Results 71 to 80 of about 964 (143)

A ‘double-edged’ role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs

eLife
We used light-sensitive drugs to identify the brain region-specific role of mGlu5 metabotropic glutamate receptors in the control of pain. Optical activation of systemic JF-NP-26, a caged, normally inactive, negative allosteric modulator (NAM) of mGlu5 ...
Serena Notartomaso, Nico Antenucci, Mariacristina Mazzitelli, Xavier Rovira, Serena Boccella, Flavia Ricciardi, Francesca Liberatore, Xavier Gomez-Santacana, Tiziana Imbriglio, Milena Cannella, Charleine Zussy, Livio Luongo, Sabatino Maione, Cyril Goudet, Giuseppe Battaglia, Amadeu Llebaria, Ferdinando Nicoletti, Volker Neugebauer   +17 more
doaj   +1 more source

Nanoengineered Light-Harvested Proteins for Optogenetics and Photopharmacology [PDF]

, 2019
Chemical modification with nanometer precision can be used to probe and to improve the function of complex molecular entities, from organic materials to proteins and their assemblies.
Gisela Cabré (8164768), Félix, Busqué, Aida Garrido-Charles (6089713), Marta, Gascón-Moya, Pau, Gorostiza, Jordi, Hernando, Aida, Garrido-Charles, Pau Gorostiza (6089642), Ramon, Alibés, Félix Busqué (8164827), Ramon Alibés (8164830), Marta Gascón-Moya (8164822), Gisela, Cabré, Jordi Hernando (8164762)   +13 more
core   +1 more source

Dosing PPARγ Activation With Light Using Fast Relaxing Photoswitches

Angewandte Chemie International Edition, Volume 65, Issue 40, 28 September 2026.
To achieve spatiotemporal control over PPARγ activity, we designed the fast‐relaxing photoswitchable agonist 6 that selectively activates PPARγ in its light‐induced Z‐state and relaxes within seconds (t1/2 47 s) to the inactive E‐state. This unique profile allowed light‐dosed receptor activation in in vitro settings, enabling biological studies on ...
Loris Knümann, Alba Rodriguez‐Paniagua, Martin Reynders, Silke Duensing‐Kropp, Oliver Thorn‐Seshold, Vasily Morozov, Julian A. Marschner, Daniel Merk   +7 more
wiley   +1 more source

Fully Reversible Regulation of 8‐17 DNAzyme Activity Using Nucleoside‐Based Diarylethenes

Chemistry – A European Journal, Volume 32, Issue 35, 19 September 2026.
The site‐specific incorporation of nucleosidic diarylethenes into the 8–17 deoxyribozyme (DNAzyme) identified position 2.1 as optimal. Compound dU‐PhtBu enabled efficient light‐dependent control of catalytic activity, while maintaining thermal stability and reversibility.
Jörn Bargstedt, Simon M. Büllmann, Sophia Conwell, Andres Jäschke   +3 more
wiley   +1 more source

Hemithioindigos for cellular tubulin photopharmacology: From proof of concept to near-quantitatively photoswitchable tools with single-cell precision [PDF]

, 2022
Microtubules (MTs) are hollow polymeric tubes formed of α/β-tubulin heterodimers that are in a constant dynamic equilibrium between growth and shrinkage. MTs are an essential constituent of the cytoskeleton and so are critical in many cellular processes,
Sailer, Alexander
core   +1 more source

Diarylethene‐Containing Photoswitchable Analogues of Tubulysins—Design, Synthesis, Biological, and Structural Evaluation

European Journal of Organic Chemistry, Volume 29, Issue 35, 19 September 2026.
Diarylethene‐containing cyclic tubulysin analogues were designed, synthesized, and evaluated as light‐responsive cytotoxic agents. One analogue showed reversible photoswitching, photoregulated tubulin polymerization inhibition, and photoform‐dependent cytotoxicity.
Anna Iampolska, Sergii Afonin, Oleg Babii, Mahri Park, Juan Estévez‐Gallego, Michel O. Steinmetz, Andrea E. Prota, Anne S. Ulrich, David R. Spring, Igor V. Komarov   +9 more
wiley   +1 more source

Remote control of wildtype zebrafish optomotor response with a photoswitchable drug

Frontiers in Behavioral Neuroscience
IntroductionFor animals to interact effectively with their environment, the brain must integrate sensory information and generate appropriate motor responses.
Luisa Camerin, Luisa Camerin, Luisa Camerin, Joaquín Martínez-Tambella, Joaquín Martínez-Tambella, Joaquín Martínez-Tambella, Gregor Schuhknecht, Vickie M. Wang, Vickie M. Wang, Kumaresh Krishnan, Paula Pflitsch, Florian Engert, Pau Gorostiza, Pau Gorostiza, Pau Gorostiza   +14 more
doaj   +1 more source

Phototherapy and photopharmacology.

The Yale journal of biology and medicine, 1986
The activation of 8-methoxypsoralen (8-MOP) by long-wavelength ultraviolet A light (UVA, 320-400 nm) induces the formation of interstrand cross-links in DNA. Psoralen plus UVA (PUVA) is widely used in the treatment of psoriasis, a hyperproliferative disease of the skin.
F P, Gasparro, G, Chan, R L, Edelson
openaire   +1 more source

Light‐Controlled Modulation of 15‐Lipoxygenase‐1 Regulates Intestinal Inflammatory Signaling

Angewandte Chemie, Volume 138, Issue 36, 1 September 2026.
The developed target‐guided strategy enables the rational design of diazo‐based photoswitchable inhibitors of 15‐lipoxygenase‐1. Distinct molecular architectures program opposite light‐dependent activity, allowing on‐demand control of enzyme inhibition.
Anastasia Louka, Eirini‐Eleni Kalaitzaki, Athanasios Panousis, Sotirios Bonoras, Charalampos Livas, George Froudakis, Ioannis Drygiannakis, Athina Damianaki, George Kolios, Vassilis Valatas, Nikolaos Eleftheriadis   +10 more
wiley   +1 more source

Probing the ionotropic activity of glutamate GluD2 receptor in HEK cells with genetically-engineered photopharmacology

eLife, 2020
Glutamate delta (GluD) receptors belong to the ionotropic glutamate receptor family, yet they don’t bind glutamate and are considered orphan. Progress in defining the ion channel function of GluDs in neurons has been hindered by a lack of pharmacological
Damien Lemoine, Sarah Mondoloni, Jérome Tange, Bertrand Lambolez, Philippe Faure, Antoine Taly, Ludovic Tricoire, Alexandre Mourot   +7 more
doaj   +1 more source