Results 61 to 70 of about 964 (143)

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Photopharmacology reveals high-specificity linkage of Ca2+ entry at TRPC6 nanodomains to NFAT activation in mast cells

Frontiers in Immunology
IntroductionPhotopharmacology has recently emerged as a strategy for high-precision modulation of immune functions. Here we explored efficiency and specificity of interventions based on light-induced TRPC6 activation in the RBL-2H3 mast cell model ...
Denis Krivić, Olga Panasiuk, Johannes Pilic, Roland Malli, Roland Malli, Bernadett Bacsa, Bernadett Bacsa, Sanja Ćurčić, Sanja Ćurčić, Klaus Groschner, Klaus Groschner   +10 more
doaj   +1 more source

Control of Brain State Transitions with a Photoswitchable Muscarinic Agonist

Advanced Science, 2021
The ability to control neural activity is essential for research not only in basic neuroscience, as spatiotemporal control of activity is a fundamental experimental tool, but also in clinical neurology for therapeutic brain interventions.
Almudena Barbero‐Castillo, Fabio Riefolo, Carlo Matera, Sara Caldas‐Martínez, Pedro Mateos‐Aparicio, Julia F. Weinert, Aida Garrido‐Charles, Enrique Claro, Maria V. Sanchez‐Vives, Pau Gorostiza   +9 more
doaj   +1 more source

Visible-Light Controlled Release of a Fluoroquinolone Antibiotic for Antimicrobial Photopharmacology

, 2018
Owing to the dwindling arsenal of antibiotics, new methodologies for their effective and localized delivery are necessary. The use of optical control over delivery of drugs, also known as photopharmacology, has emerged as an important option for the ...
Pooja Kumari (1507786), Harinath Chakrapani, Harinath Chakrapani (1743040), Amogh Kulkarni (4871599), Ajay Kumar Sharma (3174012), Amogh Kulkarni, Pooja Kumari, Ajay Kumar Sharma   +7 more
core   +1 more source

Control of Gemcitabine Activity With Blue and Red Light

Chemistry – A European Journal, Volume 32, Issue 38, 13 October 2026.
Treating cancer with chemotherapy is generally associated with many side effects, which can be addressed by selectively releasing the desired drugs with visible light. Sixteen new blue light‐activatable cytostatics were introduced, with the gemcitabine derivative exhibiting ideal properties.
Nils F. Kersten, Konstantin L. Stock, Marius Hyprath, Hannah Weisser, Timo Weinrich, Dieter Steinhilber, Alexander Heckel   +6 more
wiley   +1 more source

Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides

eLife, 2019
Ceramides are central intermediates of sphingolipid metabolism that also function as potent messengers in stress signaling and apoptosis. Progress in understanding how ceramides execute their biological roles is hampered by a lack of methods to ...
Matthijs Kol, Ben Williams, Henry Toombs-Ruane, Henri G Franquelim, Sergei Korneev, Christian Schroeer, Petra Schwille, Dirk Trauner, Joost CM Holthuis, James A Frank   +9 more
doaj   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, Volume 65, Issue 42, 12 October 2026.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Azobenzene's Cross‐Scale Optics and Photonics: Molecular Photoswitching, Mesoscopic Material Motions, and Adaptive Devices

Advanced Materials, Volume 38, Issue 56, 8 October 2026.
Azobenzene photoswitches translate molecular‐scale E/Z photoisomerization into macroscopic material responses and device‐level photonic functions. This Review highlights how azobenzene research has evolved from molecular photochemistry to photoalignment, mass migration, photomechanics, and heat release, ultimately enabling holography, reconfigurable ...
Heeju Son, Soyul Kwak, Heerin Noh, Minsang Kim, Doyeon Noh, Subhayan Chakraborty, Jaewon Lee, YongDeok Cho, Kyeongsoo Kim, Taewoong Eom, Moonyoung Kim, Jangwon Kim, Hoyoung Lee, Soyoung Lee, Jaehun Kim, Grace G. D. Han, Shin‐Tson Wu, Stefano Oscurato, Arri Priimagi, Marina Saphiannikova, Seungwoo Lee   +20 more
wiley   +1 more source

Phototherapy via Modulation of β‐Amyloid in Combating Alzheimer's Disease

Aggregate
Alzheimer's disease (AD) is one of the most prevalent forms of neurodegenerative disease. Although some controversy exists, β‐amyloid peptide (Aβ) is recognized to play an essential role in the pathophysiology of AD.
Yunhua Zhang, Chengyuan Qian, Yuncong Chen, Weijiang He, Zijian Guo   +4 more
doaj   +1 more source

Advancing Blue‐Light Photoactivatable TAM Kinase Inhibitors for Cancer Treatment: Challenges in Using π‐Extended Coumarins as Photocleavable Protecting Groups

ChemPhotoChem, Volume 10, Issue 10, October 2026.
Promise and obstacles of π‐extended coumarin as photolabile protecting groups for blue‐light photoactivatable TAM kinase inhibitors. We developed a series of photocleavable TAM kinase inhibitors that incorporate various π‐extended coumarins as photoremovable groups, enabling blue‐light activation.
Sébastien Billotte, Gaëlle Fontaine, Frédéric Bolze, Alexandre Specht, Sophie Bombard, Sandrine Piguel   +5 more
wiley   +1 more source