Results 31 to 40 of about 964 (143)
Angewandte Chemie, EarlyView.This study investigates the influence of several substituents at different positions on photochemical and thermal properties of azobenzene‐based materials to provide valuable structure‐property relationships for the specific design of azobenzene‐based materials for future energy storage and phase change materials. ABSTRACT Understanding and translating
Conrad Averdunk, Hermann A. Wegner
wiley +2 more sources
Nature Communications, 2022 Wireless delivery of both light and pharmacological agents is important for optogenetic and other mechanistic experiments in the brain. Here the authors present a wireless real-time programmable optofluidic platform that enables optogenetics and ...
Yixin Wu +26 more
doaj +1 more source
In vivo photopharmacology with a caged mu opioid receptor agonist drives rapid changes in behavior [PDF]
, 2023 Photoactivatable drugs and peptides can drive quantitative studies into receptor signaling with high spatiotemporal precision, yet few are compatible with behavioral studies in mammals.
Shannan P. McClain +17 more
core +1 more source
Optical Control of the Glucocorticoid Receptor Activity With a Photoswitchable Agonist
Angewandte Chemie, EarlyView.A photoswitchable glucocorticoid receptor agonist enables optical control of receptor activity, achieving picomolar potency and partial agonism that preferentially maintains anti‐inflammatory signaling over canonical transcriptional activation. ABSTRACT Glucocorticoids (GCs) are widely prescribed anti‐inflammatory agents whose clinical utility is ...
Zoe Sessions +8 more
wiley +2 more sources
Engineering Rapid Payload Release Rate in 1,6‐Elimination Processes of Self‐Immolative Linkers
Angewandte Chemie, EarlyView.The payload release rate of self‐immolative linkers was greatly improved through stabilization of an intermediate carbocation, thereby achieving an up to 10 000‐fold improvement in rate constant. Furthermore, lipophilicity was identified as another factor that affects the release rate. This new strategy is applicable to different payloads and different
Albert Marten Schulte +4 more
wiley +2 more sources
Development of a Dosage form for a Photoswitchable Local Anesthetic Ethercaine
Pharmaceuticals, 2023 The toxicity of local anesthetics is a serious problem, given their widespread use. One of the main causes of the side effects of local anesthetics is their non-selectivity of action in the body.
Alexey Noev +5 more
doaj +1 more source
Substituted nitrogen-bridged diazocines
Beilstein Journal of Organic Chemistry, 2021 Novel nitrogen-bridged diazocines (triazocines) were synthesized that carry a formyl or an acetyl group at the CH2NR-bridge and bromo- or iodo-substituents at the distant phenyl ring.
Pascal Lentes +3 more
doaj +1 more source
Optochemical Control of Immune Checkpoint Blockade via Light‐Triggered PD‐L1 Dimerization
Advanced NanoBiomed Research, 2022 The blockade of PD‐1/PD‐L1, which serves to “release the brake” of tumor immunity, represents a promising approach for treating various malignancies. However, the systemic immune‐related side effects significantly undermine its therapeutic efficacy.
Yuwei Liu +4 more
doaj +1 more source
Photopharmacological Control of Cyclic Antimicrobial Peptides
ChemBioChem, 2018 AbstractGramicidin S is a naturally occurring antimicrobial cyclic peptide. Herein, we present a series of cyclic peptides based on gramicidin S that contain an azobenzene photoswitch to reversibly control secondary structure and, hence, antimicrobial activity.
Yuan Qi Yeoh +4 more
openaire +4 more sources
Frontiers in Immunology, 2020 Canonical transient receptor potential (TRPC) channels are considered as elements of the immune cell Ca2+ handling machinery. We therefore hypothesized that TRPC photopharmacology may enable uniquely specific modulation of immune responses.
Bernadett Bacsa +7 more
doaj +1 more source