Results 101 to 110 of about 2,002 (201)
Introduction to photoswitches and photopharmacology
Organic & Biomolecular ChemistryLight-control has become an essential element in biomedical research and chemical biology, since photons offer the possibility of precisely confining biological activity in space and time. Employing light-responsive molecules that undergo a structural change upon irradiation, researchers have been able to engineer pharmacophores whose bioactivity can ...
Cacciarini, Martina +3 more
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, 2023 Integration of quantum chemistry simulations, machine learning techniques, and optimization calculations is expected to accelerate material discovery by making large chemical spaces amenable to computational study; a challenging task for classical ...
Gao, Qi +6 more
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Study of the bactericidal effect of a light-transducing molecule on Escherichia coli [PDF]
, 2021 LAUREA MAGISTRALEIn questo lavoro ho studiato una molecola fotoattiva in grado di ripartirsi nella membrana lipidica dei batteri e di agire come un sistema antibatterico modulato dalla luce visibile.
Sora, Elia
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Azologization of serotonin 5-HT3 receptor antagonists
Beilstein Journal of Organic Chemistry, 2019 The serotonin 5-hydroxytryptamine 3 receptor (5-HT3R) plays a unique role within the seven classes of the serotonin receptor family, as it represents the only ionotropic receptor, while the other six members are G protein-coupled receptors (GPCRs). The 5-
Karin Rustler +3 more
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Nitric Oxide Photorelease from Silicone Films Doped with N-Nitroso BODIPY
Journal of Functional BiomaterialsNitric oxide (NO) is a unique biochemical mediator involved in the regulation of vital processes. Light-controllable NO releasers show promise in the development of smart therapies.
Natalia A. Virts +4 more
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Recent Progress in Regulating the Activity of Enzymes with Photoswitchable Inhibitors
MoleculesPhotoregulation of biomolecules has become crucial tools in chemical biology, because light enables access under mild conditions and with delicate spatiotemporal control. The control of enzyme activity in a reversible way is a challenge. To achieve it, a
Yi Chen
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Illuminating histamine receptor photopharmacology
, 2022 G Protein-coupled receptors (GPCRs) are transmembrane proteins that represent a highly important class of drug targets, being the primary target of about 35% of all marketed drugs. A prime family of GPCRs is the family of histamine receptors consisting of four distinct members named histamine H1 – H4 receptor (H1R-H4R). For further study of the role of
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Control of cortical slow oscillations and epileptiform discharges with photoswitchable type 1 muscarinic ligands [PDF]
Acetylcholine and the cholinergic system are crucial to brain function, including functions such as consciousness and cognition. Dysregulation of this system is implicated in the pathophysiology of neurological conditions such as Alzheimer's disease. For
Agnetta L. +11 more
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In vivo photopharmacology of adrenergic receptors
, 2021 Adrenoceptors are ubiquitous and regulate most vital functions in the human body, including heart and respiratory rate, digestion, smooth-muscle contraction, gland secretion, and pupil diameter among others. In addition, adrenergic neurons firing from the locus coeruleus towards different areas of the central nervous system mediate alertness, responses
D. Prischich +14 more
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