Results 51 to 60 of about 2,002 (201)
Frontiers in Immunology, 2020 Canonical transient receptor potential (TRPC) channels are considered as elements of the immune cell Ca2+ handling machinery. We therefore hypothesized that TRPC photopharmacology may enable uniquely specific modulation of immune responses.
Bernadett Bacsa +7 more
doaj +1 more source
Sensitized Disequilibration of Water‐Soluble Azopolymers
Angewandte Chemie, Volume 138, Issue 7, 9 February 2026.Disequilibration by sensitization under confinement (DESC) is a promising strategy for efficient visible‐light‐induced azobenzene E→Z isomerization. In this article, we explored key factors for adapting DESC to azopolymers, eventually achieving efficiencies up to 85% compared to direct excitation and laying the foundation for more complex systems ...
Henning Jörn Meteling +4 more
wiley +2 more sources
Biaryl sulfonamides as cisoid azosteres for photopharmacology
Chemical Communications, 2021 Biaryl sulfonamides are excellent candidates for the azologization approach that yields photoswitchable drugs more active in their metastable cis state, compared to the stable trans state.
Piermichele Kobauri +7 more
openaire +3 more sources
Hemithioindigos for cellular tubulin photopharmacology: From proof of concept to near-quantitatively photoswitchable tools with single-cell precision [PDF]
, 2022 Microtubules (MTs) are hollow polymeric tubes formed of α/β-tubulin heterodimers that are in a constant dynamic equilibrium between growth and shrinkage. MTs are an essential constituent of the cytoskeleton and so are critical in many cellular processes,
Sailer, Alexander
core
First-in-Class Colchicine-Based Visible Light Photoswitchable Microtubule Dynamics Disrupting Agent
Cells, 2023 Compounds that disrupt microtubule dynamics, such as colchicine, paclitaxel, or Vinca alkaloids, have been broadly used in biological studies and have found application in clinical anticancer medications.
Filip Borys +4 more
doaj +1 more source
Angewandte Chemie International Edition, EarlyView.Novel and biocompatible photoactivatable oxytocin and vasopressin probes, utilising state‐of‐the‐art photocages, remain inactive in the dark. Light exposure facilitates rapid spatiotemporal receptor activation and phospholipase C (PLC)‐mediated downstream signalling. Figure created in https://BioRender.com.
Konstantin Raabe +7 more
wiley +1 more source
Photoswitchable basicity through the use of azoheteroarenes
, 2016 We report an azoheteroarene photoswitchable base, where proton stabilisation in Z isomer is facilitated by neighbouring imidazole rings. A 1.3 unit difference in pKa is observed between the E and Z isomers, which leads to the ability to reversibly ...
Fuchter, MJ, Richardson, RD, Weston, CE
core +1 more source
Beilstein Journal of Organic Chemistry, 2020 This study evaluates the embryotoxicity of dithienylethene-modified peptides upon photoswitching, using 19 analogues based on the β-hairpin scaffold of the natural membranolytic peptide gramicidin S.
Sergii Afonin +7 more
doaj +1 more source
Dynamic Control of Nucleic Acids Self‐Assembly and Expression Using Photoswitches
Chemistry – A European Journal, EarlyView.We review here the recent progress made in the design of molecular photoswitches, and highlight their implementation for the dynamic control over nucleic acids self‐assembly and expression. ABSTRACT Synthetic nucleic acids have become readily available and now constitute versatile building blocks in materials science—where they can be used to engineer ...
Noemí Nogal +4 more
wiley +1 more source
Photopharmacological Tools for Mitotic Cell Division
YAKUGAKU ZASSHI, 2022 Genetic information is replicated and transmitted from a parent cell to two identical daughter cells through mitotic cell division. To accomplish this dynamic process with high accuracy and precision, various motor proteins work in a concerted manner.
openaire +2 more sources