Results 71 to 80 of about 2,002 (201)
ChemistryEuropeWhile photopharmacology enables precise spatiotemporal control over drug activity, its widespread reliance on UV‐responsive molecules often hinders preclinical and clinical advancements. Thus, alternative scaffolds can offer promising advantages over the
Leticia M. Lazinski +6 more
doaj +1 more source
Control of Brain State Transitions with a Photoswitchable Muscarinic Agonist
Advanced Science, 2021 The ability to control neural activity is essential for research not only in basic neuroscience, as spatiotemporal control of activity is a fundamental experimental tool, but also in clinical neurology for therapeutic brain interventions.
Almudena Barbero‐Castillo +9 more
doaj +1 more source
Remote control of movement disorders using a photoactive adenosine A(2A) receptor antagonist [PDF]
, 2020 G protein-coupled adenosine receptors are promising therapeutic targets for a wide range of neuropathological conditions, including Parkinson's disease (PD).
Cabre, Gisela +8 more
core +1 more source
Reversible photocontrol of dopaminergic transmission in wild-type animals [PDF]
, 2022 Understanding the dopaminergic system is a priority in neurobiology and neuropharmacology. Dopamine receptors are involved in the modulation of fundamental physiological functions and dysregulation of dopaminergic transmission is associated with major ...
Calvé, Pablo +15 more
core +3 more sources
Optical Control of Glycerolipids and Sphingolipids
CHIMIA, 2021 Glycerolipids, Sphingolipids, and Sterols are the three major classes of membrane lipids. Both glycerolipids and sphingolipids are comprised of combinations of polar headgroups and fatty acid tails. The fatty acid tail can be chemically modified with an
Johannes Morstein, Dirk Trauner
doaj +1 more source
ChemPhotoChem, Volume 10, Issue 3, March 2026.Photoswitchable cyclic dipeptides (CDPs) can be used to prepare hydrogels that reversibly dissipate upon irradiation, or to photomodulate the development of living organisms. We report here applications and perspectives for CDPs containing azobenzene photoswitches or newly discovered hemipiperazine photoswitches in smart materials and biological ...
Zbigniew L. Pianowski
wiley +1 more source
Light‐Based Molecular Tools to Precisely Monitor and Operate β‐Adrenoceptors
Medicinal Research Reviews, Volume 46, Issue 2, Page 445-474, March 2026.ABSTRACT β‐Adrenoceptors are important G protein–coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light‐based molecular tools have been developed offering precise spatiotemporal control.
Ignazzitto Maria Tindara +3 more
wiley +1 more source
STAR Protocols, 2021 Summary: Small molecular probes designed for photopharmacology and opto-chemogenetics are rapidly gaining widespread recognition for investigations of transient receptor potential canonical (TRPC) channels.
Trese Leinders-Zufall +6 more
doaj +1 more source
Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides
eLife, 2019 Ceramides are central intermediates of sphingolipid metabolism that also function as potent messengers in stress signaling and apoptosis. Progress in understanding how ceramides execute their biological roles is hampered by a lack of methods to ...
Matthijs Kol +9 more
doaj +1 more source
Design of antibacterial molecules by photopharmacology (ECOPHOTOSKIN)
, 2023 Antibiotics are rejected in the environment after their use for treating human and animal bacterial infections. These residues are poorly eliminated by the actual wastewater treatment processes, impacting both animal, human and environmental health. This led to the emergence of antibiotic resistance in bacterial pathogens. To fight this issue, the last
Aubert, Amélie +4 more
openaire +2 more sources