskeleton dynamics has benefited from the capacity to generate fluorescent fiducial marks on cytoskeleton components. Here we show that light-induced imprinting of three-dimensional (3D) fluorescent speckles significantly improves
António J. Pereira +39 more
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Robust photoregulation of GABA(A) receptors by allosteric modulation with a propofol analogue. [PDF]
, 2012 Photochemical switches represent a powerful method for improving pharmacological therapies and controlling cellular physiology. Here we report the photoregulation of GABA(A) receptors (GABA(A)Rs) by a derivative of propofol (2,6-diisopropylphenol), a ...
Bruzik, Karol S +8 more
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Functional characterization of a constitutively active kinase variant of Arabidopsis phototropin 1 [PDF]
, 2017 Phototropins (phots) are plasma membrane-associated serine/threonine kinases that coordinate a range of processes linked to optimizing photosynthetic efficiency in plants.
Christie, John M. +5 more
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Optical control of PIEZO1 channels
Nature Communications, 2023 PIEZO proteins are large, mechanically-activated trimeric ion channels. Here the authors report a light-gated mouse PIEZO1 channel, mOP1, whereby an azobenzene-based photoswitch covalently localised at the extracellular apex of a transmembrane helix ...
Francisco Andrés Peralta +8 more
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Vinylene-Linked Covalent Organic Frameworks by Base-Catalyzed Aldol Condensation [PDF]
, 2019 Two 2D covalent organic frameworks (COFs) linked by vinylene (−CH=CH−) groups (V‐COF‐1 and V‐COF‐2) are synthesized by exploiting the electron deficient nature of the aromatic s‐triazine unit of C3‐symmetric 2,4,6‐trimethyl‐s‐triazine (TMT).
Acharjya, Amitava +4 more
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