Results 1 to 10 of about 964 (143)

Recent Advances in Photopharmacology: Harnessing Visible Light-Activated Azobenzene Photoswitches

Responsive materials
In the era of precision medicine, photopharmacology that employs molecular photoswitches offers unique opportunities to control the action of bioactive molecules with high spatiotemporal resolution, while reducing drug side effects, systemic toxicity and
Ziyong Li, Hong-Ru Fu, Yongliang Feng
exaly   +3 more sources

Application of Photopharmacology in Agrochemicals

Advanced Agrochem, 2023
Photopharmacology is a novel technology in drug design that aims at solving poor drug selectivity. This technology is currently in the proof-of-concept phase and relies on the photoactivation or inactivation of photochromic ligands (PCLs) to regulate ...
Xusheng Shao, Wen Fu
exaly   +4 more sources

Photopharmacology Beyond Azobenzene Photoswitches

Responsive materials
Photopharmacology harnesses photoswitchable molecules to reversibly and precisely modulate biological activities, offering exceptional spatial and temporal control through non‐invasive illumination.
Junji Zhang, Jinghong Dai
exaly   +3 more sources

Photopharmacology of Proteolysis-Targeting Chimeras: A New Frontier for Drug Discovery

Frontiers in Chemistry, 2021
Photopharmacology is an emerging field that uses light to precisely control drug activity. This strategy promises to improve drug specificity for reducing off-target effects.
Zhengrong Shen, Wenhai Huang, Hongjie Zhang   +2 more
exaly   +3 more sources

Photomodulation Approaches to Overcome Antimicrobial Resistance

Pharmaceuticals, 2023
Photopharmacology is an approach that aims to be an alternative to classical chemotherapy. Herein, the different classes of photoswitches and photocleavage compounds and their biological applications are described. Proteolysis targeting chimeras (PROTACs)
Sofia N. Sarabando, Andreia Palmeira, Maria Emília Sousa, Maria Amparo F. Faustino, Carlos J. P. Monteiro   +4 more
doaj   +2 more sources

All-in-One Photoactivated Inhibition of Butyrylcholinesterase Combined with Luminescence as an Activation and Localization Indicator: Carbon Quantum Dots@Phosphonate Hybrids [PDF]

Nanomaterials, 2023
Photopharmacology is a booming research area requiring a new generation of agents possessing simultaneous functions of photoswitching and pharmacophore.
Gulia Bikbaeva, Anna Pilip, Anastasia Egorova, Ilya Kolesnikov, Dmitrii Pankin, Kirill Laptinskiy, Alexey Vervald, Tatiana Dolenko, Gerd Leuchs, Alina Manshina   +9 more
doaj   +2 more sources

Photochemical Restoration of Light Sensitivity in the Degenerated Canine Retina

Pharmaceutics, 2022
Photopharmacological compounds such as azobenzene-based photoswitches have been shown to control the conductivity of ionic channels in a light-dependent manner and are considered a potential strategy to restore vision in patients with end-stage ...
Sergei Nikonov, Natalia Dolgova, Raghavi Sudharsan, Ivan Tochitsky, Simone Iwabe, Jose-Manuel Guzman, Russell N. Van Gelder, Richard H. Kramer, Gustavo D. Aguirre, William A. Beltran   +9 more
doaj   +1 more source

Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity

Molecules, 2023
The multitarget therapeutic strategy, as opposed to the more traditional ‘one disease-one target-one drug’, may hold promise in treating multifactorial neurodegenerative syndromes, such as Alzheimer’s disease (AD) and related dementias.
Marco Paolino, Modesto de Candia, Rosa Purgatorio, Marco Catto, Mario Saletti, Anna Rita Tondo, Orazio Nicolotti, Andrea Cappelli, Antonella Brizzi, Claudia Mugnaini, Federico Corelli, Cosimo D. Altomare   +11 more
doaj   +1 more source

Photoresponsive prodrug‐dye nanoassembly for in‐situ monitorable cancer therapy

Bioengineering & Translational Medicine, 2022
Photocleavable prodrugs enable controllable drug delivery to target sites modulated by light irradiation. However, the in vivo utility is usually hindered by their insolubility and inefficient delivery.
Kaiqi Long, Yifan Wang, Wen Lv, Yang Yang, Shuting Xu, Changyou Zhan, Weiping Wang   +6 more
doaj   +1 more source

A Solid-State Fluorescence Switch Based on Triphenylethene-Functionalized Dithienylethene With Aggregation-Induced Emission

Frontiers in Chemistry, 2021
The development of novel dithienylethene-based fluorescence switches in the aggregated state, and the solid state is highly desirable for potential application in the fields of optoelectronics and photopharmacology.
Haining Zhang, Xiaoxiao Hu, Huijuan Zhu, Limin Shen, Congmin Liu, Xiaoman Zhang, Xinyu Gao, Lingmei Li, Yan-Ping Zhu, Ziyong Li   +9 more
doaj   +1 more source