Results 101 to 110 of about 964 (143)
The photopharmacology of nicotinic acetylcholine receptors
Neurotransmitter, 2016 Nicotinic acetylcholine receptors (nAChRs) are one of the most abundant classes of receptors present in the mammalian nervous system and play a significant role in synaptic transmission. The development of new tools that can precisely control the function of nAChRs is important for the study of their complex biological processes.
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Molecular Tools for Imaging and Photopharmacology
Light is a powerful, non-invasive tool that can be applied with precision in both space and time. As a result, it has been used in medical diagnostics and light-based therapies. Though light has a limited penetration depth in the body, it may prove useful for detecting or treating topical diseases, diseases in organs that can be reached with an ...
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Illuminating histamine receptor photopharmacology
, 2022 G Protein-coupled receptors (GPCRs) are transmembrane proteins that represent a highly important class of drug targets, being the primary target of about 35% of all marketed drugs. A prime family of GPCRs is the family of histamine receptors consisting of four distinct members named histamine H1 – H4 receptor (H1R-H4R). For further study of the role of
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The study is devoted to the development of the concept of targeted delivery of pharmacological agents. A nanocomposite (NC) – (LaF3:Tb/Citr@RuBiNic), which is formed by luminescent nanoparticles (ScNPs) – LaF3: Tb/Citr and a photosensitive substance ...
Yaroslav Shuba +5 more
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Photopharmacology of β-Adrenergic Receptors
G protein-coupled receptors (GPCRs) represent the largest family of membrane receptors in the human body and play central roles in numerous physiological systems. Consequently, GPCRs constitute one of the most important target classes in modern medicine and are targeted by approximately 36% of all approved therapeutic drugs.
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Harnessing zebrafish as a model for photopharmacology
Drug Discovery TodayPhotopharmacology is an emerging field of pharmacological sciences that enables precise spatiotemporal control over drug activation with light. In its reversible mode, it relies on photoswitchable bioactive compounds. The capacity to reversibly activate and deactivate drugs derivatized with photoswitches enables us to avoid side effects and ...
da Silva, Guilherme Pietro +5 more
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The adenosine A1 receptor (A1R) is a promising therapeutic target in epilepsy by mediating neuronal inhibition. In this study, we investigated whether A1R signaling is still functional in the intrahippocampal kainic acid (IHKA) mouse model for temporal ...
Boon, Paul +6 more
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Photopharmacology: Repurposing old GPCR targets with new smart drugs
G protein-coupled receptors (GPCR) are the largest family of membrane receptors targeted by commercial drugs. However, the proportion of approved small molecules targeting GPCRs has slowed down within the last years. In large part. this is due to adverse
Dumaze, Anaëlle +13 more
core
Precise photopharmacological eradication of metastatic tumor cells
Disease Models & MechanismsAdam Varady +8 more
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