Results 61 to 70 of about 2,002 (201)

Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock [PDF]

, 2021
CRY1 and CRY2 proteins are highly conserved components of the circadian clock that controls daily physiological rhythms. Disruption of CRY functions are related to many diseases, including circadian sleep phase disorder.
Amaike, Kazuma, Aoki, Yugo, Feringa, Ben L., Hirota, Tsuyoshi, Itami, Kenichiro, Kobauri, Piermichele, Kolarski, Dušan, Miller, Simon, Nagai, Yoshiko, Oshima, Tsuyoshi, Sato, Ayato, Srivastava, Ashutosh, Sugiyama, Akiko, Szymanski, Wiktor, Tama, Florence   +14 more
core   +1 more source

The photoswitchable ABAMIs for the future regulation of GWT1 in a spatiotemporal level

Smart Molecules, EarlyView.
The GWT1‐targeted azobenzene‐aminopyridine derivatives (ABAMIs), sensitive to the light at wavelengths from 365 to 520 nm, are separately developed as photochromic ligands to regulate bioactivity as well as the GWT1 functions. These molecules are smart tools in photopharmacological studies, giving an innovative method for understanding functional GWT1 ...
Qian Ding, Zongying Li, Zaiwei Xiao, Siting Zhang, Zimai Liu, Xiaoguang Shao, Zhong Li, Wen Fu, Xusheng Shao   +8 more
wiley   +1 more source

Thermally Bistable Stiff Stilbene Photoswitches and Polymer Applications

The Chemical Record, EarlyView.
Thermally stable photoswitches offer new opportunities for controlling polymer structures and functions under nonequilibrium conditions. This Personal Account highlights stiff stilbene (SS) and sterically hindered stiff stilbene (HSS) photoswitches, which combine large structural changes with exceptional thermal bistability.
Keiichi Imato
wiley   +1 more source

Chronophotopharmacology:towards chronotherapy with high spatio-temporal precision [PDF]

, 2020
Even the most sophisticated watches are imperfect timekeepers and their ability to measure time is affected throughout their lifespan. This problem can be solved by mechanical adjustment or a battery replacement.
Kolarski, Dusan
core   +1 more source

Reductive stability evaluation of 6-azopurine photoswitches for the regulation of CKI alpha activity and circadian rhythms [PDF]

, 2021
Photopharmacology develops bioactive compounds whose pharmacological potency can be regulated by light. The concept relies on the introduction of molecular photoswitches, such as azobenzenes, into the structure of bioactive compounds, such as known ...
Feringa, Ben L., Hirota, Tsuyoshi, Itami, Kenichiro, Kolarski, Dusan, Peifer, Christian, Rodat, Theo, Schulte, Albert, Sugiyama, Akiko, Szymanski, Wiktor   +8 more
core   +1 more source

Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors

eLife, 2018
Dopamine (DA) neurons of the ventral tegmental area (VTA) integrate cholinergic inputs to regulate key functions such as motivation and goal-directed behaviors.
Romain Durand-de Cuttoli, Sarah Mondoloni, Fabio Marti, Damien Lemoine, Claire Nguyen, Jérémie Naudé, Thibaut d'Izarny-Gargas, Stéphanie Pons, Uwe Maskos, Dirk Trauner, Richard H Kramer, Philippe Faure, Alexandre Mourot   +12 more
doaj   +1 more source

Feedback control of excitability and high K+ induced epileptiform bursts in male rat hippocampal slices with a photocaged adenosine A1 receptor agonist

British Journal of Pharmacology, Volume 183, Issue 10, Page 2578-2591, May 2026.
Background and Purpose Adenosine is a potent regulator of neurotransmission and neuronal excitability, through activation of Gi coupled adenosine A1 receptors (A1Rs). Adenosine has gained interest as an anticonvulsant because of its endogenous involvement in ending seizure activity, but peripheral side effects require local application.
Erine Craey, Marijke Vergaelen, Serge Van Calenbergh, Jeroen Spanoghe, Evelien Carrette, Kristl Vonck, Paul Boon, Wytse J. Wadman, Robrecht Raedt   +8 more
wiley   +1 more source

Reducing the Formation of Toxic Byproducts During the Photochemical Release of Epinephrine

Journal of Xenobiotics
Engineered light-sensitive molecules offer a sophisticated toolkit for the manipulation of biological systems with both spatial and temporal precision.
Mikhail A. Panfilov, Ezhena S. Starodubtseva, Tatyana Yu. Karogodina, Alexey Yu. Vorob’ev, Alexander E. Moskalensky   +4 more
doaj   +1 more source

A toolbox of molecular photoswitches to modulate the CXCR3 chemokine receptor with light

Beilstein Journal of Organic Chemistry, 2019
We report a detailed structure–activity relationship for the scaffold of VUF16216, a compound we have previously communicated as a small-molecule efficacy photoswitch for the peptidergic chemokine GPCR CXCR3.
Xavier Gómez-Santacana, Sabrina M. de Munnik, Tamara A. M. Mocking, Niels J. Hauwert, Shanliang Sun, Prashanna Vijayachandran, Iwan J. P. de Esch, Henry F. Vischer, Maikel Wijtmans, Rob Leurs   +9 more
doaj   +1 more source

Structural Mechanism of an Efficacy Photoswitch Targeting the β2‐adrenergic Receptor

Angewandte Chemie International Edition, Volume 65, Issue 18, 27 April 2026.
Time‐resolved structures from x‐ray free‐electron laser measurements combined with cellular assays demonstrate how the photoswitchable β‐blocker photoazolol‐1 acts as an efficacy switch of β2‐adrenergic receptor function. Light‐induced ligand repositioning shifts activity from inverse agonism toward neutral antagonism by altering local helical ...
Robin Stipp, Quentin Bertrand, Matilde Trabuco, Anna Duran‐Corbera, Maria Tindara Ignazzitto, Hannah Glover, Fabienne Stierli, Juanlo Catena, Melissa Carrillo, Sina Hartmann, Hans‐Peter Seidel, Matthias Mulder, Thomas Mason, Yasushi Kondo, Maximillian Wranik, Martin Appleby, Christoph Sager, Raymond Sierra, Gregory Gate, Pamela Schleissner, Xinxin Cheng, Tobias Weinert, Robert Cheng, Sandra Mous, John H. Beale, Michal Kepa, Amadeu Llebaria, Michael Hennig, Xavier Rovira, Joerg Standfuss   +29 more
wiley   +1 more source