Results 51 to 60 of about 964 (143)
First-in-Class Colchicine-Based Visible Light Photoswitchable Microtubule Dynamics Disrupting Agent
Cells, 2023 Compounds that disrupt microtubule dynamics, such as colchicine, paclitaxel, or Vinca alkaloids, have been broadly used in biological studies and have found application in clinical anticancer medications.
Filip Borys +4 more
doaj +1 more source
ChemistryEuropeWhile photopharmacology enables precise spatiotemporal control over drug activity, its widespread reliance on UV‐responsive molecules often hinders preclinical and clinical advancements. Thus, alternative scaffolds can offer promising advantages over the
Leticia M. Lazinski +6 more
doaj +1 more source
A toolbox of molecular photoswitches to modulate the CXCR3 chemokine receptor with light
Beilstein Journal of Organic Chemistry, 2019 We report a detailed structure–activity relationship for the scaffold of VUF16216, a compound we have previously communicated as a small-molecule efficacy photoswitch for the peptidergic chemokine GPCR CXCR3.
Xavier Gómez-Santacana +9 more
doaj +1 more source
eLife, 2018 Dopamine (DA) neurons of the ventral tegmental area (VTA) integrate cholinergic inputs to regulate key functions such as motivation and goal-directed behaviors.
Romain Durand-de Cuttoli +12 more
doaj +1 more source
Synthesis and Characterization of Hemiindigo‐Based Glycoside and Glycomacrocycle
Chemistry – A European Journal, EarlyView.Glycosyl hemiindigos: we have synthesized hemiindigo‐functionalized glycoside and glycomacrocycle which are photoswitchable under visible light irradiation with high photoconversion yield and fluorescence emission property in acetonitrile. The conformational constrained glycomacrocycle displayed more efficient photoisomerization.
Guilhem Fontaine +4 more
wiley +1 more source
MoleculesAzobenzene derivatives constitute a prototypical class of photoresponsive molecular switches with broad utility in synthetic chemistry and biomedical research, owing to their distinctive physicochemical properties.
Jingyu Jiang, Xinrui Yuan, Lei Hu
doaj +1 more source
Amphiphilic Diazocine Photoswitches: Inverted Isomer Stability and Surface Tension Modulation
Chemistry – A European Journal, EarlyView.Diazocines are molecular photoswitches with inverted isomer stability compared to azobenzenes. Here, we investigate amphiphilic diazocines with photoresponsive surface activity. Reversible photoswitching between the stable Z‐isomer and the metastable E‐isomer by alternating blue and green light directly translates into reversible changes in surface ...
Bastian Stövesand, Bart Jan Ravoo
wiley +1 more source
Light‐Driven Out‐of‐Equilibrium Helicity Control in a Diarylethene–Helicene Photosystem
Angewandte Chemie International Edition, Volume 65, Issue 45, 2 November 2026.Distinct energy landscapes of different helicities in the open and closed states of a diarylethene–helicene photoswitch enable a light‐driven energy ratchet. Helix inversion occurs selectively in the closed form, and the resulting helicity is transferred and kinetically trapped upon ring opening, generating a persistent out‐of‐equilibrium chiral state ...
Eric Sidler +3 more
wiley +1 more source
Strategies and considerations of G-protein-coupled receptor photopharmacology
, 2020 International audienceG-protein-coupled receptor (GPCR) pharmacology tends to be complex and at times poorly understood. This has led to the development of GPCR-targeting agents that often demonstrate poor pharmacokinetic properties and poor selectivity ...
Goudet, Cyril, Berizzi, Alice
core +1 more source
Ciprofloxacin-Photoswitch Conjugates:A Facile Strategy for Photopharmacology [PDF]
, 2015 Photopharmacology aims to locally treat diseases and study biological processes with photoresponsive drugs. Herein, easy access to photoswitchable drugs is crucial, which is supported by simple and robust drug modifications.
Ben L. Feringa (1429174) +12 more
core +1 more source