Results 81 to 90 of about 964 (143)
MoleculesPhotolabile protecting groups (PPGs), also known as caging groups, are valuable tools in photopharmacology. They enable precise control over the release of bioactive compounds from the corresponding caged compounds at a precisely controlled time and ...
Marta López-Corrales, Vicente Marchán
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Potent hemithioindigo-based antimitotics photocontrol the microtubule cytoskeleton in cellulo
Beilstein Journal of Organic Chemistry, 2020 Background: Hemithioindigo is a promising molecular photoswitch that has only recently been applied as a photoswitchable pharmacophore for control over bioactivity in cellulo. Uniquely, in contrast to other photoswitches that have been applied to biology,
Alexander Sailer +6 more
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Controlling Biological Pathways with Photopharmacology [PDF]
Biophysical Journal, 2016 Light can be used to control biological events with unmatched temporal and spatial precision. A case in point is optogenetics, which relies on natural photoreceptors that employ retinal, flavins or tetrapyrrols as chromophores. Recently, the incorporation of synthetic photoswitches, such as azobenzenes, into naturally “blind” native receptors has been ...
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Photopharmacological Cholinergic Modulation of Cortical Activity in Human Brain Slices
Brain SciencesBackground/Objectives: Understanding the unique properties of human neurons is crucial for advancing knowledge of brain function and facilitating clinical translation.
Jose Manuel Sanchez-Sanchez +9 more
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Azologization of serotonin 5-HT3 receptor antagonists
Beilstein Journal of Organic Chemistry, 2019 The serotonin 5-hydroxytryptamine 3 receptor (5-HT3R) plays a unique role within the seven classes of the serotonin receptor family, as it represents the only ionotropic receptor, while the other six members are G protein-coupled receptors (GPCRs). The 5-
Karin Rustler +3 more
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Optical Control of Adenosine A3 Receptor Signaling: Towards a Multimodal Phototherapy in Psoriasis?
Frontiers in Immunology, 2022 Francisco Ciruela +2 more
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FEBS Open BioIntracellular Ca2+ regulates insulin secretion from pancreatic β‐cells and is influenced by cannabinoid signaling. However, the hydrophobicity and complex pharmacology of cannabinoid ligands prevent precision receptor targeting, limiting our ...
Alexander E. G. Viray, James A. Frank
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MoleculesChalcones have garnered significant research interest due to their various medical bioactivities. Several chalcone compounds have been approved for marketing and clinical use in the treatment of various diseases.
Piotr Tobiasz +5 more
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Neuropsychopharmacology ReportsAim Photopharmacology is a new technique for modulating biological phenomena through the photoconversion of substances in a specific target region at precise times.
Shogo Okada +7 more
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