Results 91 to 100 of about 964 (143)

Photopharmacology

, 2014
Veel problemen die gerelateerd zijn aan geneesmiddelen, zoals bijwerkingen en resistentie, worden veroorzaakt doordat medicijnen altijd actief zijn: geneesmiddelen zijn actief in het hele lichaam waardoor bijwerkingen optreden en ze zijn zelfs nog actief in het milieu waardoor bacteriële resistentie kan ontstaan.
openaire   +1 more source

Nitric Oxide Photorelease from Silicone Films Doped with N-Nitroso BODIPY

Journal of Functional Biomaterials
Nitric oxide (NO) is a unique biochemical mediator involved in the regulation of vital processes. Light-controllable NO releasers show promise in the development of smart therapies.
Natalia A. Virts, Tatyana Yu. Karogodina, Mikhail A. Panfilov, Alexey Yu. Vorob’ev, Alexander E. Moskalensky   +4 more
doaj   +1 more source

Voltage-Gated ion channels: Structure, pharmacology and photopharmacology [PDF]

Voltage-gated ion channels are transmembrane proteins responsible for the generation and propagation of action potentials in excitable cells. Over the last decade, advancements have enabled the elucidation of crystal structures of ion channels.
Faraji, Shirin, Anguita-Ortiz, Nuria, Palmisano, Vito F., Faraji, Shirin; id_orcid, Nogueira, Juan Jose, Anguita Ortiz, Nuria, Nogueira Pérez, Juan José, Palmisano, Vito F   +7 more
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New magnetosensitive nanostructured materials: current status and research prospects

Хімія, фізика та технологія поверхні
The review analyzes and summarizes the results of research covering a wide range of topical issues in chemistry, physics, medicine (in particular oncology), photopharmacology, biology, and ecology. Examples of promising developments for practical use
P.P. Gorbyk, S.M. Makhno, O.M. Lisova, A.P. Kusyak, R.V. Mazurenko, S.L. Prokopenko, N.V. Kusyak, I.V. Dubrovin, S.P. Turanska, A.L. Petranovskaya, H.M. Hunia, O.M. Shcheglov   +11 more
doaj   +1 more source

A Quantum-Classical Method Applied to Material Design: Photochromic Materials Optimization for Photopharmacology Applications

The integration of quantum chemistry, machine learning, and optimization calculations is expected to accelerate materials discovery by making large chemical spaces amenable to computational study, a challenging task for classical computers. In this study,
Qi Gao, Takao Kobayashi, Paul D. Nation, Yu-ya Ohnishi, Michihiko Sugawara, Hiroyuki Tezuka, Naoki Yamamoto   +6 more
core   +1 more source

Recent Progress in Regulating the Activity of Enzymes with Photoswitchable Inhibitors

Molecules
Photoregulation of biomolecules has become crucial tools in chemical biology, because light enables access under mild conditions and with delicate spatiotemporal control. The control of enzyme activity in a reversible way is a challenge. To achieve it, a
Yi Chen
doaj   +1 more source

Towards medical imaging of drug photoactivation: Development of light responsive magnetic resonance imaging and chemical exchange saturation transfer contrast agents

Smart Molecules
In recent years, the use of light to selectively and precisely activate drugs has been developed along the fundamental concepts of photopharmacology.
Ilse M. Welleman, Carlijn L. F. vanBeek, Ioana Belcin, Albert M. Schulte, Rudi A. J. O. Dierckx, Ben L. Feringa, Hendrikus H. Boersma, Wiktor Szymański   +7 more
doaj   +1 more source

Synthesis and Characterization of a Bidirectional Photoswitchable Antagonist Toolbox for Real-Time GPCR Photopharmacology

, 2018
Noninvasive methods to modulate G protein-coupled receptors (GPCRs) with temporal and spatial precision are in great demand. Photopharmacology uses photons to control in situ the biological properties of photoswitchable small-molecule ligands, which ...
Wijtmans, Maikel, Smit, Martine J.; id_orcid, Albert J. Kooistra (726989), Vreeker, Gerda C.M., Rob Leurs (120648), Verweij, Eléonore W.E., Iwan J. P. de Esch, Lisa M. Wijnen (4962757), Lisa M. Wijnen, Maikel Wijtmans (1723222), Albert J. Kooistra, Albertus H. De Boer (4962754), Henry F. Vischer, Kooistra, Albert J., Hauwert, Niels J., Leurs, Rob, De Esch, Iwan J.P.; id_orcid, Albertus H. De Boer, Rob Leurs, Da Costa Pereira, Daniel, De Graaf, Chris, Niels J. Hauwert, Martine J. Smit (120656), Chris De Graaf (4962760), Maikel Wijtmans, Tamara A. M. Mocking, Eléonore W. E. Verweij, Gerda C. M. Vreeker (4962766), Tamara A. M. Mocking (4962763), Iwan J. P. de Esch (1289817), Wijnen, Lisa M., De Boer, Albertus H., Eléonore W. E. Verweij (4962772), Henry F. Vischer (726993), Mocking, Tamara A.M., Daniel Da Costa Pereira, Vischer, Henry F., Gerda C. M. Vreeker, Martine J. Smit, Chris De Graaf, Daniel Da Costa Pereira (4962769), Niels J. Hauwert (4962775)   +41 more
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Deuteration as a General Strategy to Enhance Azobenzene‐Based Photopharmacology

Angewandte Chemie International Edition
AbstractChemical photoswitches have become a widely used approach for the remote control of biological functions with spatiotemporal precision. Several molecular scaffolds have been implemented to improve photoswitch characteristics, ranging from the nature of the photoswitch itself (e.g. azobenzenes, dithienylethenes, hemithioindigo) to fine‐tuning of
Roßmann, Kilian, Gonzalez‐Hernandez, Alberto J., Bhuyan, Rahul, Schattenberg, Caspar, Sun, Han, Börjesson, Karl, Levitz, Joshua, Broichhagen, Johannes   +7 more
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Harnessing zebrafish as a model for photopharmacology:Insights into light-controlled biological effects of photoswitchable drugs

Photopharmacology is an emerging field of pharmacological sciences that enables precise spatiotemporal control over drug activation with light. In its reversible mode, it relies on photoswitchable bioactive compounds.
Bonan, Carla Denise, da Silva, Guilherme Pietro; id_orcid, Elsinga, Philip, da Silva, Rosane Souza, Szymanski, Wiktor, Doorduin, Janine; id_orcid   +5 more
core   +1 more source