Results 31 to 40 of about 2,002 (201)
Structural Aspects of Photopharmacology: Insight into the Binding of Photoswitchable and Photocaged Inhibitors to the Glutamate Transporter Homologue [PDF]
, 2021 Photopharmacology addresses the challenge of drug selectivity and side effects through creation of photoresponsive molecules activated with light with high spatiotemporal precision.
Arkhipova, Valentina +10 more
core +1 more source
Optical control of insulin secretion using an incretin switch [PDF]
, 2015 Incretin mimetics are set to become a mainstay of type 2 diabetes treatment. By acting on the pancreas and brain, they potentiate insulin secretion and induce weight loss to preserve normoglycemia.
Aemissegger +30 more
core +1 more source
Pharmaceuticals, 2021 The scavenging effect of the antimetabolite dihydrofolate reductase inhibitor methotrexate (MTX) and the isomers of its photoswitchable derivate, cis- and trans-phototrexate (PHX), have been compared by ESR spectroscopy, with the application of a cyclic ...
Zsolt Preisz +4 more
doaj +1 more source
Azobenzene photocontrol of peptides and proteins [PDF]
, 2016 The last few years have witnessed significant advances in the use of light as a stimulus to control biomolecular interactions. Great efforts have been devoted to the development of genetically encoded optobiological and small photochromic switches. Newly
Allemann, Rudolf, Mart, Robert
core +1 more source
Nature Communications, 2022 Wireless delivery of both light and pharmacological agents is important for optogenetic and other mechanistic experiments in the brain. Here the authors present a wireless real-time programmable optofluidic platform that enables optogenetics and ...
Yixin Wu +26 more
doaj +1 more source
Design, Synthesis and Inhibitory Activity of Photoswitchable RET Kinase Inhibitors. [PDF]
, 2015 REarranged during Transfection (RET) is a transmembrane receptor tyrosine kinase required for normal development and maintenance of neurons of the central and peripheral nervous systems.
Andréasson, Joakim +4 more
core +1 more source
Isomerisation of an intramolecular hydrogen-bonded photoswitch:Protonated azobis(2-imidazole) [PDF]
, 2017 Photoisomerisation of protonated azobis(2-imidazole), an intramolecular hydrogen-bonded azoheteroarene photoswitch molecule, is investigated in the gas phase using tandem ion mobility mass spectrometry.
Bieske, Evan J. +3 more
core +2 more sources
Three‐Photon Infrared Stimulation of Endogenous Neuroreceptors in Vivo [PDF]
, 2023 To interrogate neural circuits and crack their codes, in vivo brain activity imaging must be combined with spatiotemporally precise stimulation in three dimensions using genetic or pharmacological specificity. This challenge requires deep penetration and
Agnetta, Luca +13 more
core +1 more source
Development of a Dosage form for a Photoswitchable Local Anesthetic Ethercaine
Pharmaceuticals, 2023 The toxicity of local anesthetics is a serious problem, given their widespread use. One of the main causes of the side effects of local anesthetics is their non-selectivity of action in the body.
Alexey Noev +5 more
doaj +1 more source
Remote light-controlled intracellular target recognition by photochromic fluorescent glycoprobes [PDF]
, 2017 Development of powerful fluorescence imaging probes and techniques sets the basis for the spatiotemporal tracking of cells at different physiological and pathological stages.
Feringa, Ben L. +7 more
core +2 more sources