Application of photopharmacology in agrochemicals
Advanced Agrochem, 2023 Photopharmacology is a novel technology in drug design that aims at solving poor drug selectivity. This technology is currently in the proof-of-concept phase and relies on the photoactivation or inactivation of photochromic ligands (PCLs) to regulate ...
Wen Fu, Zhong Li, Xusheng Shao
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Recent Advances of Azobenzene-Based Photoresponsive Molecular Switches for Protein-Targeted Photopharmacology [PDF]
MoleculesAzobenzene derivatives constitute a prototypical class of photoresponsive molecular switches with broad utility in synthetic chemistry and biomedical research, owing to their distinctive physicochemical properties.
Jingyu Jiang, Xinrui Yuan, Lei Hu
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Photopharmacology of Proteolysis-Targeting Chimeras: A New Frontier for Drug Discovery
Frontiers in Chemistry, 2021 Photopharmacology is an emerging field that uses light to precisely control drug activity. This strategy promises to improve drug specificity for reducing off-target effects.
Shenxin Zeng +7 more
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Photopharmacology reveals high-specificity linkage of Ca2+ entry at TRPC6 nanodomains to NFAT activation in mast cells [PDF]
Frontiers in ImmunologyIntroductionPhotopharmacology has recently emerged as a strategy for high-precision modulation of immune functions. Here we explored efficiency and specificity of interventions based on light-induced TRPC6 activation in the RBL-2H3 mast cell model ...
Denis Krivić +10 more
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Recent advances in photopharmacology: Harnessing visible light‐activated azobenzene photoswitches
Responsive MaterialsIn the era of precision medicine, photopharmacology that employs molecular photoswitches offers unique opportunities to control the action of bioactive molecules with high spatiotemporal resolution, while reducing drug side effects, systemic toxicity and
Yongliang Feng +7 more
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FEBS Open BioIntracellular Ca2+ regulates insulin secretion from pancreatic β‐cells and is influenced by cannabinoid signaling. However, the hydrophobicity and complex pharmacology of cannabinoid ligands prevent precision receptor targeting, limiting our ...
Alexander E. G. Viray, James A. Frank
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New Visible-Light-Sensitive Dicyanocoumarin- and COUPY-Based Caging Groups with Improved Photolytic Efficiency [PDF]
MoleculesPhotolabile protecting groups (PPGs), also known as caging groups, are valuable tools in photopharmacology. They enable precise control over the release of bioactive compounds from the corresponding caged compounds at a precisely controlled time and ...
Marta López-Corrales, Vicente Marchán
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Photopharmacological modulation of hippocampal local field potential by caged‐glutamate with MicroLED probe [PDF]
Neuropsychopharmacology ReportsAim Photopharmacology is a new technique for modulating biological phenomena through the photoconversion of substances in a specific target region at precise times.
Shogo Okada +7 more
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Synthesis and Study of Substituted Chalcones Combined with Fluoroazobenzenes—New Photoswitches for Application in Biological Systems [PDF]
MoleculesChalcones have garnered significant research interest due to their various medical bioactivities. Several chalcone compounds have been approved for marketing and clinical use in the treatment of various diseases.
Piotr Tobiasz +5 more
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Photomodulation Approaches to Overcome Antimicrobial Resistance
Pharmaceuticals, 2023 Photopharmacology is an approach that aims to be an alternative to classical chemotherapy. Herein, the different classes of photoswitches and photocleavage compounds and their biological applications are described. Proteolysis targeting chimeras (PROTACs)
Sofia N. Sarabando +4 more
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