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Specificity and Speed: Tethered Photopharmacology
Biochemistry, 2017Genetics and pharmacology are often seen as two distinct approaches to interrogating, elucidating, and manipulating biological systems. The former is renowned for its precision whereas the latter for its fast kinetics, reversibility, and practicality.
Philipp Leippe +2 more
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Photopharmacology in Alzheimer's Disease
Advanced Therapeutics, 2018AbstractIn this report, the advances of photopharmacology as a method that allows the study of therapeutically relevant target proteins for Alzheimer's disease (AD) with high spatiotemporal resolution through photoswitchable molecules that are manipulated by light irradiation will be presented.
Diego Alejandro Rodríguez‐Soacha +1 more
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Optofluidic neural interfaces for in vivo photopharmacology
Current Opinion in Pharmacology, 2022Light-sensitive small molecules can be applied to control cell signaling with enhanced spatiotemporal precision, and their accuracy in intact tissues like the brain can be further enhanced by tethering them to genetically encoded protein tags. Coined "photopharmacology," this approach can acutely manipulate neurotransmission through specific receptor ...
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Triplet-Triplet Annihilation Upconversion-Based Photolysis: Applications in Photopharmacology
Advanced Healthcare MaterialsInternational audienceThe emerging field of photopharmacology is a promising chemobiological methodology for optical control of drug activities that could ultimately solve the off-target toxicity outside the disease location of many drugs for the ...
Alexandre Specht +2 more
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New challenges for photopharmacology and computational modeling
Trends in Biochemical Sciences, 2022Mous et al. recently reported the molecular mechanism of chloride transport through a light-activated pumping rhodopsin, a key process involved in a range of cellular functions. Their results open exciting new challenges for photopharmacology and computational modeling that should be addressed in the coming years.
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Recent Progress in Azobenzene-Based in Vivo Photopharmacology
Medicinal Research ReviewsABSTRACTAs the most extensively studied photoswitch in photopharmacology, the azobenzene photoswitch has precision instrumental in the photoregulation of physiological processes across various animal models. Currently, it exhibits the greatest clinical potential for photosensitive retinal restoration, capable of inducing long‐term therapeutic effects ...
Lupei Du, Minyong Li
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Reprogramming pain signaling through photopharmacology
Trends in Pharmacological SciencesPain remains a major clinical challenge because current analgesics lack spatiotemporal precision and frequently induce systemic adverse effects, tolerance, and dependence. Recent advances in photopharmacology have enabled reversible optical control of ion channels, G protein-coupled receptors, and neural circuits involved in nociceptive processing ...
Xinyi Fang +5 more
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Photopharmacology and Photochemical Biology
ChemPhotoChem, 2021Alexander Deiters +2 more
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Implantable Optofluidic Systems for Wireless in Vivo Photopharmacology
ChemPhotoChem, 2021Jae-Woong Jeong +2 more
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